Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study.
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Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. / Lewczuk, P; Kamrowski-Kruck, H; Peters, O; Heuser, I; Jessen, F; Popp, J; Bürger, K; Hampel, H; Frölich, L; Wolf, S; Prinz, B; Jahn, Holger; Luckhaus, Ch; Perneczky, R; Hüll, M; Schröder, J; Kessler, H; Pantel, J; Gertz, H-J; Klafki, H-W; Kölsch, H; Reulbach, U; Esselmann, H; Maler, J M; Bibl, M; Kornhuber, J; Wiltfang, J.
in: MOL PSYCHIATR, 2008.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study.
AU - Lewczuk, P
AU - Kamrowski-Kruck, H
AU - Peters, O
AU - Heuser, I
AU - Jessen, F
AU - Popp, J
AU - Bürger, K
AU - Hampel, H
AU - Frölich, L
AU - Wolf, S
AU - Prinz, B
AU - Jahn, Holger
AU - Luckhaus, Ch
AU - Perneczky, R
AU - Hüll, M
AU - Schröder, J
AU - Kessler, H
AU - Pantel, J
AU - Gertz, H-J
AU - Klafki, H-W
AU - Kölsch, H
AU - Reulbach, U
AU - Esselmann, H
AU - Maler, J M
AU - Bibl, M
AU - Kornhuber, J
AU - Wiltfang, J
PY - 2008
Y1 - 2008
N2 - In this report, we present the results of a multicenter study to test analytic and diagnostic performance of soluble forms of amyloid precursor proteins alpha and beta (sAPPalpha and sAPPbeta) in the cerebrospinal fluid (CSF) of patients with different forms of dementing conditions. CSF samples were collected from 188 patients with early dementia (mini-mental state examination>/=20 in majority of cases) and mild cognitive impairment (MCI) in 12 gerontopsychiatric centers, and the clinical diagnoses were supported by neurochemical dementia diagnostic (NDD) tools: CSF amyloidbeta peptides, Tau and phospho-Tau. sAPPalpha and sAPPbeta were measured with multiplexing method based on electrochemiluminescence. sAPPalpha and sAPPbeta CSF concentrations correlated with each other with very high correlation ratio (R=0.96, P
AB - In this report, we present the results of a multicenter study to test analytic and diagnostic performance of soluble forms of amyloid precursor proteins alpha and beta (sAPPalpha and sAPPbeta) in the cerebrospinal fluid (CSF) of patients with different forms of dementing conditions. CSF samples were collected from 188 patients with early dementia (mini-mental state examination>/=20 in majority of cases) and mild cognitive impairment (MCI) in 12 gerontopsychiatric centers, and the clinical diagnoses were supported by neurochemical dementia diagnostic (NDD) tools: CSF amyloidbeta peptides, Tau and phospho-Tau. sAPPalpha and sAPPbeta were measured with multiplexing method based on electrochemiluminescence. sAPPalpha and sAPPbeta CSF concentrations correlated with each other with very high correlation ratio (R=0.96, P
M3 - SCORING: Zeitschriftenaufsatz
JO - MOL PSYCHIATR
JF - MOL PSYCHIATR
SN - 1359-4184
ER -