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Small-cell lung cancer (SCLC) cell adhesion on E- and P-selectin under physiological flow conditions

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Small-cell lung cancer (SCLC) cell adhesion on E- and P-selectin under physiological flow conditions. / Richter, Ulrich.

in: Methods Mol Biol, Jahrgang 1070, 01.01.2014, S. 47-56.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Richter, U 2014, 'Small-cell lung cancer (SCLC) cell adhesion on E- and P-selectin under physiological flow conditions', Methods Mol Biol, Jg. 1070, S. 47-56. https://doi.org/10.1007/978-1-4614-8244-4_4

APA

Richter, U. (2014). Small-cell lung cancer (SCLC) cell adhesion on E- and P-selectin under physiological flow conditions. Methods Mol Biol, 1070, 47-56. https://doi.org/10.1007/978-1-4614-8244-4_4

Vancouver

Richter U. Small-cell lung cancer (SCLC) cell adhesion on E- and P-selectin under physiological flow conditions. Methods Mol Biol. 2014 Jan 1;1070:47-56. https://doi.org/10.1007/978-1-4614-8244-4_4

Bibtex

@article{d5c591d0d4d04744b355e11542226d66,
title = "Small-cell lung cancer (SCLC) cell adhesion on E- and P-selectin under physiological flow conditions",
abstract = "Hematogenous metastasis is still a poorly understood phenomenon. The rate-limiting step within the metastatic cascade is not yet clear although it may be estimated that the extravasation of circulating tumor cells is a step of crucial importance, as most tumor cells that are shed into circulation undergo apoptosis. The process of extravasation includes a cascade of consecutive steps, starting with adhesion of tumor cells circulating in the bloodstream to endothelial cells, mimicking leukocyte adhesion and transmigration. Endothelial cell selectin-leukocyte glycan interaction occurs when leukocytes adhere to endothelial cells under conditions of shear stress. As there are parallels between cancer cell endothelial interactions with leukocyte endothelial cell systems an experimental setup has been developed in which adhesion of small cell lung carcinoma adhesive properties can be analyzed under physiological shear stress conditions during their attachment to E- and P-selection.",
keywords = "Animals, Cattle, Cell Adhesion, Cell Culture Techniques, Cell Line, Tumor, E-Selectin, Humans, Lung Neoplasms, P-Selectin, Rheology, Serum Albumin, Bovine, Small Cell Lung Carcinoma",
author = "Ulrich Richter",
year = "2014",
month = jan,
day = "1",
doi = "10.1007/978-1-4614-8244-4_4",
language = "English",
volume = "1070",
pages = "47--56",
journal = "Methods Mol Biol",
issn = "1064-3745",
publisher = "Humana Press",

}

RIS

TY - JOUR

T1 - Small-cell lung cancer (SCLC) cell adhesion on E- and P-selectin under physiological flow conditions

AU - Richter, Ulrich

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Hematogenous metastasis is still a poorly understood phenomenon. The rate-limiting step within the metastatic cascade is not yet clear although it may be estimated that the extravasation of circulating tumor cells is a step of crucial importance, as most tumor cells that are shed into circulation undergo apoptosis. The process of extravasation includes a cascade of consecutive steps, starting with adhesion of tumor cells circulating in the bloodstream to endothelial cells, mimicking leukocyte adhesion and transmigration. Endothelial cell selectin-leukocyte glycan interaction occurs when leukocytes adhere to endothelial cells under conditions of shear stress. As there are parallels between cancer cell endothelial interactions with leukocyte endothelial cell systems an experimental setup has been developed in which adhesion of small cell lung carcinoma adhesive properties can be analyzed under physiological shear stress conditions during their attachment to E- and P-selection.

AB - Hematogenous metastasis is still a poorly understood phenomenon. The rate-limiting step within the metastatic cascade is not yet clear although it may be estimated that the extravasation of circulating tumor cells is a step of crucial importance, as most tumor cells that are shed into circulation undergo apoptosis. The process of extravasation includes a cascade of consecutive steps, starting with adhesion of tumor cells circulating in the bloodstream to endothelial cells, mimicking leukocyte adhesion and transmigration. Endothelial cell selectin-leukocyte glycan interaction occurs when leukocytes adhere to endothelial cells under conditions of shear stress. As there are parallels between cancer cell endothelial interactions with leukocyte endothelial cell systems an experimental setup has been developed in which adhesion of small cell lung carcinoma adhesive properties can be analyzed under physiological shear stress conditions during their attachment to E- and P-selection.

KW - Animals

KW - Cattle

KW - Cell Adhesion

KW - Cell Culture Techniques

KW - Cell Line, Tumor

KW - E-Selectin

KW - Humans

KW - Lung Neoplasms

KW - P-Selectin

KW - Rheology

KW - Serum Albumin, Bovine

KW - Small Cell Lung Carcinoma

U2 - 10.1007/978-1-4614-8244-4_4

DO - 10.1007/978-1-4614-8244-4_4

M3 - SCORING: Journal article

C2 - 24092431

VL - 1070

SP - 47

EP - 56

JO - Methods Mol Biol

JF - Methods Mol Biol

SN - 1064-3745

ER -