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Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study

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Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study. / Kalbe, Elke; Rehberg, Sarah Petra; Heber, Ines; Kronenbuerger, Martin; Schulz, Jörg B; Storch, Alexander; Linse, Katharina; Schneider, Christine; Gräber, Susanne; Liepelt-Scarfone, Inga; Berg, Daniela; Dams, Judith; Balzer-Geldsetzer, Monika; Hilker, Rüdiger; Oberschmidt, Carola; Witt, Karsten; Schmidt, Nele; Mollenhauer, Brit; Trenkwalder, Claudia; Spottke, Annika; Roeske, Sandra; Wittchen, Hans-Ulrich; Riedel, Oliver; Dodel, Richard.

in: J NEUROL NEUROSUR PS, Jahrgang 87, Nr. 10, 10.2016, S. 1099-1105.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kalbe, E, Rehberg, SP, Heber, I, Kronenbuerger, M, Schulz, JB, Storch, A, Linse, K, Schneider, C, Gräber, S, Liepelt-Scarfone, I, Berg, D, Dams, J, Balzer-Geldsetzer, M, Hilker, R, Oberschmidt, C, Witt, K, Schmidt, N, Mollenhauer, B, Trenkwalder, C, Spottke, A, Roeske, S, Wittchen, H-U, Riedel, O & Dodel, R 2016, 'Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study', J NEUROL NEUROSUR PS, Jg. 87, Nr. 10, S. 1099-1105. https://doi.org/10.1136/jnnp-2016-313838

APA

Kalbe, E., Rehberg, S. P., Heber, I., Kronenbuerger, M., Schulz, J. B., Storch, A., Linse, K., Schneider, C., Gräber, S., Liepelt-Scarfone, I., Berg, D., Dams, J., Balzer-Geldsetzer, M., Hilker, R., Oberschmidt, C., Witt, K., Schmidt, N., Mollenhauer, B., Trenkwalder, C., ... Dodel, R. (2016). Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study. J NEUROL NEUROSUR PS, 87(10), 1099-1105. https://doi.org/10.1136/jnnp-2016-313838

Vancouver

Kalbe E, Rehberg SP, Heber I, Kronenbuerger M, Schulz JB, Storch A et al. Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study. J NEUROL NEUROSUR PS. 2016 Okt;87(10):1099-1105. https://doi.org/10.1136/jnnp-2016-313838

Bibtex

@article{39dfe6a505134b72862a7ad912d7162c,
title = "Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study",
abstract = "OBJECTIVE: Inconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI.METHODS: Sociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed.RESULTS: 269 patients with PD-MCI (age 67.8±7.4, Unified Parkinson's Disease Rating Scale (UPDRS-III) scores 23.2±11.6) were included. PD-MCI subtypes were 39.4% non-amnestic single domain, 30.5% amnestic multiple domain, 23.4% non-amnestic multiple domain and 6.7% amnestic single domain. Executive functions were most frequently impaired. The most sensitive tests to detect cognitive dysfunctions were the Modified Card Sorting Test, digit span backwards and word list learning direct recall. Multiple stepwise regression analyses showed that global cognition, gender and age, but not education or disease-related parameters predicted PD-MCI subtypes.CONCLUSIONS: This study with the so far largest number of prospectively recruited patients with PD-MCI indicates that non-amnestic PD-MCI is more frequent than amnestic PD-MCI; executive dysfunctions are the most typical cognitive symptom in PD-MCI; and age, gender and global cognition predict the PD-MCI subtype. Longitudinal data are needed to test the hypothesis that patients with PD-MCI with specific cognitive profiles have different risks to develop dementia.",
keywords = "Journal Article",
author = "Elke Kalbe and Rehberg, {Sarah Petra} and Ines Heber and Martin Kronenbuerger and Schulz, {J{\"o}rg B} and Alexander Storch and Katharina Linse and Christine Schneider and Susanne Gr{\"a}ber and Inga Liepelt-Scarfone and Daniela Berg and Judith Dams and Monika Balzer-Geldsetzer and R{\"u}diger Hilker and Carola Oberschmidt and Karsten Witt and Nele Schmidt and Brit Mollenhauer and Claudia Trenkwalder and Annika Spottke and Sandra Roeske and Hans-Ulrich Wittchen and Oliver Riedel and Richard Dodel",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/",
year = "2016",
month = oct,
doi = "10.1136/jnnp-2016-313838",
language = "English",
volume = "87",
pages = "1099--1105",
journal = "J NEUROL NEUROSUR PS",
issn = "0022-3050",
publisher = "BMJ PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study

AU - Kalbe, Elke

AU - Rehberg, Sarah Petra

AU - Heber, Ines

AU - Kronenbuerger, Martin

AU - Schulz, Jörg B

AU - Storch, Alexander

AU - Linse, Katharina

AU - Schneider, Christine

AU - Gräber, Susanne

AU - Liepelt-Scarfone, Inga

AU - Berg, Daniela

AU - Dams, Judith

AU - Balzer-Geldsetzer, Monika

AU - Hilker, Rüdiger

AU - Oberschmidt, Carola

AU - Witt, Karsten

AU - Schmidt, Nele

AU - Mollenhauer, Brit

AU - Trenkwalder, Claudia

AU - Spottke, Annika

AU - Roeske, Sandra

AU - Wittchen, Hans-Ulrich

AU - Riedel, Oliver

AU - Dodel, Richard

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PY - 2016/10

Y1 - 2016/10

N2 - OBJECTIVE: Inconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI.METHODS: Sociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed.RESULTS: 269 patients with PD-MCI (age 67.8±7.4, Unified Parkinson's Disease Rating Scale (UPDRS-III) scores 23.2±11.6) were included. PD-MCI subtypes were 39.4% non-amnestic single domain, 30.5% amnestic multiple domain, 23.4% non-amnestic multiple domain and 6.7% amnestic single domain. Executive functions were most frequently impaired. The most sensitive tests to detect cognitive dysfunctions were the Modified Card Sorting Test, digit span backwards and word list learning direct recall. Multiple stepwise regression analyses showed that global cognition, gender and age, but not education or disease-related parameters predicted PD-MCI subtypes.CONCLUSIONS: This study with the so far largest number of prospectively recruited patients with PD-MCI indicates that non-amnestic PD-MCI is more frequent than amnestic PD-MCI; executive dysfunctions are the most typical cognitive symptom in PD-MCI; and age, gender and global cognition predict the PD-MCI subtype. Longitudinal data are needed to test the hypothesis that patients with PD-MCI with specific cognitive profiles have different risks to develop dementia.

AB - OBJECTIVE: Inconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI.METHODS: Sociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed.RESULTS: 269 patients with PD-MCI (age 67.8±7.4, Unified Parkinson's Disease Rating Scale (UPDRS-III) scores 23.2±11.6) were included. PD-MCI subtypes were 39.4% non-amnestic single domain, 30.5% amnestic multiple domain, 23.4% non-amnestic multiple domain and 6.7% amnestic single domain. Executive functions were most frequently impaired. The most sensitive tests to detect cognitive dysfunctions were the Modified Card Sorting Test, digit span backwards and word list learning direct recall. Multiple stepwise regression analyses showed that global cognition, gender and age, but not education or disease-related parameters predicted PD-MCI subtypes.CONCLUSIONS: This study with the so far largest number of prospectively recruited patients with PD-MCI indicates that non-amnestic PD-MCI is more frequent than amnestic PD-MCI; executive dysfunctions are the most typical cognitive symptom in PD-MCI; and age, gender and global cognition predict the PD-MCI subtype. Longitudinal data are needed to test the hypothesis that patients with PD-MCI with specific cognitive profiles have different risks to develop dementia.

KW - Journal Article

U2 - 10.1136/jnnp-2016-313838

DO - 10.1136/jnnp-2016-313838

M3 - SCORING: Journal article

C2 - 27401782

VL - 87

SP - 1099

EP - 1105

JO - J NEUROL NEUROSUR PS

JF - J NEUROL NEUROSUR PS

SN - 0022-3050

IS - 10

ER -