Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke.

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Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke. / Celnik, Pablo; Hummel, Friedhelm; Harris-Love, Michelle; Wolk, Rebecca; Cohen, Leonardo G.

in: ARCH PHYS MED REHAB, Jahrgang 88, Nr. 11, 11, 2007, S. 1369-1376.

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@article{379026352f9648c1a06327f9b2cfacbb,
title = "Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke.",
abstract = "OBJECTIVE: To test the hypothesis that somatosensory stimulation would enhance the effects of training functional hand tasks immediately after practice and 1 day later in chronic subcortical stroke patients. DESIGN: Single-blinded and randomized, crossover study. SETTING: Human research laboratory. PARTICIPANTS: Nine chronic subcortical stroke patients. INTERVENTIONS: Three separate sessions of motor training preceded by (1) synchronous peripheral nerve stimulation (PNS), (2) no stimulation, or (3) asynchronous PNS. MAIN OUTCOME MEASURES: Time to complete the Jebsen-Taylor Hand Function Test (JTHFT time) and corticomotor excitability tested with transcranial magnetic stimulation. RESULTS: After familiarization practice, during which all patients reached a performance plateau, training under the effects of PNS reduced JTHFT time by 10% beyond the post-familiarization plateau. This behavioral gain was accompanied by a specific reduction in GABAergically mediated intracortical inhibition in the motor cortex. These findings were not observed after similar practice under the influence of no stimulation or asynchronous PNS sessions. CONCLUSIONS: Somatosensory stimulation may enhance the training of functional hand tasks in patients with chronic stroke, possibly through modulation of intracortical GABAergic pathways.",
author = "Pablo Celnik and Friedhelm Hummel and Michelle Harris-Love and Rebecca Wolk and Cohen, {Leonardo G}",
year = "2007",
language = "Deutsch",
volume = "88",
pages = "1369--1376",
journal = "ARCH PHYS MED REHAB",
issn = "0003-9993",
publisher = "W.B. Saunders Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke.

AU - Celnik, Pablo

AU - Hummel, Friedhelm

AU - Harris-Love, Michelle

AU - Wolk, Rebecca

AU - Cohen, Leonardo G

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: To test the hypothesis that somatosensory stimulation would enhance the effects of training functional hand tasks immediately after practice and 1 day later in chronic subcortical stroke patients. DESIGN: Single-blinded and randomized, crossover study. SETTING: Human research laboratory. PARTICIPANTS: Nine chronic subcortical stroke patients. INTERVENTIONS: Three separate sessions of motor training preceded by (1) synchronous peripheral nerve stimulation (PNS), (2) no stimulation, or (3) asynchronous PNS. MAIN OUTCOME MEASURES: Time to complete the Jebsen-Taylor Hand Function Test (JTHFT time) and corticomotor excitability tested with transcranial magnetic stimulation. RESULTS: After familiarization practice, during which all patients reached a performance plateau, training under the effects of PNS reduced JTHFT time by 10% beyond the post-familiarization plateau. This behavioral gain was accompanied by a specific reduction in GABAergically mediated intracortical inhibition in the motor cortex. These findings were not observed after similar practice under the influence of no stimulation or asynchronous PNS sessions. CONCLUSIONS: Somatosensory stimulation may enhance the training of functional hand tasks in patients with chronic stroke, possibly through modulation of intracortical GABAergic pathways.

AB - OBJECTIVE: To test the hypothesis that somatosensory stimulation would enhance the effects of training functional hand tasks immediately after practice and 1 day later in chronic subcortical stroke patients. DESIGN: Single-blinded and randomized, crossover study. SETTING: Human research laboratory. PARTICIPANTS: Nine chronic subcortical stroke patients. INTERVENTIONS: Three separate sessions of motor training preceded by (1) synchronous peripheral nerve stimulation (PNS), (2) no stimulation, or (3) asynchronous PNS. MAIN OUTCOME MEASURES: Time to complete the Jebsen-Taylor Hand Function Test (JTHFT time) and corticomotor excitability tested with transcranial magnetic stimulation. RESULTS: After familiarization practice, during which all patients reached a performance plateau, training under the effects of PNS reduced JTHFT time by 10% beyond the post-familiarization plateau. This behavioral gain was accompanied by a specific reduction in GABAergically mediated intracortical inhibition in the motor cortex. These findings were not observed after similar practice under the influence of no stimulation or asynchronous PNS sessions. CONCLUSIONS: Somatosensory stimulation may enhance the training of functional hand tasks in patients with chronic stroke, possibly through modulation of intracortical GABAergic pathways.

M3 - SCORING: Zeitschriftenaufsatz

VL - 88

SP - 1369

EP - 1376

JO - ARCH PHYS MED REHAB

JF - ARCH PHYS MED REHAB

SN - 0003-9993

IS - 11

M1 - 11

ER -