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Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy

Standard

Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy. / Lim, Wei-Wen; Baumert, Mathias; Neo, Melissa; Kuklik, Pawel; Ganesan, Anand N; Lau, Dennis H; Tsoutsman, Tatiana; Semsarian, Christopher; Sanders, Prashanthan; Saint, David A.

in: CLIN EXP PHARMACOL P, Jahrgang 43, Nr. 1, 01.2016, S. 95-101.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lim, W-W, Baumert, M, Neo, M, Kuklik, P, Ganesan, AN, Lau, DH, Tsoutsman, T, Semsarian, C, Sanders, P & Saint, DA 2016, 'Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy', CLIN EXP PHARMACOL P, Jg. 43, Nr. 1, S. 95-101. https://doi.org/10.1111/1440-1681.12498

APA

Lim, W-W., Baumert, M., Neo, M., Kuklik, P., Ganesan, A. N., Lau, D. H., Tsoutsman, T., Semsarian, C., Sanders, P., & Saint, D. A. (2016). Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy. CLIN EXP PHARMACOL P, 43(1), 95-101. https://doi.org/10.1111/1440-1681.12498

Vancouver

Lim W-W, Baumert M, Neo M, Kuklik P, Ganesan AN, Lau DH et al. Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy. CLIN EXP PHARMACOL P. 2016 Jan;43(1):95-101. https://doi.org/10.1111/1440-1681.12498

Bibtex

@article{4cdcc92e2fc049b6a2fd8cdc920443fb,
title = "Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy",
abstract = "Hypertrophic cardiomyopathy (HCM) is a common heritable cardiac disorder with diverse clinical outcomes including sudden death, heart failure, and stroke. Depressed heart rate variability (HRV), a measure of cardiac autonomic regulation, has been shown to predict mortality in patients with cardiovascular disease. Cardiac autonomic remodelling in animal models of HCM are not well characterised. This study analysed Gly203Ser cardiac troponin-I transgenic (TG) male mice previously demonstrated to develop hallmarks of HCM by age 21 weeks. 33 mice aged 30 and 50 weeks underwent continuous electrocardiogram (ECG) recording for 30 min under anaesthesia. TG mice demonstrated prolonged P-wave duration (P < 0.001) and PR intervals (P < 0.001) compared to controls. Additionally, TG mice demonstrated depressed standard deviation of RR intervals (SDRR; P < 0.01), coefficient of variation of RR intervals (CVRR; P < 0.001) and standard deviation of heart rate (SDHR; P < 0.001) compared to controls. Additionally, total power was significantly reduced in TG mice (P < 0.05). No significant age-related difference in either strain was observed in ECG or HRV parameters. Mice with HCM developed slowed atrial and atrioventricular conduction and depressed HRV. These changes were conserved with increasing age. This finding may be indicative of atrial and ventricular hypertrophy or dysfunction, and perhaps an indication of worse clinical outcome in heart failure progression in HCM patients. ",
keywords = "Animals, Cardiomyopathy, Hypertrophic/physiopathology, Disease Models, Animal, Electrocardiography, Female, Heart Atria/physiopathology, Heart Conduction System/physiopathology, Heart Rate, Heart Ventricles/physiopathology, Kinetics, Male, Mice, Mice, Inbred C57BL",
author = "Wei-Wen Lim and Mathias Baumert and Melissa Neo and Pawel Kuklik and Ganesan, {Anand N} and Lau, {Dennis H} and Tatiana Tsoutsman and Christopher Semsarian and Prashanthan Sanders and Saint, {David A}",
note = "{\textcopyright} 2015 Wiley Publishing Asia Pty Ltd.",
year = "2016",
month = jan,
doi = "10.1111/1440-1681.12498",
language = "English",
volume = "43",
pages = "95--101",
journal = "CLIN EXP PHARMACOL P",
issn = "0305-1870",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy

AU - Lim, Wei-Wen

AU - Baumert, Mathias

AU - Neo, Melissa

AU - Kuklik, Pawel

AU - Ganesan, Anand N

AU - Lau, Dennis H

AU - Tsoutsman, Tatiana

AU - Semsarian, Christopher

AU - Sanders, Prashanthan

AU - Saint, David A

N1 - © 2015 Wiley Publishing Asia Pty Ltd.

