Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke.
Standard
Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke. / Celnik, Pablo; Hummel, Friedhelm; Harris-Love, Michelle; Wolk, Rebecca; Cohen, Leonardo G.
in: ARCH PHYS MED REHAB, Jahrgang 88, Nr. 11, 11, 2007, S. 1369-1376.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke.
AU - Celnik, Pablo
AU - Hummel, Friedhelm
AU - Harris-Love, Michelle
AU - Wolk, Rebecca
AU - Cohen, Leonardo G
PY - 2007
Y1 - 2007
N2 - OBJECTIVE: To test the hypothesis that somatosensory stimulation would enhance the effects of training functional hand tasks immediately after practice and 1 day later in chronic subcortical stroke patients. DESIGN: Single-blinded and randomized, crossover study. SETTING: Human research laboratory. PARTICIPANTS: Nine chronic subcortical stroke patients. INTERVENTIONS: Three separate sessions of motor training preceded by (1) synchronous peripheral nerve stimulation (PNS), (2) no stimulation, or (3) asynchronous PNS. MAIN OUTCOME MEASURES: Time to complete the Jebsen-Taylor Hand Function Test (JTHFT time) and corticomotor excitability tested with transcranial magnetic stimulation. RESULTS: After familiarization practice, during which all patients reached a performance plateau, training under the effects of PNS reduced JTHFT time by 10% beyond the post-familiarization plateau. This behavioral gain was accompanied by a specific reduction in GABAergically mediated intracortical inhibition in the motor cortex. These findings were not observed after similar practice under the influence of no stimulation or asynchronous PNS sessions. CONCLUSIONS: Somatosensory stimulation may enhance the training of functional hand tasks in patients with chronic stroke, possibly through modulation of intracortical GABAergic pathways.
AB - OBJECTIVE: To test the hypothesis that somatosensory stimulation would enhance the effects of training functional hand tasks immediately after practice and 1 day later in chronic subcortical stroke patients. DESIGN: Single-blinded and randomized, crossover study. SETTING: Human research laboratory. PARTICIPANTS: Nine chronic subcortical stroke patients. INTERVENTIONS: Three separate sessions of motor training preceded by (1) synchronous peripheral nerve stimulation (PNS), (2) no stimulation, or (3) asynchronous PNS. MAIN OUTCOME MEASURES: Time to complete the Jebsen-Taylor Hand Function Test (JTHFT time) and corticomotor excitability tested with transcranial magnetic stimulation. RESULTS: After familiarization practice, during which all patients reached a performance plateau, training under the effects of PNS reduced JTHFT time by 10% beyond the post-familiarization plateau. This behavioral gain was accompanied by a specific reduction in GABAergically mediated intracortical inhibition in the motor cortex. These findings were not observed after similar practice under the influence of no stimulation or asynchronous PNS sessions. CONCLUSIONS: Somatosensory stimulation may enhance the training of functional hand tasks in patients with chronic stroke, possibly through modulation of intracortical GABAergic pathways.
M3 - SCORING: Zeitschriftenaufsatz
VL - 88
SP - 1369
EP - 1376
JO - ARCH PHYS MED REHAB
JF - ARCH PHYS MED REHAB
SN - 0003-9993
IS - 11
M1 - 11
ER -