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Simplified Assessment of Lesion Water Uptake for Identification of Patients within 4.5 Hours of Stroke Onset: An Analysis of the MissPerfeCT Study

Standard

Simplified Assessment of Lesion Water Uptake for Identification of Patients within 4.5 Hours of Stroke Onset: An Analysis of the MissPerfeCT Study. / Sporns, Peter B; Höhne, Marco; Meyer, Lennart; Krogias, Christos; Puetz, Volker; Thierfelder, Kolja M; Duering, Marco; Kaiser, Daniel; Langner, Sönke; Brehm, Alex; Rotkopf, Lukas T; Kunz, Wolfgang G; Fiehler, Jens; Heindel, Walter; Schramm, Peter; Wiendl, Heinz; Minnerup, Heike; Psychogios, Marios Nikos; Kemmling, André; Minnerup, Jens.

in: J STROKE, Jahrgang 24, Nr. 3, 09.2022, S. 390-395.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sporns, PB, Höhne, M, Meyer, L, Krogias, C, Puetz, V, Thierfelder, KM, Duering, M, Kaiser, D, Langner, S, Brehm, A, Rotkopf, LT, Kunz, WG, Fiehler, J, Heindel, W, Schramm, P, Wiendl, H, Minnerup, H, Psychogios, MN, Kemmling, A & Minnerup, J 2022, 'Simplified Assessment of Lesion Water Uptake for Identification of Patients within 4.5 Hours of Stroke Onset: An Analysis of the MissPerfeCT Study', J STROKE, Jg. 24, Nr. 3, S. 390-395. https://doi.org/10.5853/jos.2022.00220

APA

Sporns, P. B., Höhne, M., Meyer, L., Krogias, C., Puetz, V., Thierfelder, K. M., Duering, M., Kaiser, D., Langner, S., Brehm, A., Rotkopf, L. T., Kunz, W. G., Fiehler, J., Heindel, W., Schramm, P., Wiendl, H., Minnerup, H., Psychogios, M. N., Kemmling, A., & Minnerup, J. (2022). Simplified Assessment of Lesion Water Uptake for Identification of Patients within 4.5 Hours of Stroke Onset: An Analysis of the MissPerfeCT Study. J STROKE, 24(3), 390-395. https://doi.org/10.5853/jos.2022.00220

Vancouver

Sporns PB, Höhne M, Meyer L, Krogias C, Puetz V, Thierfelder KM et al. Simplified Assessment of Lesion Water Uptake for Identification of Patients within 4.5 Hours of Stroke Onset: An Analysis of the MissPerfeCT Study. J STROKE. 2022 Sep;24(3):390-395. https://doi.org/10.5853/jos.2022.00220

Bibtex

@article{896301f61c5b43e7aa607c6999275cad,
title = "Simplified Assessment of Lesion Water Uptake for Identification of Patients within 4.5 Hours of Stroke Onset: An Analysis of the MissPerfeCT Study",
abstract = "BACKGROUND AND PURPOSE: Many patients with stroke cannot receive intravenous thrombolysis because the time of symptom onset is unknown. We tested whether a simple method of computed tomography (CT)-based quantification of water uptake in the ischemic tissue can identify patients with stroke onset within 4.5 hours.METHODS: This retrospective analysis of the MissPerfeCT study (August 2009 to November 2017) includes consecutive patients with known onset of symptoms from seven tertiary stroke centers. We developed a simplified algorithm based on region of interest (ROI) measurements to quantify water uptake of the ischemic lesion and thereby quantify time of symptom onset within and beyond 4.5 hours. Perfusion CT was used to identify ischemic brain tissue, and its density was measured in non-contrast CT and related to the density of the corresponding area of the contralateral hemisphere to quantify lesion water uptake.RESULTS: Of 263 patients, 204 (77.6%) had CT within 4.5 hours. Water uptake was significantly lower in patients with stroke onset within (6.7%; 95% confidence interval [CI], 6.0% to 7.4%) compared to beyond 4.5 hours (12.7%; 95% CI, 10.7% to 14.7%). The area under the curve for distinguishing these patient groups according to percentage water uptake was 0.744 with an optimal cut-off value of 9.5%. According to this cut-off the positive predictive value was 88.8%, sensitivity was 73.5%, specificity 67.8%, negative predictive value was 42.6%.CONCLUSIONS: Ischemic stroke patients with unknown time of symptom onset can be identified as being within a timeframe of 4.5 hours using a ROI-based method to assess water uptake on admission non-contrast head CT.",
author = "Sporns, {Peter B} and Marco H{\"o}hne and Lennart Meyer and Christos Krogias and Volker Puetz and Thierfelder, {Kolja M} and Marco Duering and Daniel Kaiser and S{\"o}nke Langner and Alex Brehm and Rotkopf, {Lukas T} and Kunz, {Wolfgang G} and Jens Fiehler and Walter Heindel and Peter Schramm and Heinz Wiendl and Heike Minnerup and Psychogios, {Marios Nikos} and Andr{\'e} Kemmling and Jens Minnerup",
year = "2022",
month = sep,
doi = "10.5853/jos.2022.00220",
language = "English",
volume = "24",
pages = "390--395",
journal = "J STROKE",
issn = "2287-6391",
publisher = "Korean Stroke Society",
number = "3",

