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Similar patterns of loss of heterozygosity in serum of adenocarcinoma of the distal oesophagus and the cardia in early diagnosis.

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Similar patterns of loss of heterozygosity in serum of adenocarcinoma of the distal oesophagus and the cardia in early diagnosis. / Wachowiak, Robin; Kaifi, Jussuf; Schurr, Paulus; Merkert, Petra; Yekebas, Emre F.; Schwarzenbach, Heidi; Strate, Tim; Sauter, Guido; Izbicki, Jakob R.

in: ANTICANCER RES, Jahrgang 27, Nr. 1, 1, 2007, S. 477-481.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wachowiak, R, Kaifi, J, Schurr, P, Merkert, P, Yekebas, EF, Schwarzenbach, H, Strate, T, Sauter, G & Izbicki, JR 2007, 'Similar patterns of loss of heterozygosity in serum of adenocarcinoma of the distal oesophagus and the cardia in early diagnosis.', ANTICANCER RES, Jg. 27, Nr. 1, 1, S. 477-481. <http://www.ncbi.nlm.nih.gov/pubmed/17352270?dopt=Citation>

APA

Wachowiak, R., Kaifi, J., Schurr, P., Merkert, P., Yekebas, E. F., Schwarzenbach, H., Strate, T., Sauter, G., & Izbicki, J. R. (2007). Similar patterns of loss of heterozygosity in serum of adenocarcinoma of the distal oesophagus and the cardia in early diagnosis. ANTICANCER RES, 27(1), 477-481. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17352270?dopt=Citation

Vancouver

Wachowiak R, Kaifi J, Schurr P, Merkert P, Yekebas EF, Schwarzenbach H et al. Similar patterns of loss of heterozygosity in serum of adenocarcinoma of the distal oesophagus and the cardia in early diagnosis. ANTICANCER RES. 2007;27(1):477-481. 1.

Bibtex

@article{564f035076534113b6a70fd5c43a816d,
title = "Similar patterns of loss of heterozygosity in serum of adenocarcinoma of the distal oesophagus and the cardia in early diagnosis.",
abstract = "BACKGROUND: Loss of heterozygosity (LOH) may be a valuable tool for detection of malignant proceedings. The aim of our study was to investigate LOH in the serum of patients with adenocarcinoma of the distal oesophagus and the cardia for diagnostic and prognostic utility. PATIENTS AND METHODS: Matched tumour and serum samples from 46 surgically treated patients with oesophageal adenocarcinoma and cardia carcinoma divided in two groups were analysed. Twelve markers were examined with a PCR-based microsatellite analysis. RESULTS: A similar high frequency of LOH (range from 77% to 96%) was detected in the tumour and serum of both groups, whereas no LOH was detected in 20 healthy individuals. However, no significant correlation between LOH incidence and clinicopathological characteristics and survival was found. CONCLUSION: The results indicate that DNA alterations in tumours of the oesophagus and cardia are uniform. The high frequency of LOH in tumour patients underlines the utility of this molecular approach as a diagnostic tool.",
author = "Robin Wachowiak and Jussuf Kaifi and Paulus Schurr and Petra Merkert and Yekebas, {Emre F.} and Heidi Schwarzenbach and Tim Strate and Guido Sauter and Izbicki, {Jakob R.}",
year = "2007",
language = "Deutsch",
volume = "27",
pages = "477--481",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "1",

}

RIS

TY - JOUR

T1 - Similar patterns of loss of heterozygosity in serum of adenocarcinoma of the distal oesophagus and the cardia in early diagnosis.

AU - Wachowiak, Robin

AU - Kaifi, Jussuf

AU - Schurr, Paulus

AU - Merkert, Petra

AU - Yekebas, Emre F.

AU - Schwarzenbach, Heidi

AU - Strate, Tim

AU - Sauter, Guido

AU - Izbicki, Jakob R.

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Loss of heterozygosity (LOH) may be a valuable tool for detection of malignant proceedings. The aim of our study was to investigate LOH in the serum of patients with adenocarcinoma of the distal oesophagus and the cardia for diagnostic and prognostic utility. PATIENTS AND METHODS: Matched tumour and serum samples from 46 surgically treated patients with oesophageal adenocarcinoma and cardia carcinoma divided in two groups were analysed. Twelve markers were examined with a PCR-based microsatellite analysis. RESULTS: A similar high frequency of LOH (range from 77% to 96%) was detected in the tumour and serum of both groups, whereas no LOH was detected in 20 healthy individuals. However, no significant correlation between LOH incidence and clinicopathological characteristics and survival was found. CONCLUSION: The results indicate that DNA alterations in tumours of the oesophagus and cardia are uniform. The high frequency of LOH in tumour patients underlines the utility of this molecular approach as a diagnostic tool.

AB - BACKGROUND: Loss of heterozygosity (LOH) may be a valuable tool for detection of malignant proceedings. The aim of our study was to investigate LOH in the serum of patients with adenocarcinoma of the distal oesophagus and the cardia for diagnostic and prognostic utility. PATIENTS AND METHODS: Matched tumour and serum samples from 46 surgically treated patients with oesophageal adenocarcinoma and cardia carcinoma divided in two groups were analysed. Twelve markers were examined with a PCR-based microsatellite analysis. RESULTS: A similar high frequency of LOH (range from 77% to 96%) was detected in the tumour and serum of both groups, whereas no LOH was detected in 20 healthy individuals. However, no significant correlation between LOH incidence and clinicopathological characteristics and survival was found. CONCLUSION: The results indicate that DNA alterations in tumours of the oesophagus and cardia are uniform. The high frequency of LOH in tumour patients underlines the utility of this molecular approach as a diagnostic tool.

M3 - SCORING: Zeitschriftenaufsatz

VL - 27

SP - 477

EP - 481

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 1

M1 - 1

ER -