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Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.

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Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. / Helms, M W; Kemming, Dirk; Pospisil, H; Vogt, U; Buerger, H; Korsching, E; Liedtke, C; Schlotter, C M; Wang, A; Chan, S Y; Brandt, Burkhard.

in: BRIT J CANCER, Jahrgang 99, Nr. 5, 5, 2008, S. 774-780.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Helms, MW, Kemming, D, Pospisil, H, Vogt, U, Buerger, H, Korsching, E, Liedtke, C, Schlotter, CM, Wang, A, Chan, SY & Brandt, B 2008, 'Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.', BRIT J CANCER, Jg. 99, Nr. 5, 5, S. 774-780. <http://www.ncbi.nlm.nih.gov/pubmed/18728668?dopt=Citation>

APA

Helms, M. W., Kemming, D., Pospisil, H., Vogt, U., Buerger, H., Korsching, E., Liedtke, C., Schlotter, C. M., Wang, A., Chan, S. Y., & Brandt, B. (2008). Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. BRIT J CANCER, 99(5), 774-780. [5]. http://www.ncbi.nlm.nih.gov/pubmed/18728668?dopt=Citation

Vancouver

Helms MW, Kemming D, Pospisil H, Vogt U, Buerger H, Korsching E et al. Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. BRIT J CANCER. 2008;99(5):774-780. 5.

Bibtex

@article{d6625488b6094430ab8dd722578189f0,
title = "Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.",
abstract = "Gains of chromosomes 7p and 8q are associated with poor prognosis among oestrogen receptor-positive (ER+) stage I/II breast cancer. To identify transcriptional changes associated with this breast cancer subtype, we applied suppression subtractive hybridisation method to analyse differentially expressed genes among six breast tumours with and without chromosomal 7p and 8q gains. Identified mRNAs were validated by real-time RT-PCR in tissue samples obtained from 186 patients with stage I/II breast cancer. Advanced statistical methods were applied to identify associations of mRNA expression with distant metastasis-free survival (DMFS). mRNA expression of the key enzyme of cholesterol biosynthesis, squalene epoxidase (SQLE, chromosomal location 8q24.1), was associated with ER+ 7p+/8q+ breast cancer. Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox analysis (P",
author = "Helms, {M W} and Dirk Kemming and H Pospisil and U Vogt and H Buerger and E Korsching and C Liedtke and Schlotter, {C M} and A Wang and Chan, {S Y} and Burkhard Brandt",
year = "2008",
language = "Deutsch",
volume = "99",
pages = "774--780",
journal = "BRIT J CANCER",
issn = "0007-0920",
publisher = "NATURE PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.

AU - Helms, M W

AU - Kemming, Dirk

AU - Pospisil, H

AU - Vogt, U

AU - Buerger, H

AU - Korsching, E

AU - Liedtke, C

AU - Schlotter, C M

AU - Wang, A

AU - Chan, S Y

AU - Brandt, Burkhard

PY - 2008

Y1 - 2008

N2 - Gains of chromosomes 7p and 8q are associated with poor prognosis among oestrogen receptor-positive (ER+) stage I/II breast cancer. To identify transcriptional changes associated with this breast cancer subtype, we applied suppression subtractive hybridisation method to analyse differentially expressed genes among six breast tumours with and without chromosomal 7p and 8q gains. Identified mRNAs were validated by real-time RT-PCR in tissue samples obtained from 186 patients with stage I/II breast cancer. Advanced statistical methods were applied to identify associations of mRNA expression with distant metastasis-free survival (DMFS). mRNA expression of the key enzyme of cholesterol biosynthesis, squalene epoxidase (SQLE, chromosomal location 8q24.1), was associated with ER+ 7p+/8q+ breast cancer. Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox analysis (P

AB - Gains of chromosomes 7p and 8q are associated with poor prognosis among oestrogen receptor-positive (ER+) stage I/II breast cancer. To identify transcriptional changes associated with this breast cancer subtype, we applied suppression subtractive hybridisation method to analyse differentially expressed genes among six breast tumours with and without chromosomal 7p and 8q gains. Identified mRNAs were validated by real-time RT-PCR in tissue samples obtained from 186 patients with stage I/II breast cancer. Advanced statistical methods were applied to identify associations of mRNA expression with distant metastasis-free survival (DMFS). mRNA expression of the key enzyme of cholesterol biosynthesis, squalene epoxidase (SQLE, chromosomal location 8q24.1), was associated with ER+ 7p+/8q+ breast cancer. Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox analysis (P

M3 - SCORING: Zeitschriftenaufsatz

VL - 99

SP - 774

EP - 780

JO - BRIT J CANCER

JF - BRIT J CANCER

SN - 0007-0920

IS - 5

M1 - 5

ER -