}

RIS

TY - JOUR

T1 - Simplified Assessment of Lesion Water Uptake for Identification of Patients within 4.5 Hours of Stroke Onset: An Analysis of the MissPerfeCT Study

AU - Sporns, Peter B

AU - Höhne, Marco

AU - Meyer, Lennart

AU - Krogias, Christos

AU - Puetz, Volker

AU - Thierfelder, Kolja M

AU - Duering, Marco

AU - Kaiser, Daniel

AU - Langner, Sönke

AU - Brehm, Alex

AU - Rotkopf, Lukas T

AU - Kunz, Wolfgang G

AU - Fiehler, Jens

AU - Heindel, Walter

AU - Schramm, Peter

AU - Wiendl, Heinz

AU - Minnerup, Heike

AU - Psychogios, Marios Nikos

AU - Kemmling, André

AU - Minnerup, Jens

PY - 2022/9

Y1 - 2022/9

N2 - BACKGROUND AND PURPOSE: Many patients with stroke cannot receive intravenous thrombolysis because the time of symptom onset is unknown. We tested whether a simple method of computed tomography (CT)-based quantification of water uptake in the ischemic tissue can identify patients with stroke onset within 4.5 hours.METHODS: This retrospective analysis of the MissPerfeCT study (August 2009 to November 2017) includes consecutive patients with known onset of symptoms from seven tertiary stroke centers. We developed a simplified algorithm based on region of interest (ROI) measurements to quantify water uptake of the ischemic lesion and thereby quantify time of symptom onset within and beyond 4.5 hours. Perfusion CT was used to identify ischemic brain tissue, and its density was measured in non-contrast CT and related to the density of the corresponding area of the contralateral hemisphere to quantify lesion water uptake.RESULTS: Of 263 patients, 204 (77.6%) had CT within 4.5 hours. Water uptake was significantly lower in patients with stroke onset within (6.7%; 95% confidence interval [CI], 6.0% to 7.4%) compared to beyond 4.5 hours (12.7%; 95% CI, 10.7% to 14.7%). The area under the curve for distinguishing these patient groups according to percentage water uptake was 0.744 with an optimal cut-off value of 9.5%. According to this cut-off the positive predictive value was 88.8%, sensitivity was 73.5%, specificity 67.8%, negative predictive value was 42.6%.CONCLUSIONS: Ischemic stroke patients with unknown time of symptom onset can be identified as being within a timeframe of 4.5 hours using a ROI-based method to assess water uptake on admission non-contrast head CT.

AB - BACKGROUND AND PURPOSE: Many patients with stroke cannot receive intravenous thrombolysis because the time of symptom onset is unknown. We tested whether a simple method of computed tomography (CT)-based quantification of water uptake in the ischemic tissue can identify patients with stroke onset within 4.5 hours.METHODS: This retrospective analysis of the MissPerfeCT study (August 2009 to November 2017) includes consecutive patients with known onset of symptoms from seven tertiary stroke centers. We developed a simplified algorithm based on region of interest (ROI) measurements to quantify water uptake of the ischemic lesion and thereby quantify time of symptom onset within and beyond 4.5 hours. Perfusion CT was used to identify ischemic brain tissue, and its density was measured in non-contrast CT and related to the density of the corresponding area of the contralateral hemisphere to quantify lesion water uptake.RESULTS: Of 263 patients, 204 (77.6%) had CT within 4.5 hours. Water uptake was significantly lower in patients with stroke onset within (6.7%; 95% confidence interval [CI], 6.0% to 7.4%) compared to beyond 4.5 hours (12.7%; 95% CI, 10.7% to 14.7%). The area under the curve for distinguishing these patient groups according to percentage water uptake was 0.744 with an optimal cut-off value of 9.5%. According to this cut-off the positive predictive value was 88.8%, sensitivity was 73.5%, specificity 67.8%, negative predictive value was 42.6%.CONCLUSIONS: Ischemic stroke patients with unknown time of symptom onset can be identified as being within a timeframe of 4.5 hours using a ROI-based method to assess water uptake on admission non-contrast head CT.

U2 - 10.5853/jos.2022.00220

DO - 10.5853/jos.2022.00220

M3 - SCORING: Journal article

C2 - 36221942

VL - 24

SP - 390

EP - 395

JO - J STROKE

JF - J STROKE

SN - 2287-6391

IS - 3

ER -