Source localization and possible causes of interictal epileptic activity in tumor-associated epilepsy.
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Source localization and possible causes of interictal epileptic activity in tumor-associated epilepsy. / Patt, S; Steenbeck, J; Hochstetter, A; Kraft, R; Huonker, R; Haueisen, J; Haberland, N; Ebmeier, K; Hliscs, R; Fiehler, Jens; Nowak, H; Kalff, R.
in: NEUROBIOL DIS, Jahrgang 7, Nr. 4, 4, 2000, S. 260-269.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Source localization and possible causes of interictal epileptic activity in tumor-associated epilepsy.
AU - Patt, S
AU - Steenbeck, J
AU - Hochstetter, A
AU - Kraft, R
AU - Huonker, R
AU - Haueisen, J
AU - Haberland, N
AU - Ebmeier, K
AU - Hliscs, R
AU - Fiehler, Jens
AU - Nowak, H
AU - Kalff, R
PY - 2000
Y1 - 2000
N2 - Electrophysiological studies in gliomas have demonstrated action potentials in neoplastic cells. These "spiking tumor cells" are, however, an enigma. In attempt to find evidences for spikes within tumoral borders, 21 patients with different intracerebral tumors were preoperatively screened for the occurrence of epileptogenic discharges using multichannel MEG and EEG. A correlation between histopathology and the distance between dipole and tumor border could be found. Glioma patients showed epileptic activities closer to the border than those with mixed glioneuronal neoplasms and metastases. Four glioma patients demonstrated epileptic activity within the tumor boundary, however, not in the deep center of the tumor. Patch-clamping of cells from acute glioma slices did not yield a correlation between the presence of voltage-gated sodium channels in tumor cells and the MEG/EEG data. Our results demonstrate that the zone with the highest epileptogenic potential is different in gliomas and other brain tumors. However, our data do not strongly suggest that glioma cells are directly involved in the generation of tumor-associated epilepsy in vivo via their capability to generate action potentials.
AB - Electrophysiological studies in gliomas have demonstrated action potentials in neoplastic cells. These "spiking tumor cells" are, however, an enigma. In attempt to find evidences for spikes within tumoral borders, 21 patients with different intracerebral tumors were preoperatively screened for the occurrence of epileptogenic discharges using multichannel MEG and EEG. A correlation between histopathology and the distance between dipole and tumor border could be found. Glioma patients showed epileptic activities closer to the border than those with mixed glioneuronal neoplasms and metastases. Four glioma patients demonstrated epileptic activity within the tumor boundary, however, not in the deep center of the tumor. Patch-clamping of cells from acute glioma slices did not yield a correlation between the presence of voltage-gated sodium channels in tumor cells and the MEG/EEG data. Our results demonstrate that the zone with the highest epileptogenic potential is different in gliomas and other brain tumors. However, our data do not strongly suggest that glioma cells are directly involved in the generation of tumor-associated epilepsy in vivo via their capability to generate action potentials.
M3 - SCORING: Zeitschriftenaufsatz
VL - 7
SP - 260
EP - 269
JO - NEUROBIOL DIS
JF - NEUROBIOL DIS
SN - 0969-9961
IS - 4
M1 - 4
ER -
