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Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism

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Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism. / Dennis, J; Truong, V; Aïssi, D; Medina-Rivera, A; Blankenberg, S; Germain, M; Lemire, M; Antounians, L; Civelek, M; Schnabel, R; Wells, P; Wilson, M D; Morange, P-E; Trégouët, D-A; Gagnon, F.

in: J THROMB HAEMOST, Jahrgang 14, Nr. 10, 10.2016, S. 1960-1970.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dennis, J, Truong, V, Aïssi, D, Medina-Rivera, A, Blankenberg, S, Germain, M, Lemire, M, Antounians, L, Civelek, M, Schnabel, R, Wells, P, Wilson, MD, Morange, P-E, Trégouët, D-A & Gagnon, F 2016, 'Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism', J THROMB HAEMOST, Jg. 14, Nr. 10, S. 1960-1970. https://doi.org/10.1111/jth.13431

APA

Dennis, J., Truong, V., Aïssi, D., Medina-Rivera, A., Blankenberg, S., Germain, M., Lemire, M., Antounians, L., Civelek, M., Schnabel, R., Wells, P., Wilson, M. D., Morange, P-E., Trégouët, D-A., & Gagnon, F. (2016). Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism. J THROMB HAEMOST, 14(10), 1960-1970. https://doi.org/10.1111/jth.13431

Vancouver

Dennis J, Truong V, Aïssi D, Medina-Rivera A, Blankenberg S, Germain M et al. Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism. J THROMB HAEMOST. 2016 Okt;14(10):1960-1970. https://doi.org/10.1111/jth.13431

Bibtex

@article{606ab6402a6a47d1a549774f03359bef,
title = "Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism",
abstract = "Essentials Tissue factor pathway inhibitor (TFPI) regulates the blood coagulation cascade. We replicated previously reported linkage of TFPI plasma levels to the chromosome 2q region. The putative causal locus, rs62187992, was associated with TFPI plasma levels and thrombosis. rs62187992 was marginally associated with TFPI expression in human aortic endothelial cells. Click to hear Ann Gil's presentation on new insights into thrombin activatable fibrinolysis inhibitor SUMMARY: Background Tissue factor pathway inhibitor (TFPI) regulates fibrin clot formation, and low TFPI plasma levels increase the risk of arterial thromboembolism and venous thromboembolism (VTE). TFPI plasma levels are also heritable, and a previous linkage scan implicated the chromosome 2q region, but no specific genes. Objectives To replicate the finding of the linkage region in an independent sample, and to identify the causal locus. Methods We first performed a linkage analysis of microsatellite markers and TFPI plasma levels in 251 individuals from the F5L Family Study, and replicated the finding of the linkage peak on chromosome 2q (LOD = 3.06). We next defined a follow-up region that included 112 603 single nucleotide polymorphisms (SNPs) under the linkage peak, and meta-analyzed associations between these SNPs and TFPI plasma levels across the F5L Family Study and the Marseille Thrombosis Association (MARTHA) Study, a study of 1033 unrelated VTE patients. SNPs with false discovery rate q-values of < 0.10 were tested for association with TFPI plasma levels in 892 patients with coronary artery disease in the AtheroGene Study. Results and Conclusions One SNP, rs62187992, was associated with TFPI plasma levels in all three samples (β = + 0.14 and P = 4.23 × 10-6 combined; β = + 0.16 and P = 0.02 in the F5L Family Study; β = + 0.13 and P = 6.3 × 10-4 in the MARTHA Study; β = + 0.17 and P = 0.03 in the AtheroGene Study), and contributed to the linkage peak in the F5L Family Study. rs62187992 was also associated with clinical VTE (odds ratio 0.90, P = 0.03) in the INVENT Consortium of > 7000 cases and their controls, and was marginally associated with TFPI expression (β = + 0.19, P = 0.08) in human aortic endothelial cells, a primary site of TFPI synthesis. The biological mechanisms underlying these associations remain to be elucidated.",
keywords = "Adolescent, Adult, Aged, Aorta/pathology, Blood Coagulation, Child, Chromosome Mapping, Chromosomes, Human, Pair 2/genetics, Coronary Artery Disease/blood, Endothelial Cells/cytology, Factor V/genetics, False Positive Reactions, Female, Genetic Linkage, Homozygote, Humans, Lipoproteins/blood, Lod Score, Male, Microsatellite Repeats, Middle Aged, Pedigree, Polymorphism, Single Nucleotide, Risk Factors, Thrombosis/blood, Venous Thromboembolism/blood",
author = "J Dennis and V Truong and D A{\"i}ssi and A Medina-Rivera and S Blankenberg and M Germain and M Lemire and L Antounians and M Civelek and R Schnabel and P Wells and Wilson, {M D} and P-E Morange and D-A Tr{\'e}gou{\"e}t and F Gagnon",
note = "{\textcopyright} 2016 International Society on Thrombosis and Haemostasis.",
year = "2016",
month = oct,
doi = "10.1111/jth.13431",
language = "English",
volume = "14",
pages = "1960--1970",
journal = "J THROMB HAEMOST",
issn = "1538-7933",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism

AU - Dennis, J

AU - Truong, V

AU - Aïssi, D

AU - Medina-Rivera, A

AU - Blankenberg, S

AU - Germain, M

AU - Lemire, M

AU - Antounians, L

AU - Civelek, M

AU - Schnabel, R

AU - Wells, P

AU - Wilson, M D

AU - Morange, P-E

AU - Trégouët, D-A

AU - Gagnon, F

N1 - © 2016 International Society on Thrombosis and Haemostasis.

