Single-Trial Decoding of Visual Attention from Local Field Potentials in the Primate Lateral Prefrontal Cortex Is Frequency-Dependent
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Single-Trial Decoding of Visual Attention from Local Field Potentials in the Primate Lateral Prefrontal Cortex Is Frequency-Dependent. / Tremblay, Sébastien; Doucet, Guillaume; Pieper, Florian; Sachs, Adam; Martinez-Trujillo, Julio.
in: J NEUROSCI, Jahrgang 35, Nr. 24, 17.06.2015, S. 9038-49.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Single-Trial Decoding of Visual Attention from Local Field Potentials in the Primate Lateral Prefrontal Cortex Is Frequency-Dependent
AU - Tremblay, Sébastien
AU - Doucet, Guillaume
AU - Pieper, Florian
AU - Sachs, Adam
AU - Martinez-Trujillo, Julio
N1 - Copyright © 2015 the authors 0270-6474/15/359038-12$15.00/0.
PY - 2015/6/17
Y1 - 2015/6/17
N2 - Local field potentials (LFPs) are fluctuations of extracellular voltage that may reflect the physiological phenomena occurring within a volume of neural tissue. It is known that the allocation of spatial attention modulates the amplitude of LFPs in visual areas of primates. An issue that remains poorly investigated is whether and how attention modulates LFPs in executive brain areas, such as the lateral prefrontal cortex (LPFC), thought to be involved in the origins of attention. We addressed this issue by recording LFPs from multielectrode arrays implanted in the LPFC of two macaques. We found that the allocation of attention can be reliably decoded on a single-trial basis from ensembles of LFPs with frequencies >60 Hz. Using LFP frequencies <60 Hz, we could not decode the allocation of attention, but we could decode the location of a visual stimulus as well as the endpoint of saccades toward that stimulus. The information contained in the high-frequency LFPs was fully redundant with the information contained in the spiking activity of single neurons recorded from the same electrodes. Moreover, the decoding of attention using γ frequency LFPs was less accurate than using spikes, but it was twice more stable across time. Finally, decorrelating the LFP signals from the different electrodes increased decoding performance in the high frequencies by up to ∼14%. Our findings suggest that LFPs recorded from chronically implanted multielectrode arrays in the LPFC contain information about sensory, cognitive, and motor components of a task in a frequency-dependent manner.
AB - Local field potentials (LFPs) are fluctuations of extracellular voltage that may reflect the physiological phenomena occurring within a volume of neural tissue. It is known that the allocation of spatial attention modulates the amplitude of LFPs in visual areas of primates. An issue that remains poorly investigated is whether and how attention modulates LFPs in executive brain areas, such as the lateral prefrontal cortex (LPFC), thought to be involved in the origins of attention. We addressed this issue by recording LFPs from multielectrode arrays implanted in the LPFC of two macaques. We found that the allocation of attention can be reliably decoded on a single-trial basis from ensembles of LFPs with frequencies >60 Hz. Using LFP frequencies <60 Hz, we could not decode the allocation of attention, but we could decode the location of a visual stimulus as well as the endpoint of saccades toward that stimulus. The information contained in the high-frequency LFPs was fully redundant with the information contained in the spiking activity of single neurons recorded from the same electrodes. Moreover, the decoding of attention using γ frequency LFPs was less accurate than using spikes, but it was twice more stable across time. Finally, decorrelating the LFP signals from the different electrodes increased decoding performance in the high frequencies by up to ∼14%. Our findings suggest that LFPs recorded from chronically implanted multielectrode arrays in the LPFC contain information about sensory, cognitive, and motor components of a task in a frequency-dependent manner.
KW - Action Potentials
KW - Animals
KW - Attention
KW - Macaca fascicularis
KW - Male
KW - Photic Stimulation
KW - Prefrontal Cortex
KW - Psychomotor Performance
KW - Time Factors
U2 - 10.1523/JNEUROSCI.1041-15.2015
DO - 10.1523/JNEUROSCI.1041-15.2015
M3 - SCORING: Journal article
C2 - 26085629
VL - 35
SP - 9038
EP - 9049
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 24
ER -