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Somatische RET-Protoonkogenmutationen bei sporadischem C-Zell-Carcinom der Schilddrüse

Standard

Somatische RET-Protoonkogenmutationen bei sporadischem C-Zell-Carcinom der Schilddrüse. / Frilling, A; Bockhorn, M; Kalinin, V; Liedke, M; Kaun, M; Broelsch, C E.

in: CHIRURG, Jahrgang 68, Nr. 8, 01.08.1997, S. 789-93.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Frilling, A, Bockhorn, M, Kalinin, V, Liedke, M, Kaun, M & Broelsch, CE 1997, 'Somatische RET-Protoonkogenmutationen bei sporadischem C-Zell-Carcinom der Schilddrüse', CHIRURG, Jg. 68, Nr. 8, S. 789-93.

APA

Frilling, A., Bockhorn, M., Kalinin, V., Liedke, M., Kaun, M., & Broelsch, C. E. (1997). Somatische RET-Protoonkogenmutationen bei sporadischem C-Zell-Carcinom der Schilddrüse. CHIRURG, 68(8), 789-93.

Vancouver

Frilling A, Bockhorn M, Kalinin V, Liedke M, Kaun M, Broelsch CE. Somatische RET-Protoonkogenmutationen bei sporadischem C-Zell-Carcinom der Schilddrüse. CHIRURG. 1997 Aug 1;68(8):789-93.

Bibtex

@article{e9535b036a2449e088b3741fc023826c,
title = "Somatische RET-Protoonkogenmutationen bei sporadischem C-Zell-Carcinom der Schilddr{\"u}se",
abstract = "Germline mutations of the RET proto-oncogene localized on chromosome 10q11.2 are the underlying cause of hereditary medullary thyroid carcinoma. In MEN 2A and FMTC, mutations can be found in exons 10, 11, 13 or 14. MEN 2B is characterized by a specific mutation in exon 16. In a significant number of sporadic MTC somatic mutations in codon 918 (exon 16) are detectable. Some rare sporadic MTC present somatic mutations in codons 611, 634, 768 and 883. Recently, deletion-insertion of the RET proto-oncogene in exon 11 and a deletion in exon 10 has been found. RET proto-oncogene mutations are not only responsible for the development of the familial MTC, but may also play an important role in the pathogenesis of sporadic MTC. However, the prognostic relevance of these somatic events is still unclear.",
keywords = "Carcinoma, Medullary, Cell Transformation, Neoplastic, Chromosome Deletion, Chromosomes, Human, Pair 10, Codon, DNA Mutational Analysis, DNA, Neoplasm, Drosophila Proteins, Exons, Germ-Line Mutation, Humans, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2b, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ret, Receptor Protein-Tyrosine Kinases, Thyroid Gland, Thyroid Neoplasms, Thyroidectomy",
author = "A Frilling and M Bockhorn and V Kalinin and M Liedke and M Kaun and Broelsch, {C E}",
year = "1997",
month = aug,
day = "1",
language = "Deutsch",
volume = "68",
pages = "789--93",
journal = "CHIRURG",
issn = "0009-4722",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Somatische RET-Protoonkogenmutationen bei sporadischem C-Zell-Carcinom der Schilddrüse

AU - Frilling, A

AU - Bockhorn, M

AU - Kalinin, V

AU - Liedke, M

AU - Kaun, M

AU - Broelsch, C E

PY - 1997/8/1

Y1 - 1997/8/1

N2 - Germline mutations of the RET proto-oncogene localized on chromosome 10q11.2 are the underlying cause of hereditary medullary thyroid carcinoma. In MEN 2A and FMTC, mutations can be found in exons 10, 11, 13 or 14. MEN 2B is characterized by a specific mutation in exon 16. In a significant number of sporadic MTC somatic mutations in codon 918 (exon 16) are detectable. Some rare sporadic MTC present somatic mutations in codons 611, 634, 768 and 883. Recently, deletion-insertion of the RET proto-oncogene in exon 11 and a deletion in exon 10 has been found. RET proto-oncogene mutations are not only responsible for the development of the familial MTC, but may also play an important role in the pathogenesis of sporadic MTC. However, the prognostic relevance of these somatic events is still unclear.

AB - Germline mutations of the RET proto-oncogene localized on chromosome 10q11.2 are the underlying cause of hereditary medullary thyroid carcinoma. In MEN 2A and FMTC, mutations can be found in exons 10, 11, 13 or 14. MEN 2B is characterized by a specific mutation in exon 16. In a significant number of sporadic MTC somatic mutations in codon 918 (exon 16) are detectable. Some rare sporadic MTC present somatic mutations in codons 611, 634, 768 and 883. Recently, deletion-insertion of the RET proto-oncogene in exon 11 and a deletion in exon 10 has been found. RET proto-oncogene mutations are not only responsible for the development of the familial MTC, but may also play an important role in the pathogenesis of sporadic MTC. However, the prognostic relevance of these somatic events is still unclear.

KW - Carcinoma, Medullary

KW - Cell Transformation, Neoplastic

KW - Chromosome Deletion

KW - Chromosomes, Human, Pair 10

KW - Codon

KW - DNA Mutational Analysis

KW - DNA, Neoplasm

KW - Drosophila Proteins

KW - Exons

KW - Germ-Line Mutation

KW - Humans

KW - Multiple Endocrine Neoplasia Type 1

KW - Multiple Endocrine Neoplasia Type 2b

KW - Prognosis

KW - Proto-Oncogene Proteins

KW - Proto-Oncogene Proteins c-ret

KW - Receptor Protein-Tyrosine Kinases

KW - Thyroid Gland

KW - Thyroid Neoplasms

KW - Thyroidectomy

M3 - SCORING: Zeitschriftenaufsatz

C2 - 9377989

VL - 68

SP - 789

EP - 793

JO - CHIRURG

JF - CHIRURG

SN - 0009-4722

IS - 8

ER -