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Study of physical function in adolescents with haemophilia: The SO-FIT study

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Study of physical function in adolescents with haemophilia: The SO-FIT study. / Khair, K; Holland, M; Bladen, M; Griffioen, A; McLaughlin, P; von Mackensen, S; SO-FIT Study Group.

in: HAEMOPHILIA, Jahrgang 23, Nr. 6, 11.2017, S. 918-925.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Khair, K, Holland, M, Bladen, M, Griffioen, A, McLaughlin, P, von Mackensen, S & SO-FIT Study Group 2017, 'Study of physical function in adolescents with haemophilia: The SO-FIT study', HAEMOPHILIA, Jg. 23, Nr. 6, S. 918-925. https://doi.org/10.1111/hae.13323

APA

Khair, K., Holland, M., Bladen, M., Griffioen, A., McLaughlin, P., von Mackensen, S., & SO-FIT Study Group (2017). Study of physical function in adolescents with haemophilia: The SO-FIT study. HAEMOPHILIA, 23(6), 918-925. https://doi.org/10.1111/hae.13323

Vancouver

Khair K, Holland M, Bladen M, Griffioen A, McLaughlin P, von Mackensen S et al. Study of physical function in adolescents with haemophilia: The SO-FIT study. HAEMOPHILIA. 2017 Nov;23(6):918-925. https://doi.org/10.1111/hae.13323

Bibtex

@article{88f9dc27110a4336bb158f306824bb98,
title = "Study of physical function in adolescents with haemophilia: The SO-FIT study",
abstract = "INTRODUCTION: Contemporary haemophilia care demands Patient-Reported Outcomes. SO-FIT is a UK multi-centre study, assessing self-reported function, health-related quality of life (HRQoL) and joint health in boys with severe haemophilia.METHODS: Subjective physical function (PedHAL, HEP-Test-Q) and HRQoL (Haemo-QoL Short Form [SF]) were assessed alongside joint health using the objective Haemophilia Joint Health Score (HJHS v2.1). Demographic and clinical data were collected.RESULTS: Data from 127 boys mean age 12.38 ± 2.5 (range 8-17) treated at 16 sites were analysed. One-hundred-and-thirteen had haemophilia A, 25/9 past/current inhibitor, 124 were treated prophylactically (46.8% primary) and three on-demand. In the preceding 6 months, boys reported median 0 joint bleeds (range 0-8) with a median HJHS score of 1 (range 0-30). Boys reported good physical functioning; HEP-Test-Q (M = 80.32 ± 16.1) showed the highest impairments in the domain {"}endurance{"} (72.53 ± 19.1), in PedHAL (M = 85.44 ± 18.9) highest impairments were in the domains {"}leisure activities & sports{"} (M = 82.43 ± 23.4) and {"}lying/sitting/kneeling/standing{"} (M = 83.22 ± 20.3). Boys reported generally good HRQoL in Haemo-QoL SF SF (M = 22.81 ± 15.0) with highest impairments in the domains {"}friends{"} (M = 28.81 ± 30.5) and {"}sports & school{"} (M = 26.14 ± 25.1). HJHS revealed low correlations with the Haemo-QoL SF (r = .251, P < .006), the PedHAL (r = -.397, P < .0001) and the HEP-Test-Q (r = -.323, P < .0001). A moderate correlation was seen between HEP-Test-Q and Haemo-QoL SF of r = -.575 (P < .0001) and between PedHAL and Haemo-QoL SFr = -.561 (P < .0001) implying that good perceived physical function is related to good HRQoL.CONCLUSIONS: The SO-FIT study has demonstrated that children with severe haemophilia in the UK report good HRQoL and have good joint health as reflected in low HJHS scores.",
keywords = "Journal Article",
author = "K Khair and M Holland and M Bladen and A Griffioen and P McLaughlin and {von Mackensen}, S and {SO-FIT Study Group}",
note = "{\textcopyright} 2017 John Wiley & Sons Ltd.",
year = "2017",
month = nov,
doi = "10.1111/hae.13323",
language = "English",
volume = "23",
pages = "918--925",
journal = "HAEMOPHILIA",
issn = "1351-8216",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Study of physical function in adolescents with haemophilia: The SO-FIT study

AU - Khair, K

AU - Holland, M

AU - Bladen, M

AU - Griffioen, A

AU - McLaughlin, P

AU - von Mackensen, S

AU - SO-FIT Study Group

N1 - © 2017 John Wiley & Sons Ltd.

