Startle stimuli exert opposite effects on human cortical and spinal motor system excitability in leg muscles

T V Ilic; M Pötter-Nerger; I Holler; H R Siebner; N V Ilic; G Deuschl; J Volkmann

Startle stimuli exert opposite effects on human cortical and spinal motor system excitability in leg muscles

Standard

Startle stimuli exert opposite effects on human cortical and spinal motor system excitability in leg muscles. / Ilic, T V; Pötter-Nerger, M; Holler, I; Siebner, H R; Ilic, N V; Deuschl, G; Volkmann, J.

in: PHYSIOL RES, Jahrgang 60 Suppl 1, 2011, S. S101-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ilic, TV, Pötter-Nerger, M, Holler, I, Siebner, HR, Ilic, NV, Deuschl, G & Volkmann, J 2011, 'Startle stimuli exert opposite effects on human cortical and spinal motor system excitability in leg muscles', PHYSIOL RES, Jg. 60 Suppl 1, S. S101-6.

APA

Ilic, T. V., Pötter-Nerger, M., Holler, I., Siebner, H. R., Ilic, N. V., Deuschl, G., & Volkmann, J. (2011). Startle stimuli exert opposite effects on human cortical and spinal motor system excitability in leg muscles. PHYSIOL RES, 60 Suppl 1, S101-6.

Vancouver

Ilic TV, Pötter-Nerger M, Holler I, Siebner HR, Ilic NV, Deuschl G et al. Startle stimuli exert opposite effects on human cortical and spinal motor system excitability in leg muscles. PHYSIOL RES. 2011;60 Suppl 1:S101-6.

Bibtex

@article{d3dcc2521cae4f1da8cabbd6adcffd5b,

title = "Startle stimuli exert opposite effects on human cortical and spinal motor system excitability in leg muscles",

abstract = "Increased excitability of the spinal motor system has been observed after loud and unexpected acoustic stimuli (AS) preceding H-reflexes. The paradigm has been proposed as an electrophysiological marker of reticulospinal tract activity in humans. The brainstem reticular formation also maintains dense anatomical interconnections with the cortical motor system. When a startling AS is delivered, prior to transcranial magnetic stimulation (TMS), the AS produces a suppression of motor evoked potential (MEP) amplitude in hand and arm muscles of healthy subjects. Here we analyzed the conditioning effect of a startling AS on MEP amplitude evoked by TMS to the primary motor leg area. Ten healthy volunteers participated in two experiments that used a conditioning-test paradigm. In the first experiment, a startling AS preceded a suprathreshold transcranial test stimulus. The interstimulus interval (ISI) varied between 20 to 160 ms. When given alone, the test stimulus evoked a MEP amplitude of approximately 0.5 mV in the slightly preinervated soleus muscle (SOL). In the second experiment, the startling AS was used to condition the size of the H-reflex in SOL muscle. Mean MEP amplitude was calculated for each ISI. The conditioning AS suppressed MEP amplitude at ISIs of 30-80 ms. By contrast, H-reflex amplitude was augmented at ISIs of 100-200 ms. In conclusions, acoustic stimulation exerts opposite and ISI-specific effects on the amplitude of MEPs and H-reflex in the SOL muscle, indicating different mechanism of auditory-to-motor interactions at cortical and spinal level of motor system.",

keywords = "Acoustic Stimulation, Adult, Analysis of Variance, Cerebral Cortex, Electromyography, Evoked Potentials, Motor, Female, Germany, H-Reflex, Humans, Lower Extremity, Male, Motor Neurons, Muscle, Skeletal, Neural Inhibition, Reflex, Startle, Spinal Nerves, Time Factors, Transcranial Magnetic Stimulation, Journal Article, Randomized Controlled Trial",

author = "Ilic, {T V} and M P{\"o}tter-Nerger and I Holler and Siebner, {H R} and Ilic, {N V} and G Deuschl and J Volkmann",

year = "2011",

language = "English",

volume = "60 Suppl 1",

pages = "S101--6",

journal = "PHYSIOL RES",

issn = "0862-8408",

publisher = "Czech Academy of Sciences",

}

RIS

TY - JOUR

T1 - Startle stimuli exert opposite effects on human cortical and spinal motor system excitability in leg muscles

