Structural brain imaging: a window into chronic pain.
Standard
Structural brain imaging: a window into chronic pain. / May, Arne.
in: NEUROSCIENTIST, Jahrgang 17, Nr. 2, 2, 2011, S. 209-220.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Structural brain imaging: a window into chronic pain.
AU - May, Arne
PY - 2011
Y1 - 2011
N2 - Structural imaging is turning our attention regarding the effects of chronic pain on the brain as a possible source of chronicity. Several independent studies have suggested a decrease in gray matter in pain-transmitting areas in patients with constant pain. Most of these data are discussed as representing damage or loss of brain gray matter, reinforcing the idea of chronic pain as a progressive disease. However, any data of an increase or decrease in gray matter in pain syndromes need to be considered in light of all observations gathered in the past 10 years and probably do not justify a discussion of brain damage or consideration of whether the disease is progressive. It is likely that these changes are the consequence and not the cause of the respective pain syndromes as they may reverse once the pain is adequately treated. Moreover, structural changes of the brain may not be specific to a particular pain syndrome and for the moment only mirror the magnitude or duration of pain suffered. The topographical distributions of gray matter changes may well be the consequence of cortical regions having varying susceptibilities. We need to better understand the behavioral consequences and cellular mechanisms underlying these neuroanatomic changes.
AB - Structural imaging is turning our attention regarding the effects of chronic pain on the brain as a possible source of chronicity. Several independent studies have suggested a decrease in gray matter in pain-transmitting areas in patients with constant pain. Most of these data are discussed as representing damage or loss of brain gray matter, reinforcing the idea of chronic pain as a progressive disease. However, any data of an increase or decrease in gray matter in pain syndromes need to be considered in light of all observations gathered in the past 10 years and probably do not justify a discussion of brain damage or consideration of whether the disease is progressive. It is likely that these changes are the consequence and not the cause of the respective pain syndromes as they may reverse once the pain is adequately treated. Moreover, structural changes of the brain may not be specific to a particular pain syndrome and for the moment only mirror the magnitude or duration of pain suffered. The topographical distributions of gray matter changes may well be the consequence of cortical regions having varying susceptibilities. We need to better understand the behavioral consequences and cellular mechanisms underlying these neuroanatomic changes.
KW - Animals
KW - Humans
KW - Chronic Disease
KW - Brain/pathology
KW - Brain Mapping
KW - Diagnostic Imaging/methods
KW - Neural Pathways/pathology
KW - Pain/classification/complications/pathology
KW - Animals
KW - Humans
KW - Chronic Disease
KW - Brain/pathology
KW - Brain Mapping
KW - Diagnostic Imaging/methods
KW - Neural Pathways/pathology
KW - Pain/classification/complications/pathology
M3 - SCORING: Journal article
VL - 17
SP - 209
EP - 220
JO - NEUROSCIENTIST
JF - NEUROSCIENTIST
SN - 1073-8584
IS - 2
M1 - 2
ER -