Superparamagnetic iron oxide nanoparticles in biomedicine: applications and developments in diagnostics and therapy
Standard
Superparamagnetic iron oxide nanoparticles in biomedicine: applications and developments in diagnostics and therapy. / Ittrich, H; Peldschus, K; Raabe, N; Kaul, M; Adam, G.
in: ROFO-FORTSCHR RONTG, Jahrgang 185, Nr. 12, 01.12.2013, S. 1149-66.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Superparamagnetic iron oxide nanoparticles in biomedicine: applications and developments in diagnostics and therapy
AU - Ittrich, H
AU - Peldschus, K
AU - Raabe, N
AU - Kaul, M
AU - Adam, G
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based µNMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy.
AB - Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based µNMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy.
KW - Animals
KW - Coated Materials, Biocompatible
KW - Ferrosoferric Oxide
KW - Humans
KW - Lymphatic Metastasis
KW - Magnetic Resonance Angiography
KW - Magnetic Resonance Imaging
KW - Magnetic Resonance Spectroscopy
KW - Metabolic Clearance Rate
KW - Molecular Imaging
KW - Molecular Targeted Therapy
KW - Nanoparticles
KW - Neoplasms
KW - Particle Size
KW - Quality Control
KW - Sensitivity and Specificity
U2 - 10.1055/s-0033-1335438
DO - 10.1055/s-0033-1335438
M3 - SCORING: Journal article
C2 - 24008761
VL - 185
SP - 1149
EP - 1166
JO - ROFO-FORTSCHR RONTG
JF - ROFO-FORTSCHR RONTG
SN - 1438-9029
IS - 12
ER -