AU - Ilic, T V

AU - Pötter-Nerger, M

AU - Holler, I

AU - Siebner, H R

AU - Ilic, N V

AU - Deuschl, G

AU - Volkmann, J

PY - 2011

Y1 - 2011

N2 - Increased excitability of the spinal motor system has been observed after loud and unexpected acoustic stimuli (AS) preceding H-reflexes. The paradigm has been proposed as an electrophysiological marker of reticulospinal tract activity in humans. The brainstem reticular formation also maintains dense anatomical interconnections with the cortical motor system. When a startling AS is delivered, prior to transcranial magnetic stimulation (TMS), the AS produces a suppression of motor evoked potential (MEP) amplitude in hand and arm muscles of healthy subjects. Here we analyzed the conditioning effect of a startling AS on MEP amplitude evoked by TMS to the primary motor leg area. Ten healthy volunteers participated in two experiments that used a conditioning-test paradigm. In the first experiment, a startling AS preceded a suprathreshold transcranial test stimulus. The interstimulus interval (ISI) varied between 20 to 160 ms. When given alone, the test stimulus evoked a MEP amplitude of approximately 0.5 mV in the slightly preinervated soleus muscle (SOL). In the second experiment, the startling AS was used to condition the size of the H-reflex in SOL muscle. Mean MEP amplitude was calculated for each ISI. The conditioning AS suppressed MEP amplitude at ISIs of 30-80 ms. By contrast, H-reflex amplitude was augmented at ISIs of 100-200 ms. In conclusions, acoustic stimulation exerts opposite and ISI-specific effects on the amplitude of MEPs and H-reflex in the SOL muscle, indicating different mechanism of auditory-to-motor interactions at cortical and spinal level of motor system.

AB - Increased excitability of the spinal motor system has been observed after loud and unexpected acoustic stimuli (AS) preceding H-reflexes. The paradigm has been proposed as an electrophysiological marker of reticulospinal tract activity in humans. The brainstem reticular formation also maintains dense anatomical interconnections with the cortical motor system. When a startling AS is delivered, prior to transcranial magnetic stimulation (TMS), the AS produces a suppression of motor evoked potential (MEP) amplitude in hand and arm muscles of healthy subjects. Here we analyzed the conditioning effect of a startling AS on MEP amplitude evoked by TMS to the primary motor leg area. Ten healthy volunteers participated in two experiments that used a conditioning-test paradigm. In the first experiment, a startling AS preceded a suprathreshold transcranial test stimulus. The interstimulus interval (ISI) varied between 20 to 160 ms. When given alone, the test stimulus evoked a MEP amplitude of approximately 0.5 mV in the slightly preinervated soleus muscle (SOL). In the second experiment, the startling AS was used to condition the size of the H-reflex in SOL muscle. Mean MEP amplitude was calculated for each ISI. The conditioning AS suppressed MEP amplitude at ISIs of 30-80 ms. By contrast, H-reflex amplitude was augmented at ISIs of 100-200 ms. In conclusions, acoustic stimulation exerts opposite and ISI-specific effects on the amplitude of MEPs and H-reflex in the SOL muscle, indicating different mechanism of auditory-to-motor interactions at cortical and spinal level of motor system.

KW - Acoustic Stimulation

KW - Adult

KW - Analysis of Variance

KW - Cerebral Cortex

KW - Electromyography

KW - Evoked Potentials, Motor

KW - Female

KW - Germany

KW - H-Reflex

KW - Humans

KW - Lower Extremity

KW - Male

KW - Motor Neurons

KW - Muscle, Skeletal

KW - Neural Inhibition

KW - Reflex, Startle

KW - Spinal Nerves

KW - Time Factors

KW - Transcranial Magnetic Stimulation

KW - Journal Article

KW - Randomized Controlled Trial

M3 - SCORING: Journal article

C2 - 21777020

VL - 60 Suppl 1

SP - S101-6

JO - PHYSIOL RES

JF - PHYSIOL RES

SN - 0862-8408

ER -