Subcortical, modality-specific pathways contribute to multisensory processing in humans
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Subcortical, modality-specific pathways contribute to multisensory processing in humans. / van den Brink, R L; Cohen, M X; van der Burg, E; Talsma, D; Vissers, M E; Slagter, H A.
in: CEREB CORTEX, Jahrgang 24, Nr. 8, 08.2014, S. 2169-77.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Subcortical, modality-specific pathways contribute to multisensory processing in humans
AU - van den Brink, R L
AU - Cohen, M X
AU - van der Burg, E
AU - Talsma, D
AU - Vissers, M E
AU - Slagter, H A
N1 - © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PY - 2014/8
Y1 - 2014/8
N2 - Oftentimes, we perceive our environment by integrating information across multiple senses. Recent studies suggest that such integration occurs at much earlier processing stages than once thought possible, including in thalamic nuclei and putatively unisensory cortical brain regions. Here, we used diffusion tensor imaging (DTI) and an audiovisual integration task to test the hypothesis that anatomical connections between sensory-related subcortical structures and sensory cortical areas govern multisensory processing in humans. Twenty-five subjects (mean age 22 years, 22 females) participated in the study. In line with our hypothesis, we show that estimated strength of white-matter connections between the first relay station in the auditory processing stream (the cochlear nucleus), the auditory thalamus, and primary auditory cortex predicted one's ability to combine auditory and visual information in a visual search task. This finding supports a growing body of work that indicates that subcortical sensory pathways do not only feed forward unisensory information to the cortex, and suggests that anatomical brain connectivity contributes to multisensory processing ability in humans.
AB - Oftentimes, we perceive our environment by integrating information across multiple senses. Recent studies suggest that such integration occurs at much earlier processing stages than once thought possible, including in thalamic nuclei and putatively unisensory cortical brain regions. Here, we used diffusion tensor imaging (DTI) and an audiovisual integration task to test the hypothesis that anatomical connections between sensory-related subcortical structures and sensory cortical areas govern multisensory processing in humans. Twenty-five subjects (mean age 22 years, 22 females) participated in the study. In line with our hypothesis, we show that estimated strength of white-matter connections between the first relay station in the auditory processing stream (the cochlear nucleus), the auditory thalamus, and primary auditory cortex predicted one's ability to combine auditory and visual information in a visual search task. This finding supports a growing body of work that indicates that subcortical sensory pathways do not only feed forward unisensory information to the cortex, and suggests that anatomical brain connectivity contributes to multisensory processing ability in humans.
KW - Acoustic Stimulation
KW - Auditory Perception
KW - Brain
KW - Diffusion Tensor Imaging
KW - Electrooculography
KW - Eye Movements
KW - Female
KW - Humans
KW - Male
KW - Neural Pathways
KW - Neuropsychological Tests
KW - Photic Stimulation
KW - Visual Perception
KW - White Matter
KW - Young Adult
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1093/cercor/bht069
DO - 10.1093/cercor/bht069
M3 - SCORING: Journal article
C2 - 23529004
VL - 24
SP - 2169
EP - 2177
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 8
ER -