PY - 2016/10

Y1 - 2016/10

N2 - Essentials Tissue factor pathway inhibitor (TFPI) regulates the blood coagulation cascade. We replicated previously reported linkage of TFPI plasma levels to the chromosome 2q region. The putative causal locus, rs62187992, was associated with TFPI plasma levels and thrombosis. rs62187992 was marginally associated with TFPI expression in human aortic endothelial cells. Click to hear Ann Gil's presentation on new insights into thrombin activatable fibrinolysis inhibitor SUMMARY: Background Tissue factor pathway inhibitor (TFPI) regulates fibrin clot formation, and low TFPI plasma levels increase the risk of arterial thromboembolism and venous thromboembolism (VTE). TFPI plasma levels are also heritable, and a previous linkage scan implicated the chromosome 2q region, but no specific genes. Objectives To replicate the finding of the linkage region in an independent sample, and to identify the causal locus. Methods We first performed a linkage analysis of microsatellite markers and TFPI plasma levels in 251 individuals from the F5L Family Study, and replicated the finding of the linkage peak on chromosome 2q (LOD = 3.06). We next defined a follow-up region that included 112 603 single nucleotide polymorphisms (SNPs) under the linkage peak, and meta-analyzed associations between these SNPs and TFPI plasma levels across the F5L Family Study and the Marseille Thrombosis Association (MARTHA) Study, a study of 1033 unrelated VTE patients. SNPs with false discovery rate q-values of < 0.10 were tested for association with TFPI plasma levels in 892 patients with coronary artery disease in the AtheroGene Study. Results and Conclusions One SNP, rs62187992, was associated with TFPI plasma levels in all three samples (β = + 0.14 and P = 4.23 × 10-6 combined; β = + 0.16 and P = 0.02 in the F5L Family Study; β = + 0.13 and P = 6.3 × 10-4 in the MARTHA Study; β = + 0.17 and P = 0.03 in the AtheroGene Study), and contributed to the linkage peak in the F5L Family Study. rs62187992 was also associated with clinical VTE (odds ratio 0.90, P = 0.03) in the INVENT Consortium of > 7000 cases and their controls, and was marginally associated with TFPI expression (β = + 0.19, P = 0.08) in human aortic endothelial cells, a primary site of TFPI synthesis. The biological mechanisms underlying these associations remain to be elucidated.

AB - Essentials Tissue factor pathway inhibitor (TFPI) regulates the blood coagulation cascade. We replicated previously reported linkage of TFPI plasma levels to the chromosome 2q region. The putative causal locus, rs62187992, was associated with TFPI plasma levels and thrombosis. rs62187992 was marginally associated with TFPI expression in human aortic endothelial cells. Click to hear Ann Gil's presentation on new insights into thrombin activatable fibrinolysis inhibitor SUMMARY: Background Tissue factor pathway inhibitor (TFPI) regulates fibrin clot formation, and low TFPI plasma levels increase the risk of arterial thromboembolism and venous thromboembolism (VTE). TFPI plasma levels are also heritable, and a previous linkage scan implicated the chromosome 2q region, but no specific genes. Objectives To replicate the finding of the linkage region in an independent sample, and to identify the causal locus. Methods We first performed a linkage analysis of microsatellite markers and TFPI plasma levels in 251 individuals from the F5L Family Study, and replicated the finding of the linkage peak on chromosome 2q (LOD = 3.06). We next defined a follow-up region that included 112 603 single nucleotide polymorphisms (SNPs) under the linkage peak, and meta-analyzed associations between these SNPs and TFPI plasma levels across the F5L Family Study and the Marseille Thrombosis Association (MARTHA) Study, a study of 1033 unrelated VTE patients. SNPs with false discovery rate q-values of < 0.10 were tested for association with TFPI plasma levels in 892 patients with coronary artery disease in the AtheroGene Study. Results and Conclusions One SNP, rs62187992, was associated with TFPI plasma levels in all three samples (β = + 0.14 and P = 4.23 × 10-6 combined; β = + 0.16 and P = 0.02 in the F5L Family Study; β = + 0.13 and P = 6.3 × 10-4 in the MARTHA Study; β = + 0.17 and P = 0.03 in the AtheroGene Study), and contributed to the linkage peak in the F5L Family Study. rs62187992 was also associated with clinical VTE (odds ratio 0.90, P = 0.03) in the INVENT Consortium of > 7000 cases and their controls, and was marginally associated with TFPI expression (β = + 0.19, P = 0.08) in human aortic endothelial cells, a primary site of TFPI synthesis. The biological mechanisms underlying these associations remain to be elucidated.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aorta/pathology

KW - Blood Coagulation

KW - Child

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 2/genetics

KW - Coronary Artery Disease/blood

KW - Endothelial Cells/cytology

KW - Factor V/genetics

KW - False Positive Reactions

KW - Female

KW - Genetic Linkage

KW - Homozygote

KW - Humans

KW - Lipoproteins/blood

KW - Lod Score

KW - Male

KW - Microsatellite Repeats

KW - Middle Aged

KW - Pedigree

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Thrombosis/blood

KW - Venous Thromboembolism/blood

U2 - 10.1111/jth.13431

DO - 10.1111/jth.13431

M3 - SCORING: Journal article

C2 - 27490645

VL - 14

SP - 1960

EP - 1970

JO - J THROMB HAEMOST

JF - J THROMB HAEMOST

SN - 1538-7933

IS - 10

ER -