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Steps toward mapping the human vasculature by phage display

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Steps toward mapping the human vasculature by phage display. / Arap, Wadih; Kolonin, Mikhail G; Trepel, Martin; Lahdenranta, Johanna; Cardó-Vila, Marina; Giordano, Ricardo J; Mintz, Paul J; Ardelt, Peter U; Yao, Virginia J; Vidal, Claudia I; Chen, Limor; Flamm, Anne L; Valtanen, Heli; Weavind, Lisa M; Hicks, Marshall E; Pollock, Raphael E; Botz, Gregory H; Bucana, Corazon D; Koivunen, Erkki; Cahill, Dolores J; Troncoso, Patricia; Baggerly, Keith A; Pentz, Rebecca D; Do, Kim-Anh; Logothetis, Christopher J; Pasqualini, Renata.

in: NAT MED, Jahrgang 8, Nr. 2, 02.2002, S. 121-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Arap, W, Kolonin, MG, Trepel, M, Lahdenranta, J, Cardó-Vila, M, Giordano, RJ, Mintz, PJ, Ardelt, PU, Yao, VJ, Vidal, CI, Chen, L, Flamm, AL, Valtanen, H, Weavind, LM, Hicks, ME, Pollock, RE, Botz, GH, Bucana, CD, Koivunen, E, Cahill, DJ, Troncoso, P, Baggerly, KA, Pentz, RD, Do, K-A, Logothetis, CJ & Pasqualini, R 2002, 'Steps toward mapping the human vasculature by phage display', NAT MED, Jg. 8, Nr. 2, S. 121-7. https://doi.org/10.1038/nm0202-121

APA

Arap, W., Kolonin, M. G., Trepel, M., Lahdenranta, J., Cardó-Vila, M., Giordano, R. J., Mintz, P. J., Ardelt, P. U., Yao, V. J., Vidal, C. I., Chen, L., Flamm, A. L., Valtanen, H., Weavind, L. M., Hicks, M. E., Pollock, R. E., Botz, G. H., Bucana, C. D., Koivunen, E., ... Pasqualini, R. (2002). Steps toward mapping the human vasculature by phage display. NAT MED, 8(2), 121-7. https://doi.org/10.1038/nm0202-121

Vancouver

Arap W, Kolonin MG, Trepel M, Lahdenranta J, Cardó-Vila M, Giordano RJ et al. Steps toward mapping the human vasculature by phage display. NAT MED. 2002 Feb;8(2):121-7. https://doi.org/10.1038/nm0202-121

Bibtex

@article{8bef52f237414451b04407f5826bb9b3,
title = "Steps toward mapping the human vasculature by phage display",
abstract = "The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the first in vivo screening of a peptide library in a patient. We surveyed 47,160 motifs that localized to different organs. This large-scale screening indicates that the tissue distribution of circulating peptides is nonrandom. High-throughput analysis of the motifs revealed similarities to ligands for differentially expressed cell-surface proteins, and a candidate ligand-receptor pair was validated. These data represent a step toward the construction of a molecular map of human vasculature and may have broad implications for the development of targeted therapies.",
keywords = "Blood Vessels, Genetic Variation, Humans, Oligopeptides, Organ Specificity, Peptide Library, Reproducibility of Results, Software, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.",
author = "Wadih Arap and Kolonin, {Mikhail G} and Martin Trepel and Johanna Lahdenranta and Marina Card{\'o}-Vila and Giordano, {Ricardo J} and Mintz, {Paul J} and Ardelt, {Peter U} and Yao, {Virginia J} and Vidal, {Claudia I} and Limor Chen and Flamm, {Anne L} and Heli Valtanen and Weavind, {Lisa M} and Hicks, {Marshall E} and Pollock, {Raphael E} and Botz, {Gregory H} and Bucana, {Corazon D} and Erkki Koivunen and Cahill, {Dolores J} and Patricia Troncoso and Baggerly, {Keith A} and Pentz, {Rebecca D} and Kim-Anh Do and Logothetis, {Christopher J} and Renata Pasqualini",
year = "2002",
month = feb,
doi = "10.1038/nm0202-121",
language = "English",
volume = "8",
pages = "121--7",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Steps toward mapping the human vasculature by phage display

AU - Arap, Wadih

AU - Kolonin, Mikhail G

AU - Trepel, Martin

AU - Lahdenranta, Johanna

AU - Cardó-Vila, Marina

AU - Giordano, Ricardo J

AU - Mintz, Paul J

AU - Ardelt, Peter U

AU - Yao, Virginia J

AU - Vidal, Claudia I

AU - Chen, Limor

AU - Flamm, Anne L

AU - Valtanen, Heli

AU - Weavind, Lisa M

AU - Hicks, Marshall E

AU - Pollock, Raphael E

AU - Botz, Gregory H

AU - Bucana, Corazon D

AU - Koivunen, Erkki

AU - Cahill, Dolores J

AU - Troncoso, Patricia

AU - Baggerly, Keith A

AU - Pentz, Rebecca D

AU - Do, Kim-Anh

AU - Logothetis, Christopher J

AU - Pasqualini, Renata

PY - 2002/2

Y1 - 2002/2

N2 - The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the first in vivo screening of a peptide library in a patient. We surveyed 47,160 motifs that localized to different organs. This large-scale screening indicates that the tissue distribution of circulating peptides is nonrandom. High-throughput analysis of the motifs revealed similarities to ligands for differentially expressed cell-surface proteins, and a candidate ligand-receptor pair was validated. These data represent a step toward the construction of a molecular map of human vasculature and may have broad implications for the development of targeted therapies.

AB - The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the first in vivo screening of a peptide library in a patient. We surveyed 47,160 motifs that localized to different organs. This large-scale screening indicates that the tissue distribution of circulating peptides is nonrandom. High-throughput analysis of the motifs revealed similarities to ligands for differentially expressed cell-surface proteins, and a candidate ligand-receptor pair was validated. These data represent a step toward the construction of a molecular map of human vasculature and may have broad implications for the development of targeted therapies.

KW - Blood Vessels

KW - Genetic Variation

KW - Humans

KW - Oligopeptides

KW - Organ Specificity

KW - Peptide Library

KW - Reproducibility of Results

KW - Software

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

U2 - 10.1038/nm0202-121

DO - 10.1038/nm0202-121

M3 - SCORING: Journal article

C2 - 11821895

VL - 8

SP - 121

EP - 127

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 2

ER -