PY - 2016/1

Y1 - 2016/1

N2 - Hypertrophic cardiomyopathy (HCM) is a common heritable cardiac disorder with diverse clinical outcomes including sudden death, heart failure, and stroke. Depressed heart rate variability (HRV), a measure of cardiac autonomic regulation, has been shown to predict mortality in patients with cardiovascular disease. Cardiac autonomic remodelling in animal models of HCM are not well characterised. This study analysed Gly203Ser cardiac troponin-I transgenic (TG) male mice previously demonstrated to develop hallmarks of HCM by age 21 weeks. 33 mice aged 30 and 50 weeks underwent continuous electrocardiogram (ECG) recording for 30 min under anaesthesia. TG mice demonstrated prolonged P-wave duration (P < 0.001) and PR intervals (P < 0.001) compared to controls. Additionally, TG mice demonstrated depressed standard deviation of RR intervals (SDRR; P < 0.01), coefficient of variation of RR intervals (CVRR; P < 0.001) and standard deviation of heart rate (SDHR; P < 0.001) compared to controls. Additionally, total power was significantly reduced in TG mice (P < 0.05). No significant age-related difference in either strain was observed in ECG or HRV parameters. Mice with HCM developed slowed atrial and atrioventricular conduction and depressed HRV. These changes were conserved with increasing age. This finding may be indicative of atrial and ventricular hypertrophy or dysfunction, and perhaps an indication of worse clinical outcome in heart failure progression in HCM patients.

AB - Hypertrophic cardiomyopathy (HCM) is a common heritable cardiac disorder with diverse clinical outcomes including sudden death, heart failure, and stroke. Depressed heart rate variability (HRV), a measure of cardiac autonomic regulation, has been shown to predict mortality in patients with cardiovascular disease. Cardiac autonomic remodelling in animal models of HCM are not well characterised. This study analysed Gly203Ser cardiac troponin-I transgenic (TG) male mice previously demonstrated to develop hallmarks of HCM by age 21 weeks. 33 mice aged 30 and 50 weeks underwent continuous electrocardiogram (ECG) recording for 30 min under anaesthesia. TG mice demonstrated prolonged P-wave duration (P < 0.001) and PR intervals (P < 0.001) compared to controls. Additionally, TG mice demonstrated depressed standard deviation of RR intervals (SDRR; P < 0.01), coefficient of variation of RR intervals (CVRR; P < 0.001) and standard deviation of heart rate (SDHR; P < 0.001) compared to controls. Additionally, total power was significantly reduced in TG mice (P < 0.05). No significant age-related difference in either strain was observed in ECG or HRV parameters. Mice with HCM developed slowed atrial and atrioventricular conduction and depressed HRV. These changes were conserved with increasing age. This finding may be indicative of atrial and ventricular hypertrophy or dysfunction, and perhaps an indication of worse clinical outcome in heart failure progression in HCM patients.

KW - Animals

KW - Cardiomyopathy, Hypertrophic/physiopathology

KW - Disease Models, Animal

KW - Electrocardiography

KW - Female

KW - Heart Atria/physiopathology

KW - Heart Conduction System/physiopathology

KW - Heart Rate

KW - Heart Ventricles/physiopathology

KW - Kinetics

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

U2 - 10.1111/1440-1681.12498

DO - 10.1111/1440-1681.12498

M3 - SCORING: Journal article

C2 - 26444142

VL - 43

SP - 95

EP - 101

JO - CLIN EXP PHARMACOL P

JF - CLIN EXP PHARMACOL P

SN - 0305-1870

IS - 1

ER -