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Subthalamic deep brain stimulation increases pallidal firing rate and regularity

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Subthalamic deep brain stimulation increases pallidal firing rate and regularity. / Reese, René; Leblois, Arthur; Steigerwald, Frank; Pötter-Nerger, Monika; Herzog, Jan; Mehdorn, H Maximilian; Deuschl, Günther; Meissner, Wassilios G; Volkmann, Jens.

in: EXP NEUROL, Jahrgang 229, Nr. 2, 06.2011, S. 517-21.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Reese, R, Leblois, A, Steigerwald, F, Pötter-Nerger, M, Herzog, J, Mehdorn, HM, Deuschl, G, Meissner, WG & Volkmann, J 2011, 'Subthalamic deep brain stimulation increases pallidal firing rate and regularity', EXP NEUROL, Jg. 229, Nr. 2, S. 517-21. https://doi.org/10.1016/j.expneurol.2011.01.020

APA

Reese, R., Leblois, A., Steigerwald, F., Pötter-Nerger, M., Herzog, J., Mehdorn, H. M., Deuschl, G., Meissner, W. G., & Volkmann, J. (2011). Subthalamic deep brain stimulation increases pallidal firing rate and regularity. EXP NEUROL, 229(2), 517-21. https://doi.org/10.1016/j.expneurol.2011.01.020

Vancouver

Reese R, Leblois A, Steigerwald F, Pötter-Nerger M, Herzog J, Mehdorn HM et al. Subthalamic deep brain stimulation increases pallidal firing rate and regularity. EXP NEUROL. 2011 Jun;229(2):517-21. https://doi.org/10.1016/j.expneurol.2011.01.020

Bibtex

@article{9b85d803d6374d46aafe57113ed95ed9,
title = "Subthalamic deep brain stimulation increases pallidal firing rate and regularity",
abstract = "While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.",
keywords = "Action Potentials, Deep Brain Stimulation, Electrodes, Implanted, Globus Pallidus, Humans, Neurons, Parkinson Disease, Subthalamic Nucleus, Journal Article, Research Support, Non-U.S. Gov't",
author = "Ren{\'e} Reese and Arthur Leblois and Frank Steigerwald and Monika P{\"o}tter-Nerger and Jan Herzog and Mehdorn, {H Maximilian} and G{\"u}nther Deuschl and Meissner, {Wassilios G} and Jens Volkmann",
note = "Copyright {\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2011",
month = jun,
doi = "10.1016/j.expneurol.2011.01.020",
language = "English",
volume = "229",
pages = "517--21",
journal = "EXP NEUROL",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Subthalamic deep brain stimulation increases pallidal firing rate and regularity

AU - Reese, René

AU - Leblois, Arthur

AU - Steigerwald, Frank

AU - Pötter-Nerger, Monika

AU - Herzog, Jan

AU - Mehdorn, H Maximilian

AU - Deuschl, Günther

AU - Meissner, Wassilios G

AU - Volkmann, Jens

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/6

Y1 - 2011/6

N2 - While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.

AB - While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.

KW - Action Potentials

KW - Deep Brain Stimulation

KW - Electrodes, Implanted

KW - Globus Pallidus

KW - Humans

KW - Neurons

KW - Parkinson Disease

KW - Subthalamic Nucleus

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.expneurol.2011.01.020

DO - 10.1016/j.expneurol.2011.01.020

M3 - SCORING: Journal article

C2 - 21303674

VL - 229

SP - 517

EP - 521

JO - EXP NEUROL

JF - EXP NEUROL

SN - 0014-4886

IS - 2

ER -