Stress and disease progression in multiple sclerosis and its animal models.
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Stress and disease progression in multiple sclerosis and its animal models. / Gold, Stefan M; Heesen, Christoph.
in: NEUROIMMUNOMODULAT, Jahrgang 13, Nr. 5-6, 5-6, 2006, S. 318-326.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Stress and disease progression in multiple sclerosis and its animal models.
AU - Gold, Stefan M
AU - Heesen, Christoph
PY - 2006
Y1 - 2006
N2 - Since the first description of multiple sclerosis (MS) by Charcot, stress has been hypothesized to be a potential trigger of relapses. In recent years, data from observational studies in MS patients have provided some support for an association between stress and MS relapses. Furthermore, studies employing the MS animal model experimental autoimmune encephalomyelitis have shown that certain stressors can exacerbate the disease if administered prior to disease induction. Several lines of research have explored the 2 major stress response systems--the hypothalamic-pituitary-adrenal axis and the autonomic nervous system--and their relation to disease course in MS and experimental autoimmune encephalomyelitis. These studies provide evidence that insensitivity of the immune system to signals from these systems may play a role in inflammatory events. These findings can be integrated into a biological model of stress response system alterations in MS.
AB - Since the first description of multiple sclerosis (MS) by Charcot, stress has been hypothesized to be a potential trigger of relapses. In recent years, data from observational studies in MS patients have provided some support for an association between stress and MS relapses. Furthermore, studies employing the MS animal model experimental autoimmune encephalomyelitis have shown that certain stressors can exacerbate the disease if administered prior to disease induction. Several lines of research have explored the 2 major stress response systems--the hypothalamic-pituitary-adrenal axis and the autonomic nervous system--and their relation to disease course in MS and experimental autoimmune encephalomyelitis. These studies provide evidence that insensitivity of the immune system to signals from these systems may play a role in inflammatory events. These findings can be integrated into a biological model of stress response system alterations in MS.
M3 - SCORING: Zeitschriftenaufsatz
VL - 13
SP - 318
EP - 326
JO - NEUROIMMUNOMODULAT
JF - NEUROIMMUNOMODULAT
SN - 1021-7401
IS - 5-6
M1 - 5-6
ER -
