Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents

Standard

Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents. / Wei, He; Wiśniowska, Agata; Fan, Jingxuan; Harvey, Peter; Li, Yuanyuan; Wu, Victoria; Hansen, Eric C; Zhang, Juanye; Kaul, Michael G; Frey, Abigail M; Adam, Gerhard; Frenkel, Anatoly I; Bawendi, Moungi G; Jasanoff, Alan.

in: P NATL ACAD SCI USA, Jahrgang 118, Nr. 42, e2102340118, 19.10.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

Harvard

Wei, H, Wiśniowska, A, Fan, J, Harvey, P, Li, Y, Wu, V, Hansen, EC, Zhang, J, Kaul, MG, Frey, AM, Adam, G, Frenkel, AI, Bawendi, MG & Jasanoff, A 2021, 'Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents', P NATL ACAD SCI USA, Jg. 118, Nr. 42, e2102340118. https://doi.org/10.1073/pnas.2102340118

APA

Wei, H., Wiśniowska, A., Fan, J., Harvey, P., Li, Y., Wu, V., Hansen, E. C., Zhang, J., Kaul, M. G., Frey, A. M., Adam, G., Frenkel, A. I., Bawendi, M. G., & Jasanoff, A. (2021). Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents. P NATL ACAD SCI USA, 118(42), [e2102340118]. https://doi.org/10.1073/pnas.2102340118

Vancouver

Wei H, Wiśniowska A, Fan J, Harvey P, Li Y, Wu V et al. Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents. P NATL ACAD SCI USA. 2021 Okt 19;118(42). e2102340118. https://doi.org/10.1073/pnas.2102340118

Bibtex

@article{53c98b037a004054bbb36894b057335e,
title = "Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents",
abstract = "Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide (SNIO) particles that exhibit superparamagnetic properties in conjunction with hydrodynamic diameters comparable to small, highly diffusible imaging agents. These particles efficiently brighten the signal in T 1-weighted MRI, producing per-molecule longitudinal relaxation enhancements over 10 times greater than conventional gadolinium-based contrast agents. We show that SNIOs permeate biological tissue effectively following injection into brain parenchyma or cerebrospinal fluid. We also demonstrate that SNIOs readily enter the brain following ultrasound-induced blood-brain barrier disruption, emulating the performance of a gadolinium agent and providing a basis for future biomedical applications. These results thus demonstrate a platform for MRI probe development that combines advantages of small-molecule imaging agents with the potency of nanoscale materials.",
keywords = "Animals, Blood-Brain Barrier, Contrast Media/administration & dosage, Magnetic Iron Oxide Nanoparticles/administration & dosage, Magnetic Resonance Imaging/methods, Particle Size, Permeability, Rats",
author = "He Wei and Agata Wi{\'s}niowska and Jingxuan Fan and Peter Harvey and Yuanyuan Li and Victoria Wu and Hansen, {Eric C} and Juanye Zhang and Kaul, {Michael G} and Frey, {Abigail M} and Gerhard Adam and Frenkel, {Anatoly I} and Bawendi, {Moungi G} and Alan Jasanoff",
year = "2021",
month = oct,
day = "19",
doi = "10.1073/pnas.2102340118",
language = "English",
volume = "118",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "42",

}

RIS

TY - JOUR

T1 - Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents

AU - Wei, He

AU - Wiśniowska, Agata

AU - Fan, Jingxuan

AU - Harvey, Peter

AU - Li, Yuanyuan

AU - Wu, Victoria

AU - Hansen, Eric C

AU - Zhang, Juanye

AU - Kaul, Michael G

AU - Frey, Abigail M

AU - Adam, Gerhard

AU - Frenkel, Anatoly I

AU - Bawendi, Moungi G

AU - Jasanoff, Alan

PY - 2021/10/19

Y1 - 2021/10/19

N2 - Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide (SNIO) particles that exhibit superparamagnetic properties in conjunction with hydrodynamic diameters comparable to small, highly diffusible imaging agents. These particles efficiently brighten the signal in T 1-weighted MRI, producing per-molecule longitudinal relaxation enhancements over 10 times greater than conventional gadolinium-based contrast agents. We show that SNIOs permeate biological tissue effectively following injection into brain parenchyma or cerebrospinal fluid. We also demonstrate that SNIOs readily enter the brain following ultrasound-induced blood-brain barrier disruption, emulating the performance of a gadolinium agent and providing a basis for future biomedical applications. These results thus demonstrate a platform for MRI probe development that combines advantages of small-molecule imaging agents with the potency of nanoscale materials.

AB - Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide (SNIO) particles that exhibit superparamagnetic properties in conjunction with hydrodynamic diameters comparable to small, highly diffusible imaging agents. These particles efficiently brighten the signal in T 1-weighted MRI, producing per-molecule longitudinal relaxation enhancements over 10 times greater than conventional gadolinium-based contrast agents. We show that SNIOs permeate biological tissue effectively following injection into brain parenchyma or cerebrospinal fluid. We also demonstrate that SNIOs readily enter the brain following ultrasound-induced blood-brain barrier disruption, emulating the performance of a gadolinium agent and providing a basis for future biomedical applications. These results thus demonstrate a platform for MRI probe development that combines advantages of small-molecule imaging agents with the potency of nanoscale materials.

KW - Animals

KW - Blood-Brain Barrier

KW - Contrast Media/administration & dosage

KW - Magnetic Iron Oxide Nanoparticles/administration & dosage

KW - Magnetic Resonance Imaging/methods

KW - Particle Size

KW - Permeability

KW - Rats

U2 - 10.1073/pnas.2102340118

DO - 10.1073/pnas.2102340118

M3 - SCORING: Journal article

C2 - 34654743

VL - 118

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 42

M1 - e2102340118

ER -