PortalPublikationenSuccessful treatment of Pseudomonas aeruginosa respiratory t...

Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution--a case report on a lectin based therapeutic principle

Standard

Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution--a case report on a lectin based therapeutic principle. / von Bismarck, P; Schneppenheim, R; Schumacher, U.

in: KLIN PADIATR, Jahrgang 213, Nr. 5, 03.10.2001, S. 285-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

von Bismarck, P, Schneppenheim, R & Schumacher, U 2001, 'Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution--a case report on a lectin based therapeutic principle', KLIN PADIATR, Jg. 213, Nr. 5, S. 285-7. https://doi.org/10.1055/s-2001-17220

APA

von Bismarck, P., Schneppenheim, R., & Schumacher, U. (2001). Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution--a case report on a lectin based therapeutic principle. KLIN PADIATR, 213(5), 285-7. https://doi.org/10.1055/s-2001-17220

Vancouver

von Bismarck P, Schneppenheim R, Schumacher U. Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution--a case report on a lectin based therapeutic principle. KLIN PADIATR. 2001 Okt 3;213(5):285-7. https://doi.org/10.1055/s-2001-17220

Bibtex

@article{996c2c8b19cc42cf98eddefeb82a6493,
title = "Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution--a case report on a lectin based therapeutic principle",
abstract = "BACKGROUND: Airway infections with Pseudomonas aeruginosa often represent a life-threatening event in immuno-compromised patients or patients with Cystic Fibrosis. The adhesion of this bacterium to surfaces such as the airway epithelium is mediated by two lectins, sugar binding proteins. In addition to their adhesive properties, these lectins have been shown to stop human ciliary beating thus compromising the mucociliary clearance as an important non-specific defence mechanism of the airways. Inhibition of these lectins by their specific sugars galactose and fucose, respectively, could therefore be of benefit in the elimination therapy of P. aeruginosa.CASE REPORT: An infant suffering from P. aeruginosa airway infection after chemotherapy for neuroblastoma, which could not successfully be treated by antibiotics, was subjected to a series of additional galactose/fucose inhalations, which eliminated the germ as evidenced by microbiological testing. This is the first report suggesting the effectiveness of a lectin-based therapeutic principle in P. aeruginosa airway infection.CONCLUSION: The competitive inhibition of P. aeruginosa lectins by the lectin specific sugars galactose and fucose may overcome particular mechanisms of bacterial resistance in patients with P. aeruginosa airway infection. This underlying biochemical mechanism and the outcome of our patient suggest a clinical benefit of this novel therapeutic approach for immunocompromised patients or patients with cystic fibrosis suffering from infection with P. aeruginosa.",
keywords = "Abdominal Neoplasms, Anti-Bacterial Agents, Bacterial Proteins, Drug Resistance, Microbial, Fucose, Galactose, Humans, Infant, Lectins, Male, Neuroblastoma, Postoperative Complications, Pseudomonas Infections, Pseudomonas aeruginosa, Respiratory Therapy, Respiratory Tract Infections",
author = "{von Bismarck}, P and R Schneppenheim and U Schumacher",
year = "2001",
month = oct,
day = "3",
doi = "10.1055/s-2001-17220",
language = "English",
volume = "213",
pages = "285--7",
journal = "KLIN PADIATR",
issn = "0300-8630",
publisher = "Georg Thieme Verlag KG",
number = "5",

}

RIS

TY - JOUR

T1 - Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution--a case report on a lectin based therapeutic principle

AU - von Bismarck, P

AU - Schneppenheim, R

AU - Schumacher, U

PY - 2001/10/3

Y1 - 2001/10/3

N2 - BACKGROUND: Airway infections with Pseudomonas aeruginosa often represent a life-threatening event in immuno-compromised patients or patients with Cystic Fibrosis. The adhesion of this bacterium to surfaces such as the airway epithelium is mediated by two lectins, sugar binding proteins. In addition to their adhesive properties, these lectins have been shown to stop human ciliary beating thus compromising the mucociliary clearance as an important non-specific defence mechanism of the airways. Inhibition of these lectins by their specific sugars galactose and fucose, respectively, could therefore be of benefit in the elimination therapy of P. aeruginosa.CASE REPORT: An infant suffering from P. aeruginosa airway infection after chemotherapy for neuroblastoma, which could not successfully be treated by antibiotics, was subjected to a series of additional galactose/fucose inhalations, which eliminated the germ as evidenced by microbiological testing. This is the first report suggesting the effectiveness of a lectin-based therapeutic principle in P. aeruginosa airway infection.CONCLUSION: The competitive inhibition of P. aeruginosa lectins by the lectin specific sugars galactose and fucose may overcome particular mechanisms of bacterial resistance in patients with P. aeruginosa airway infection. This underlying biochemical mechanism and the outcome of our patient suggest a clinical benefit of this novel therapeutic approach for immunocompromised patients or patients with cystic fibrosis suffering from infection with P. aeruginosa.

AB - BACKGROUND: Airway infections with Pseudomonas aeruginosa often represent a life-threatening event in immuno-compromised patients or patients with Cystic Fibrosis. The adhesion of this bacterium to surfaces such as the airway epithelium is mediated by two lectins, sugar binding proteins. In addition to their adhesive properties, these lectins have been shown to stop human ciliary beating thus compromising the mucociliary clearance as an important non-specific defence mechanism of the airways. Inhibition of these lectins by their specific sugars galactose and fucose, respectively, could therefore be of benefit in the elimination therapy of P. aeruginosa.CASE REPORT: An infant suffering from P. aeruginosa airway infection after chemotherapy for neuroblastoma, which could not successfully be treated by antibiotics, was subjected to a series of additional galactose/fucose inhalations, which eliminated the germ as evidenced by microbiological testing. This is the first report suggesting the effectiveness of a lectin-based therapeutic principle in P. aeruginosa airway infection.CONCLUSION: The competitive inhibition of P. aeruginosa lectins by the lectin specific sugars galactose and fucose may overcome particular mechanisms of bacterial resistance in patients with P. aeruginosa airway infection. This underlying biochemical mechanism and the outcome of our patient suggest a clinical benefit of this novel therapeutic approach for immunocompromised patients or patients with cystic fibrosis suffering from infection with P. aeruginosa.

KW - Abdominal Neoplasms

KW - Anti-Bacterial Agents

KW - Bacterial Proteins

KW - Drug Resistance, Microbial

KW - Fucose

KW - Galactose

KW - Humans

KW - Infant

KW - Lectins

KW - Male

KW - Neuroblastoma

KW - Postoperative Complications

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

KW - Respiratory Therapy

KW - Respiratory Tract Infections

U2 - 10.1055/s-2001-17220

DO - 10.1055/s-2001-17220

M3 - SCORING: Journal article

C2 - 11582527

VL - 213

SP - 285

EP - 287

JO - KLIN PADIATR

JF - KLIN PADIATR

SN - 0300-8630

IS - 5

ER -