Sleep deprivation is associated with attenuated parametric valuation and control signals in the midbrain during value-based decision making.
Standard
Sleep deprivation is associated with attenuated parametric valuation and control signals in the midbrain during value-based decision making. / Menz, Mareike; Büchel, Christian; Peters, Jan.
in: J NEUROSCI, Jahrgang 32, Nr. 20, 20, 2012, S. 6937-6946.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Sleep deprivation is associated with attenuated parametric valuation and control signals in the midbrain during value-based decision making.
AU - Menz, Mareike
AU - Büchel, Christian
AU - Peters, Jan
PY - 2012
Y1 - 2012
N2 - Sleep deprivation (SD) has detrimental effects on cognition, but the affected psychological processes and underlying neural mechanisms are still essentially unclear. Here we combined functional magnetic resonance imaging and computational modeling to examine how SD alters neural representation of specific choice variables (subjective value and decision conflict) during reward-related decision making. Twenty-two human subjects underwent two functional neuroimaging sessions in counterbalanced order, once during rested wakefulness and once after 24 h of SD. Behaviorally, SD attenuated conflict-dependent slowing of response times, which was reflected in an attenuated conflict-induced decrease in drift rates in the drift diffusion model. Furthermore, SD increased overall choice stochasticity during risky choice. Model-based functional neuroimaging revealed attenuated parametric subjective value signals in the midbrain, parietal cortex, and ventromedial prefrontal cortex after SD. Conflict-related midbrain signals showed a similar downregulation. Findings are discussed with respect to changes in dopaminergic signaling associated with the sleep-deprived state.
AB - Sleep deprivation (SD) has detrimental effects on cognition, but the affected psychological processes and underlying neural mechanisms are still essentially unclear. Here we combined functional magnetic resonance imaging and computational modeling to examine how SD alters neural representation of specific choice variables (subjective value and decision conflict) during reward-related decision making. Twenty-two human subjects underwent two functional neuroimaging sessions in counterbalanced order, once during rested wakefulness and once after 24 h of SD. Behaviorally, SD attenuated conflict-dependent slowing of response times, which was reflected in an attenuated conflict-induced decrease in drift rates in the drift diffusion model. Furthermore, SD increased overall choice stochasticity during risky choice. Model-based functional neuroimaging revealed attenuated parametric subjective value signals in the midbrain, parietal cortex, and ventromedial prefrontal cortex after SD. Conflict-related midbrain signals showed a similar downregulation. Findings are discussed with respect to changes in dopaminergic signaling associated with the sleep-deprived state.
KW - Adult
KW - Humans
KW - Male
KW - Models, Psychological
KW - Psychomotor Performance/physiology
KW - Parietal Lobe/physiopathology
KW - Reaction Time/physiology
KW - Decision Making/physiology
KW - Reward
KW - Prefrontal Cortex/physiopathology
KW - Choice Behavior/physiology
KW - Functional Neuroimaging/methods/psychology
KW - Magnetic Resonance Imaging/methods/psychology
KW - Mesencephalon/physiopathology
KW - Sleep Deprivation/physiopathology/psychology
KW - Adult
KW - Humans
KW - Male
KW - Models, Psychological
KW - Psychomotor Performance/physiology
KW - Parietal Lobe/physiopathology
KW - Reaction Time/physiology
KW - Decision Making/physiology
KW - Reward
KW - Prefrontal Cortex/physiopathology
KW - Choice Behavior/physiology
KW - Functional Neuroimaging/methods/psychology
KW - Magnetic Resonance Imaging/methods/psychology
KW - Mesencephalon/physiopathology
KW - Sleep Deprivation/physiopathology/psychology
M3 - SCORING: Journal article
VL - 32
SP - 6937
EP - 6946
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 20
M1 - 20
ER -
