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Steroid regulation of T cell function appears unaltered in borderline personality disorder

Standard

Steroid regulation of T cell function appears unaltered in borderline personality disorder. / Fischer, Anja; Grundmann, Johanna; Gold, Stefan M; Spitzer, Carsten; Wingenfeld, Katja.

in: J PERS DISORD, Jahrgang 29, Nr. 2, 04.2015, S. 241-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fischer, A, Grundmann, J, Gold, SM, Spitzer, C & Wingenfeld, K 2015, 'Steroid regulation of T cell function appears unaltered in borderline personality disorder', J PERS DISORD, Jg. 29, Nr. 2, S. 241-7. https://doi.org/10.1521/pedi_2014_28_156

APA

Fischer, A., Grundmann, J., Gold, S. M., Spitzer, C., & Wingenfeld, K. (2015). Steroid regulation of T cell function appears unaltered in borderline personality disorder. J PERS DISORD, 29(2), 241-7. https://doi.org/10.1521/pedi_2014_28_156

Vancouver

Fischer A, Grundmann J, Gold SM, Spitzer C, Wingenfeld K. Steroid regulation of T cell function appears unaltered in borderline personality disorder. J PERS DISORD. 2015 Apr;29(2):241-7. https://doi.org/10.1521/pedi_2014_28_156

Bibtex

@article{903aca4865254a019f43dd537bf6b4aa,
title = "Steroid regulation of T cell function appears unaltered in borderline personality disorder",
abstract = "Borderline personality disorder (BPD) is characterized by instability of interpersonal relationships and affection, impulsivity, and cognitive disruptions. Increasing evidence suggests hypothalamic-pituitary-adrenal (HPA) axis alterations in BPD. Changed glucocorticoid sensitivity of peripheral blood mononuclear cells is known in mood and posttraumatic stress disorders, representing frequent comorbidities in BPD. However, to the authors' knowledge, in BPD glucocorticoid sensitivity at the receptor level remains unexplored. Sixteen age-matched female BPD patients were compared to sixteen female healthy controls. In vitro steroid sensitivity of T cell proliferation was tested using aldosterone, dexamethasone, and hydrocortisone. Steroid sensitivity of BPD patients and healthy controls appeared comparable. Psychiatric comorbidities such as major depressive disorder or posttraumatic stress disorder and early life stress seemed to have had no influence on steroid sensitivity parameters. The data suggest unaltered GC sensitivity of T cell function in BPD.",
keywords = "Adult, Aldosterone, Borderline Personality Disorder, Case-Control Studies, Dexamethasone, Female, Glucocorticoids, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Leukocytes, Mononuclear, Middle Aged, Pituitary-Adrenal System, T-Lymphocytes",
author = "Anja Fischer and Johanna Grundmann and Gold, {Stefan M} and Carsten Spitzer and Katja Wingenfeld",
year = "2015",
month = apr,
doi = "10.1521/pedi_2014_28_156",
language = "English",
volume = "29",
pages = "241--7",
journal = "J PERS DISORD",
issn = "0885-579X",
publisher = "Guilford Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Steroid regulation of T cell function appears unaltered in borderline personality disorder

AU - Fischer, Anja

AU - Grundmann, Johanna

AU - Gold, Stefan M

AU - Spitzer, Carsten

AU - Wingenfeld, Katja

PY - 2015/4

Y1 - 2015/4

N2 - Borderline personality disorder (BPD) is characterized by instability of interpersonal relationships and affection, impulsivity, and cognitive disruptions. Increasing evidence suggests hypothalamic-pituitary-adrenal (HPA) axis alterations in BPD. Changed glucocorticoid sensitivity of peripheral blood mononuclear cells is known in mood and posttraumatic stress disorders, representing frequent comorbidities in BPD. However, to the authors' knowledge, in BPD glucocorticoid sensitivity at the receptor level remains unexplored. Sixteen age-matched female BPD patients were compared to sixteen female healthy controls. In vitro steroid sensitivity of T cell proliferation was tested using aldosterone, dexamethasone, and hydrocortisone. Steroid sensitivity of BPD patients and healthy controls appeared comparable. Psychiatric comorbidities such as major depressive disorder or posttraumatic stress disorder and early life stress seemed to have had no influence on steroid sensitivity parameters. The data suggest unaltered GC sensitivity of T cell function in BPD.

AB - Borderline personality disorder (BPD) is characterized by instability of interpersonal relationships and affection, impulsivity, and cognitive disruptions. Increasing evidence suggests hypothalamic-pituitary-adrenal (HPA) axis alterations in BPD. Changed glucocorticoid sensitivity of peripheral blood mononuclear cells is known in mood and posttraumatic stress disorders, representing frequent comorbidities in BPD. However, to the authors' knowledge, in BPD glucocorticoid sensitivity at the receptor level remains unexplored. Sixteen age-matched female BPD patients were compared to sixteen female healthy controls. In vitro steroid sensitivity of T cell proliferation was tested using aldosterone, dexamethasone, and hydrocortisone. Steroid sensitivity of BPD patients and healthy controls appeared comparable. Psychiatric comorbidities such as major depressive disorder or posttraumatic stress disorder and early life stress seemed to have had no influence on steroid sensitivity parameters. The data suggest unaltered GC sensitivity of T cell function in BPD.

KW - Adult

KW - Aldosterone

KW - Borderline Personality Disorder

KW - Case-Control Studies

KW - Dexamethasone

KW - Female

KW - Glucocorticoids

KW - Humans

KW - Hydrocortisone

KW - Hypothalamo-Hypophyseal System

KW - Leukocytes, Mononuclear

KW - Middle Aged

KW - Pituitary-Adrenal System

KW - T-Lymphocytes

U2 - 10.1521/pedi_2014_28_156

DO - 10.1521/pedi_2014_28_156

M3 - SCORING: Journal article

C2 - 25248018

VL - 29

SP - 241

EP - 247

JO - J PERS DISORD

JF - J PERS DISORD

SN - 0885-579X

IS - 2

ER -