Smoking does not Alter the Therapy Response to Systemic Anti-psoriatic Therapies - A Two-country, Multi-centre, Prospective, Non-interventional Study
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Smoking does not Alter the Therapy Response to Systemic Anti-psoriatic Therapies - A Two-country, Multi-centre, Prospective, Non-interventional Study. / Anzengruber, Florian; Augustin, Matthias; Radtke, Marc A; Thaci, Diamant; Yawalkar, Nikhil; Streit, Markus; Reich, Kristian; Drach, Mathias; Sorbe, Christina; French, Lars E; Mrowietz, Ulrich; Maul, Julia-Tatjana; Itin, Peter H; Navarini, Alexander A.
in: ACTA DERM-VENEREOL, Jahrgang 99, Nr. 10, 01.09.2019, S. 871-877.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Smoking does not Alter the Therapy Response to Systemic Anti-psoriatic Therapies - A Two-country, Multi-centre, Prospective, Non-interventional Study
AU - Anzengruber, Florian
AU - Augustin, Matthias
AU - Radtke, Marc A
AU - Thaci, Diamant
AU - Yawalkar, Nikhil
AU - Streit, Markus
AU - Reich, Kristian
AU - Drach, Mathias
AU - Sorbe, Christina
AU - French, Lars E
AU - Mrowietz, Ulrich
AU - Maul, Julia-Tatjana
AU - Itin, Peter H
AU - Navarini, Alexander A
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Psoriasis can involve the skin, joints, nails and cardiovascular system and result in a significant impairment in quality of life. Studies have shown a lower response rate to systemic anti-psoriatic therapies in smokers, and smoking is a trigger factor for psoriasis. The aim of this study was therefore to analyse the response to systemic therapies for psoriasis, with a focus on smoking. Prospectively collected data from patients with moderate to severe psoriasis included in the national psoriasis registries for Germany and Switzerland (PsoBest and SDNTT) were analysed. Therapy response was defined as reaching a Psoriasis Area and Severity Index (PASI) reduction of 75%, PASI ≤ 3 or Dermatology Life Quality Index (DLQI) ≤ 1. Out of 5,346 patients included in these registries, 1,264 met the inclusion criteria for this study. In the smoking group, 715 (60.6%) reached therapy response at month 3, compared with 358 (63.7%) in the non-smoking group (p ≤ 0.269), 659 (74.1%) vs. 330 (77%) reached therapy response at month 6 (p ≤ 0.097), and 504 (76.6%) vs. 272 (79.0%) at month 12 (p ≤ 0.611). Therefore, these data do not show that smoking affects the response rate of anti-psoriatic therapy after 3, 6 and 12 months.
AB - Psoriasis can involve the skin, joints, nails and cardiovascular system and result in a significant impairment in quality of life. Studies have shown a lower response rate to systemic anti-psoriatic therapies in smokers, and smoking is a trigger factor for psoriasis. The aim of this study was therefore to analyse the response to systemic therapies for psoriasis, with a focus on smoking. Prospectively collected data from patients with moderate to severe psoriasis included in the national psoriasis registries for Germany and Switzerland (PsoBest and SDNTT) were analysed. Therapy response was defined as reaching a Psoriasis Area and Severity Index (PASI) reduction of 75%, PASI ≤ 3 or Dermatology Life Quality Index (DLQI) ≤ 1. Out of 5,346 patients included in these registries, 1,264 met the inclusion criteria for this study. In the smoking group, 715 (60.6%) reached therapy response at month 3, compared with 358 (63.7%) in the non-smoking group (p ≤ 0.269), 659 (74.1%) vs. 330 (77%) reached therapy response at month 6 (p ≤ 0.097), and 504 (76.6%) vs. 272 (79.0%) at month 12 (p ≤ 0.611). Therefore, these data do not show that smoking affects the response rate of anti-psoriatic therapy after 3, 6 and 12 months.
U2 - 10.2340/00015555-3221
DO - 10.2340/00015555-3221
M3 - SCORING: Journal article
C2 - 31099404
VL - 99
SP - 871
EP - 877
JO - ACTA DERM-VENEREOL
JF - ACTA DERM-VENEREOL
SN - 0001-5555
IS - 10
ER -