Soft tissue sarcomas of the extremities and trunk in the adult. Report of 124 cases.
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Soft tissue sarcomas of the extremities and trunk in the adult. Report of 124 cases. / Zornig, C; Weh, H J; Krüll, Andreas; Schwarz, R; Hilgert, R E; Schröder, S.
in: LANGENBECK ARCH SURG, Jahrgang 377, Nr. 1, 1, 1992, S. 28-33.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Soft tissue sarcomas of the extremities and trunk in the adult. Report of 124 cases.
AU - Zornig, C
AU - Weh, H J
AU - Krüll, Andreas
AU - Schwarz, R
AU - Hilgert, R E
AU - Schröder, S
PY - 1992
Y1 - 1992
N2 - Between 1970 and 1988 surgery was performed on 124 patients with soft tissue sarcomas of the extremities and trunk in the University Clinics of Hamburg. Liposarcoma, malignant fibrous histiocytoma, fibrosarcoma and malignant schwannoma were the most common histological types. High-grade sarcomas (G3) predominated, with 41%, while 26% were graded G2 and 33% G1. Resection with wide margins all round was achieved in only 54% of the patients. The quality of the operation proved to be only therapy-related prognostic factor. In addition, tumour grade, size, regional lymph node and distant metastasis and histological type proved to be relevant to the prognosis. With multivariate analysis, distant metastasis, grade, resectability and histological type retained prognostic significance. The efficacy of adjuvant chemo- and radiotherapy was related to the quality of the preceding tumour resection. In case of gross tumour the rate of either partial or complete response was 28% for chemotherapy and 22% for radiotherapy. The mean survival time was 102 months; the 5- and 10-year survival rates were 48% and 37%, respectively.
AB - Between 1970 and 1988 surgery was performed on 124 patients with soft tissue sarcomas of the extremities and trunk in the University Clinics of Hamburg. Liposarcoma, malignant fibrous histiocytoma, fibrosarcoma and malignant schwannoma were the most common histological types. High-grade sarcomas (G3) predominated, with 41%, while 26% were graded G2 and 33% G1. Resection with wide margins all round was achieved in only 54% of the patients. The quality of the operation proved to be only therapy-related prognostic factor. In addition, tumour grade, size, regional lymph node and distant metastasis and histological type proved to be relevant to the prognosis. With multivariate analysis, distant metastasis, grade, resectability and histological type retained prognostic significance. The efficacy of adjuvant chemo- and radiotherapy was related to the quality of the preceding tumour resection. In case of gross tumour the rate of either partial or complete response was 28% for chemotherapy and 22% for radiotherapy. The mean survival time was 102 months; the 5- and 10-year survival rates were 48% and 37%, respectively.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Adolescent
KW - Lymphatic Metastasis
KW - Survival Rate
KW - Follow-Up Studies
KW - Combined Modality Therapy
KW - Extremities/surgery
KW - Neoplasm Recurrence, Local/drug therapy/mortality/radiotherapy/surgery
KW - Sarcoma/drug therapy/mortality/radiotherapy/surgery
KW - Soft Tissue Neoplasms/drug therapy/mortality/radiotherapy/surgery
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Adolescent
KW - Lymphatic Metastasis
KW - Survival Rate
KW - Follow-Up Studies
KW - Combined Modality Therapy
KW - Extremities/surgery
KW - Neoplasm Recurrence, Local/drug therapy/mortality/radiotherapy/surgery
KW - Sarcoma/drug therapy/mortality/radiotherapy/surgery
KW - Soft Tissue Neoplasms/drug therapy/mortality/radiotherapy/surgery
M3 - SCORING: Journal article
VL - 377
SP - 28
EP - 33
JO - LANGENBECK ARCH SURG
JF - LANGENBECK ARCH SURG
SN - 1435-2443
IS - 1
M1 - 1
ER -