PY - 2017/11

Y1 - 2017/11

N2 - INTRODUCTION: Contemporary haemophilia care demands Patient-Reported Outcomes. SO-FIT is a UK multi-centre study, assessing self-reported function, health-related quality of life (HRQoL) and joint health in boys with severe haemophilia.METHODS: Subjective physical function (PedHAL, HEP-Test-Q) and HRQoL (Haemo-QoL Short Form [SF]) were assessed alongside joint health using the objective Haemophilia Joint Health Score (HJHS v2.1). Demographic and clinical data were collected.RESULTS: Data from 127 boys mean age 12.38 ± 2.5 (range 8-17) treated at 16 sites were analysed. One-hundred-and-thirteen had haemophilia A, 25/9 past/current inhibitor, 124 were treated prophylactically (46.8% primary) and three on-demand. In the preceding 6 months, boys reported median 0 joint bleeds (range 0-8) with a median HJHS score of 1 (range 0-30). Boys reported good physical functioning; HEP-Test-Q (M = 80.32 ± 16.1) showed the highest impairments in the domain "endurance" (72.53 ± 19.1), in PedHAL (M = 85.44 ± 18.9) highest impairments were in the domains "leisure activities & sports" (M = 82.43 ± 23.4) and "lying/sitting/kneeling/standing" (M = 83.22 ± 20.3). Boys reported generally good HRQoL in Haemo-QoL SF SF (M = 22.81 ± 15.0) with highest impairments in the domains "friends" (M = 28.81 ± 30.5) and "sports & school" (M = 26.14 ± 25.1). HJHS revealed low correlations with the Haemo-QoL SF (r = .251, P < .006), the PedHAL (r = -.397, P < .0001) and the HEP-Test-Q (r = -.323, P < .0001). A moderate correlation was seen between HEP-Test-Q and Haemo-QoL SF of r = -.575 (P < .0001) and between PedHAL and Haemo-QoL SFr = -.561 (P < .0001) implying that good perceived physical function is related to good HRQoL.CONCLUSIONS: The SO-FIT study has demonstrated that children with severe haemophilia in the UK report good HRQoL and have good joint health as reflected in low HJHS scores.

AB - INTRODUCTION: Contemporary haemophilia care demands Patient-Reported Outcomes. SO-FIT is a UK multi-centre study, assessing self-reported function, health-related quality of life (HRQoL) and joint health in boys with severe haemophilia.METHODS: Subjective physical function (PedHAL, HEP-Test-Q) and HRQoL (Haemo-QoL Short Form [SF]) were assessed alongside joint health using the objective Haemophilia Joint Health Score (HJHS v2.1). Demographic and clinical data were collected.RESULTS: Data from 127 boys mean age 12.38 ± 2.5 (range 8-17) treated at 16 sites were analysed. One-hundred-and-thirteen had haemophilia A, 25/9 past/current inhibitor, 124 were treated prophylactically (46.8% primary) and three on-demand. In the preceding 6 months, boys reported median 0 joint bleeds (range 0-8) with a median HJHS score of 1 (range 0-30). Boys reported good physical functioning; HEP-Test-Q (M = 80.32 ± 16.1) showed the highest impairments in the domain "endurance" (72.53 ± 19.1), in PedHAL (M = 85.44 ± 18.9) highest impairments were in the domains "leisure activities & sports" (M = 82.43 ± 23.4) and "lying/sitting/kneeling/standing" (M = 83.22 ± 20.3). Boys reported generally good HRQoL in Haemo-QoL SF SF (M = 22.81 ± 15.0) with highest impairments in the domains "friends" (M = 28.81 ± 30.5) and "sports & school" (M = 26.14 ± 25.1). HJHS revealed low correlations with the Haemo-QoL SF (r = .251, P < .006), the PedHAL (r = -.397, P < .0001) and the HEP-Test-Q (r = -.323, P < .0001). A moderate correlation was seen between HEP-Test-Q and Haemo-QoL SF of r = -.575 (P < .0001) and between PedHAL and Haemo-QoL SFr = -.561 (P < .0001) implying that good perceived physical function is related to good HRQoL.CONCLUSIONS: The SO-FIT study has demonstrated that children with severe haemophilia in the UK report good HRQoL and have good joint health as reflected in low HJHS scores.

KW - Journal Article

U2 - 10.1111/hae.13323

DO - 10.1111/hae.13323

M3 - SCORING: Journal article

C2 - 28806864

VL - 23

SP - 918

EP - 925

JO - HAEMOPHILIA

JF - HAEMOPHILIA

SN - 1351-8216

IS - 6

ER -