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Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells

Standard

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells. / Tan, Likai; Sandrock, Inga; Odak, Ivan; Aizenbud, Yuval; Wilharm, Anneke; Barros-Martins, Joana; Tabib, Yaara; Borchers, Alina; Amado, Tiago; Gangoda, Lahiru; Herold, Marco J; Schmidt-Supprian, Marc; Kisielow, Jan; Silva-Santos, Bruno; Koenecke, Christian; Hovav, Avi-Hai; Krebs, Christian; Prinz, Immo; Ravens, Sarina.

in: CELL REP, Jahrgang 27, Nr. 12, 18.06.2019, S. 3657-3671.e4.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tan, L, Sandrock, I, Odak, I, Aizenbud, Y, Wilharm, A, Barros-Martins, J, Tabib, Y, Borchers, A, Amado, T, Gangoda, L, Herold, MJ, Schmidt-Supprian, M, Kisielow, J, Silva-Santos, B, Koenecke, C, Hovav, A-H, Krebs, C, Prinz, I & Ravens, S 2019, 'Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells', CELL REP, Jg. 27, Nr. 12, S. 3657-3671.e4. https://doi.org/10.1016/j.celrep.2019.05.064

APA

Tan, L., Sandrock, I., Odak, I., Aizenbud, Y., Wilharm, A., Barros-Martins, J., Tabib, Y., Borchers, A., Amado, T., Gangoda, L., Herold, M. J., Schmidt-Supprian, M., Kisielow, J., Silva-Santos, B., Koenecke, C., Hovav, A-H., Krebs, C., Prinz, I., & Ravens, S. (2019). Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells. CELL REP, 27(12), 3657-3671.e4. https://doi.org/10.1016/j.celrep.2019.05.064

Vancouver

Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J et al. Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells. CELL REP. 2019 Jun 18;27(12):3657-3671.e4. https://doi.org/10.1016/j.celrep.2019.05.064

Bibtex

@article{405b9eb3ee504ed085860b54a573e528,
title = "Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells",
abstract = "IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues. However, their exchange between tissues and the mechanisms of their tissue-specific adaptation remain poorly understood. Here, single-cell RNA-seq profiling identifies IL-17-producing Vγ6+ T cells as a highly homogeneous Scart1+ population in contrast to their Scart2+ IL-17-producing Vγ4+ T cell counterparts. Parabiosis demonstrates that Vγ6+ T cells are fairly tissue resident in the thymus, peripheral lymph nodes, and skin. There, Scart1+ Vγ6+ T cells display tissue-specific gene expression signatures in the skin, characterized by steady-state production of the cytokines IL-17A and amphiregulin as well as by high expression of the anti-apoptotic Bcl2a1 protein family. Together, this study demonstrates how Scart1+ Vγ6+ T cells undergo tissue-specific functional adaptation to persist as effector cells in their skin habitat.",
author = "Likai Tan and Inga Sandrock and Ivan Odak and Yuval Aizenbud and Anneke Wilharm and Joana Barros-Martins and Yaara Tabib and Alina Borchers and Tiago Amado and Lahiru Gangoda and Herold, {Marco J} and Marc Schmidt-Supprian and Jan Kisielow and Bruno Silva-Santos and Christian Koenecke and Avi-Hai Hovav and Christian Krebs and Immo Prinz and Sarina Ravens",
note = "Copyright {\textcopyright} 2019 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = jun,
day = "18",
doi = "10.1016/j.celrep.2019.05.064",
language = "English",
volume = "27",
pages = "3657--3671.e4",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells

AU - Tan, Likai

AU - Sandrock, Inga

AU - Odak, Ivan

AU - Aizenbud, Yuval

AU - Wilharm, Anneke

AU - Barros-Martins, Joana

AU - Tabib, Yaara

AU - Borchers, Alina

AU - Amado, Tiago

AU - Gangoda, Lahiru

AU - Herold, Marco J

AU - Schmidt-Supprian, Marc

AU - Kisielow, Jan

AU - Silva-Santos, Bruno

AU - Koenecke, Christian

AU - Hovav, Avi-Hai

AU - Krebs, Christian

AU - Prinz, Immo

AU - Ravens, Sarina

N1 - Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2019/6/18

Y1 - 2019/6/18

N2 - IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues. However, their exchange between tissues and the mechanisms of their tissue-specific adaptation remain poorly understood. Here, single-cell RNA-seq profiling identifies IL-17-producing Vγ6+ T cells as a highly homogeneous Scart1+ population in contrast to their Scart2+ IL-17-producing Vγ4+ T cell counterparts. Parabiosis demonstrates that Vγ6+ T cells are fairly tissue resident in the thymus, peripheral lymph nodes, and skin. There, Scart1+ Vγ6+ T cells display tissue-specific gene expression signatures in the skin, characterized by steady-state production of the cytokines IL-17A and amphiregulin as well as by high expression of the anti-apoptotic Bcl2a1 protein family. Together, this study demonstrates how Scart1+ Vγ6+ T cells undergo tissue-specific functional adaptation to persist as effector cells in their skin habitat.

AB - IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues. However, their exchange between tissues and the mechanisms of their tissue-specific adaptation remain poorly understood. Here, single-cell RNA-seq profiling identifies IL-17-producing Vγ6+ T cells as a highly homogeneous Scart1+ population in contrast to their Scart2+ IL-17-producing Vγ4+ T cell counterparts. Parabiosis demonstrates that Vγ6+ T cells are fairly tissue resident in the thymus, peripheral lymph nodes, and skin. There, Scart1+ Vγ6+ T cells display tissue-specific gene expression signatures in the skin, characterized by steady-state production of the cytokines IL-17A and amphiregulin as well as by high expression of the anti-apoptotic Bcl2a1 protein family. Together, this study demonstrates how Scart1+ Vγ6+ T cells undergo tissue-specific functional adaptation to persist as effector cells in their skin habitat.

U2 - 10.1016/j.celrep.2019.05.064

DO - 10.1016/j.celrep.2019.05.064

M3 - SCORING: Journal article

C2 - 31216482

VL - 27

SP - 3657-3671.e4

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 12

ER -