Spätfolgen einer Krebsbehandlung im Kindes- und Jugendalter
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Spätfolgen einer Krebsbehandlung im Kindes- und Jugendalter : Eine Herausforderung für die Transitionsmedizin. / Gebauer, J; Lehnert, H; Schmid, S M; Spix, C; Stein, A; Langer, T.
in: INTERNIST, Jahrgang 59, Nr. 11, 11.2018, S. 1157-1162.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Lehre
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TY - JOUR
T1 - Spätfolgen einer Krebsbehandlung im Kindes- und Jugendalter
T2 - Eine Herausforderung für die Transitionsmedizin
AU - Gebauer, J
AU - Lehnert, H
AU - Schmid, S M
AU - Spix, C
AU - Stein, A
AU - Langer, T
PY - 2018/11
Y1 - 2018/11
N2 - BACKGROUND: Childhood cancer survivors are at risk of cancer- and treatment-related chronic health conditions. Since these sequelae may occur years after the end of treatment, many patients are already adults and have completed pediatric oncological care. Thus, successful transition is essential in order to ensure long-term surveillance.OBJECTIVES: The present review outlines the most frequent late effects of childhood cancer treatment. Moreover, difficulties in transition of these patients are discussed and interdisciplinary models of care are presented.RESULTS: Late effects following childhood cancer treatment occur in over two thirds of patients 30 years after the end of the oncological treatment and can affect different organs. The most frequent sequelae are endocrine disturbances, cardiac conditions, and subsequent neoplasms. Many late effects are effectively manageable if detected early. This necessitates an interdisciplinary approach as well as life-long surveillance.CONCLUSIONS: Transition from pediatric to internal medicine care as well as a change in the focus of care, shifting from relapse centered follow-up to late-effects centered surveillance, constitute a special challenge for a successful transition of long-term childhood cancer survivors. Specialized late-effects survivorship clinics offering interdisciplinary care from pediatric oncologists, specialists of internal medicine, and further disciplines enable the early diagnosis and treatment of late-effects.
AB - BACKGROUND: Childhood cancer survivors are at risk of cancer- and treatment-related chronic health conditions. Since these sequelae may occur years after the end of treatment, many patients are already adults and have completed pediatric oncological care. Thus, successful transition is essential in order to ensure long-term surveillance.OBJECTIVES: The present review outlines the most frequent late effects of childhood cancer treatment. Moreover, difficulties in transition of these patients are discussed and interdisciplinary models of care are presented.RESULTS: Late effects following childhood cancer treatment occur in over two thirds of patients 30 years after the end of the oncological treatment and can affect different organs. The most frequent sequelae are endocrine disturbances, cardiac conditions, and subsequent neoplasms. Many late effects are effectively manageable if detected early. This necessitates an interdisciplinary approach as well as life-long surveillance.CONCLUSIONS: Transition from pediatric to internal medicine care as well as a change in the focus of care, shifting from relapse centered follow-up to late-effects centered surveillance, constitute a special challenge for a successful transition of long-term childhood cancer survivors. Specialized late-effects survivorship clinics offering interdisciplinary care from pediatric oncologists, specialists of internal medicine, and further disciplines enable the early diagnosis and treatment of late-effects.
KW - English Abstract
KW - Journal Article
KW - Review
U2 - 10.1007/s00108-018-0496-0
DO - 10.1007/s00108-018-0496-0
M3 - SCORING: Review
C2 - 30229367
VL - 59
SP - 1157
EP - 1162
JO - INTERNIST
JF - INTERNIST
SN - 0020-9554
IS - 11
ER -