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Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings

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Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings. / Buchegger, Sascha; Kamenac, Andrej; Fuchs, Sven; Herrmann, Rudolf; Houdek, Pia; Gorzelanny, Christian; Obermeier, Andreas; Heller, Stephan; Burgkart, Rainer; Stritzker, Bernd; Wixforth, Achim; Westerhausen, Christoph.

in: SCI REP-UK, Jahrgang 9, Nr. 1, 21.11.2019, S. 17246.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Buchegger, S, Kamenac, A, Fuchs, S, Herrmann, R, Houdek, P, Gorzelanny, C, Obermeier, A, Heller, S, Burgkart, R, Stritzker, B, Wixforth, A & Westerhausen, C 2019, 'Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings', SCI REP-UK, Jg. 9, Nr. 1, S. 17246. https://doi.org/10.1038/s41598-019-53521-7

APA

Buchegger, S., Kamenac, A., Fuchs, S., Herrmann, R., Houdek, P., Gorzelanny, C., Obermeier, A., Heller, S., Burgkart, R., Stritzker, B., Wixforth, A., & Westerhausen, C. (2019). Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings. SCI REP-UK, 9(1), 17246. https://doi.org/10.1038/s41598-019-53521-7

Vancouver

Buchegger S, Kamenac A, Fuchs S, Herrmann R, Houdek P, Gorzelanny C et al. Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings. SCI REP-UK. 2019 Nov 21;9(1):17246. https://doi.org/10.1038/s41598-019-53521-7

Bibtex

@article{56f6c8424fdf466faf17e2d028b4691f,
title = "Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings",
abstract = "One of the main challenges in endoprosthesis surgeries are implant-associated infections and aseptic-loosenings, caused by wear debris. To combat these problems, the requirements to surfaces of endoprostheses are wear-resistance, low cytotoxicity and antimicrobial efficacy. We here present antimicrobial coatings with a smart, adaptive release of metal ions in case of infection, based on ZnO-nanoparticles embedded in diamond-like carbon (DLC). The Zn2+ ion release of these coatings in aqueous environments reacts and adapts smartly on inflammations accompanied by acidosis. Moreover, we show that this increased ion release comes along with an increased toxicity to fibroblastic cells (L929) and bacteria (Staphylococcus aureus subsp. aureus, resistant to methicillin and oxacillin. (ATCC 43300, MRSA) and Staphylococcus epidermidis (ATCC 35984, S. epidermidis). Interestingly, the antimicrobial effect and the cytotoxicity of the coatings increase with a reduction of the pH value from 7.4 to 6.4, but not further to pH 5.4.",
author = "Sascha Buchegger and Andrej Kamenac and Sven Fuchs and Rudolf Herrmann and Pia Houdek and Christian Gorzelanny and Andreas Obermeier and Stephan Heller and Rainer Burgkart and Bernd Stritzker and Achim Wixforth and Christoph Westerhausen",
year = "2019",
month = nov,
day = "21",
doi = "10.1038/s41598-019-53521-7",
language = "English",
volume = "9",
pages = "17246",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings

AU - Buchegger, Sascha

AU - Kamenac, Andrej

AU - Fuchs, Sven

AU - Herrmann, Rudolf

AU - Houdek, Pia

AU - Gorzelanny, Christian

AU - Obermeier, Andreas

AU - Heller, Stephan

AU - Burgkart, Rainer

AU - Stritzker, Bernd

AU - Wixforth, Achim

AU - Westerhausen, Christoph

PY - 2019/11/21

Y1 - 2019/11/21

N2 - One of the main challenges in endoprosthesis surgeries are implant-associated infections and aseptic-loosenings, caused by wear debris. To combat these problems, the requirements to surfaces of endoprostheses are wear-resistance, low cytotoxicity and antimicrobial efficacy. We here present antimicrobial coatings with a smart, adaptive release of metal ions in case of infection, based on ZnO-nanoparticles embedded in diamond-like carbon (DLC). The Zn2+ ion release of these coatings in aqueous environments reacts and adapts smartly on inflammations accompanied by acidosis. Moreover, we show that this increased ion release comes along with an increased toxicity to fibroblastic cells (L929) and bacteria (Staphylococcus aureus subsp. aureus, resistant to methicillin and oxacillin. (ATCC 43300, MRSA) and Staphylococcus epidermidis (ATCC 35984, S. epidermidis). Interestingly, the antimicrobial effect and the cytotoxicity of the coatings increase with a reduction of the pH value from 7.4 to 6.4, but not further to pH 5.4.

AB - One of the main challenges in endoprosthesis surgeries are implant-associated infections and aseptic-loosenings, caused by wear debris. To combat these problems, the requirements to surfaces of endoprostheses are wear-resistance, low cytotoxicity and antimicrobial efficacy. We here present antimicrobial coatings with a smart, adaptive release of metal ions in case of infection, based on ZnO-nanoparticles embedded in diamond-like carbon (DLC). The Zn2+ ion release of these coatings in aqueous environments reacts and adapts smartly on inflammations accompanied by acidosis. Moreover, we show that this increased ion release comes along with an increased toxicity to fibroblastic cells (L929) and bacteria (Staphylococcus aureus subsp. aureus, resistant to methicillin and oxacillin. (ATCC 43300, MRSA) and Staphylococcus epidermidis (ATCC 35984, S. epidermidis). Interestingly, the antimicrobial effect and the cytotoxicity of the coatings increase with a reduction of the pH value from 7.4 to 6.4, but not further to pH 5.4.

U2 - 10.1038/s41598-019-53521-7

DO - 10.1038/s41598-019-53521-7

M3 - SCORING: Journal article

C2 - 31754198

VL - 9

SP - 17246

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -