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Start a fire, kill the bug

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Start a fire, kill the bug : The role of platelets in inflammation and infection. / Deppermann, Carsten; Kubes, Paul.

in: INNATE IMMUN-LONDON, Jahrgang 24, Nr. 6, 08.2018, S. 335-348.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Deppermann, C & Kubes, P 2018, 'Start a fire, kill the bug: The role of platelets in inflammation and infection', INNATE IMMUN-LONDON, Jg. 24, Nr. 6, S. 335-348. https://doi.org/10.1177/1753425918789255

APA

Deppermann, C., & Kubes, P. (2018). Start a fire, kill the bug: The role of platelets in inflammation and infection. INNATE IMMUN-LONDON, 24(6), 335-348. https://doi.org/10.1177/1753425918789255

Vancouver

Deppermann C, Kubes P. Start a fire, kill the bug: The role of platelets in inflammation and infection. INNATE IMMUN-LONDON. 2018 Aug;24(6):335-348. https://doi.org/10.1177/1753425918789255

Bibtex

@article{c2c5fd49cc1f496f95a559fd3282dc30,
title = "Start a fire, kill the bug: The role of platelets in inflammation and infection",
abstract = "Platelets are the main players in thrombosis and hemostasis; however they also play important roles during inflammation and infection. Through their surface receptors, platelets can directly interact with pathogens and immune cells. Platelets form complexes with neutrophils to modulate their capacities to produce reactive oxygen species or form neutrophil extracellular traps. Furthermore, they release microbicidal factors and cytokines that kill pathogens and influence the immune response, respectively. Platelets also maintain the vascular integrity during inflammation by a mechanism that is different from classical platelet activation. In this review we summarize the current knowledge about how platelets interact with the innate immune system during inflammation and infection and highlight recent advances in the field.",
keywords = "Animals, Blood Platelets/immunology, Cytokines/metabolism, Extracellular Traps, Humans, Immunity, Innate, Infections/immunology, Inflammation/immunology, Neutrophils/immunology, Reactive Oxygen Species/metabolism",
author = "Carsten Deppermann and Paul Kubes",
year = "2018",
month = aug,
doi = "10.1177/1753425918789255",
language = "English",
volume = "24",
pages = "335--348",
journal = "INNATE IMMUN-LONDON",
issn = "1753-4259",
publisher = "SAGE Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Start a fire, kill the bug

T2 - The role of platelets in inflammation and infection

AU - Deppermann, Carsten

AU - Kubes, Paul

PY - 2018/8

Y1 - 2018/8

N2 - Platelets are the main players in thrombosis and hemostasis; however they also play important roles during inflammation and infection. Through their surface receptors, platelets can directly interact with pathogens and immune cells. Platelets form complexes with neutrophils to modulate their capacities to produce reactive oxygen species or form neutrophil extracellular traps. Furthermore, they release microbicidal factors and cytokines that kill pathogens and influence the immune response, respectively. Platelets also maintain the vascular integrity during inflammation by a mechanism that is different from classical platelet activation. In this review we summarize the current knowledge about how platelets interact with the innate immune system during inflammation and infection and highlight recent advances in the field.

AB - Platelets are the main players in thrombosis and hemostasis; however they also play important roles during inflammation and infection. Through their surface receptors, platelets can directly interact with pathogens and immune cells. Platelets form complexes with neutrophils to modulate their capacities to produce reactive oxygen species or form neutrophil extracellular traps. Furthermore, they release microbicidal factors and cytokines that kill pathogens and influence the immune response, respectively. Platelets also maintain the vascular integrity during inflammation by a mechanism that is different from classical platelet activation. In this review we summarize the current knowledge about how platelets interact with the innate immune system during inflammation and infection and highlight recent advances in the field.

KW - Animals

KW - Blood Platelets/immunology

KW - Cytokines/metabolism

KW - Extracellular Traps

KW - Humans

KW - Immunity, Innate

KW - Infections/immunology

KW - Inflammation/immunology

KW - Neutrophils/immunology

KW - Reactive Oxygen Species/metabolism

U2 - 10.1177/1753425918789255

DO - 10.1177/1753425918789255

M3 - SCORING: Review article

C2 - 30049243

VL - 24

SP - 335

EP - 348

JO - INNATE IMMUN-LONDON

JF - INNATE IMMUN-LONDON

SN - 1753-4259

IS - 6

ER -