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Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

Standard

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. / Hoffmann, Linda S; Etzrodt, Jennifer; Willkomm, Lena; Sanyal, Abhishek; Scheja, Ludger; Fischer, Alexander W C; Stasch, Johannes-Peter; Bloch, Wilhelm; Friebe, Andreas; Heeren, Joerg; Pfeifer, Alexander.

in: NAT COMMUN, Jahrgang 6, 05.2015, S. Art. 7235.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hoffmann, LS, Etzrodt, J, Willkomm, L, Sanyal, A, Scheja, L, Fischer, AWC, Stasch, J-P, Bloch, W, Friebe, A, Heeren, J & Pfeifer, A 2015, 'Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue', NAT COMMUN, Jg. 6, S. Art. 7235. https://doi.org/10.1038/ncomms8235

APA

Hoffmann, L. S., Etzrodt, J., Willkomm, L., Sanyal, A., Scheja, L., Fischer, A. W. C., Stasch, J-P., Bloch, W., Friebe, A., Heeren, J., & Pfeifer, A. (2015). Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. NAT COMMUN, 6, Art. 7235. https://doi.org/10.1038/ncomms8235

Vancouver

Hoffmann LS, Etzrodt J, Willkomm L, Sanyal A, Scheja L, Fischer AWC et al. Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. NAT COMMUN. 2015 Mai;6:Art. 7235. https://doi.org/10.1038/ncomms8235

Bibtex

@article{aa3ca5ba227346568e1036d3af7b3555,
title = "Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue",
abstract = "Obesity is characterized by a positive energy balance and expansion of white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) combusts energy to produce heat. Here we show that a small molecule stimulator (BAY 41-8543) of soluble guanylyl cyclase (sGC), which produces the second messenger cyclic GMP (cGMP), protects against diet-induced weight gain, induces weight loss in established obesity, and also improves the diabetic phenotype. Mechanistically, the haeme-dependent sGC stimulator BAY 41-8543 enhances lipid uptake into BAT and increases whole-body energy expenditure, whereas ablation of the haeme-containing β1-subunit of sGC severely impairs BAT function. Notably, the sGC stimulator enhances differentiation of human brown adipocytes as well as induces 'browning' of primary white adipocytes. Taken together, our data suggest that sGC is a potential pharmacological target for the treatment of obesity and its comorbidities.",
author = "Hoffmann, {Linda S} and Jennifer Etzrodt and Lena Willkomm and Abhishek Sanyal and Ludger Scheja and Fischer, {Alexander W C} and Johannes-Peter Stasch and Wilhelm Bloch and Andreas Friebe and Joerg Heeren and Alexander Pfeifer",
year = "2015",
month = may,
doi = "10.1038/ncomms8235",
language = "English",
volume = "6",
pages = "Art. 7235",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

AU - Hoffmann, Linda S

AU - Etzrodt, Jennifer

AU - Willkomm, Lena

AU - Sanyal, Abhishek

AU - Scheja, Ludger

AU - Fischer, Alexander W C

AU - Stasch, Johannes-Peter

AU - Bloch, Wilhelm

AU - Friebe, Andreas

AU - Heeren, Joerg

AU - Pfeifer, Alexander

PY - 2015/5

Y1 - 2015/5

N2 - Obesity is characterized by a positive energy balance and expansion of white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) combusts energy to produce heat. Here we show that a small molecule stimulator (BAY 41-8543) of soluble guanylyl cyclase (sGC), which produces the second messenger cyclic GMP (cGMP), protects against diet-induced weight gain, induces weight loss in established obesity, and also improves the diabetic phenotype. Mechanistically, the haeme-dependent sGC stimulator BAY 41-8543 enhances lipid uptake into BAT and increases whole-body energy expenditure, whereas ablation of the haeme-containing β1-subunit of sGC severely impairs BAT function. Notably, the sGC stimulator enhances differentiation of human brown adipocytes as well as induces 'browning' of primary white adipocytes. Taken together, our data suggest that sGC is a potential pharmacological target for the treatment of obesity and its comorbidities.

AB - Obesity is characterized by a positive energy balance and expansion of white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) combusts energy to produce heat. Here we show that a small molecule stimulator (BAY 41-8543) of soluble guanylyl cyclase (sGC), which produces the second messenger cyclic GMP (cGMP), protects against diet-induced weight gain, induces weight loss in established obesity, and also improves the diabetic phenotype. Mechanistically, the haeme-dependent sGC stimulator BAY 41-8543 enhances lipid uptake into BAT and increases whole-body energy expenditure, whereas ablation of the haeme-containing β1-subunit of sGC severely impairs BAT function. Notably, the sGC stimulator enhances differentiation of human brown adipocytes as well as induces 'browning' of primary white adipocytes. Taken together, our data suggest that sGC is a potential pharmacological target for the treatment of obesity and its comorbidities.

U2 - 10.1038/ncomms8235

DO - 10.1038/ncomms8235

M3 - SCORING: Journal article

C2 - 26011238

VL - 6

SP - Art. 7235

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -