[Significance of PSMA imaging in prostate cancer]
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[Significance of PSMA imaging in prostate cancer] : Urologe A. / Gasch, C.; Duwel, C.; Kopka, K.; Kratochwil, C.; Vinsensia, M.; Eiber, M.; Maurer, T.; Haberkorn, U.; Hadaschik, B.; Giesel, F. L.
in: UROLOGE, Jahrgang 56, Nr. 1, 2017, S. 3-12.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung
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TY - JOUR
T1 - [Significance of PSMA imaging in prostate cancer]
T2 - Urologe A
AU - Gasch, C.
AU - Duwel, C.
AU - Kopka, K.
AU - Kratochwil, C.
AU - Vinsensia, M.
AU - Eiber, M.
AU - Maurer, T.
AU - Haberkorn, U.
AU - Hadaschik, B.
AU - Giesel, F. L.
N1 - 1433-0563 Gasch, C Duwel, C Kopka, K Kratochwil, C Vinsensia, M Eiber, M Maurer, T Haberkorn, U Hadaschik, B Giesel, F L Journal Article Randomized Controlled Trial Germany Urologe A. 2017 Jan;56(1):3-12. doi: 10.1007/s00120-016-0293-0.
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Prostate cancer (PCa) is one of the most common malignancies of men in developed countries. To improve clinical diagnostics of PCa, (68)Ga-PSMA-11 was recently introduced as a new PET tracer. (68)Ga-PSMA-11 is able to specifically bind to the prostate-specific membrane antigen (PSMA), which is upregulated on the surface of prostate cancer cells in most patients. OBJECTIVES: To analyse the current significance of (68)Ga-PSMA-11 PET imaging in prostate cancer in relation to staging of men with initial diagnosis, biochemical recurrence and metastatic disease. MATERIALS AND METHODS: Retrospective analysis of current literature (PubMed search) regarding (68)Ga-PSMA-11 PET diagnostics in primary staging, in biochemical recurrence and in metastasized disease. RESULTS: Compared to conventional imaging, (68)Ga-PSMA-11 PET/CT reaches a higher sensitivity with an excellent specificity in the clinical diagnosis of primary staging as well as staging for recurrence and advanced, metastasized disease. In biochemical recurrence, (68)Ga-PSMA-11 PET/CT shows significantly higher detection rates in comparison to choline PET/CT, especially in patients with low PSA values. In the clinical diagnosis of recurrent disease, therapy concepts were changed in more than a quarter of the patients due to the use of (68)Ga-PSMA-11 PET/CT. The significance of staging with (68)Ga-PSMA-11 PET/CT in advanced metastasized patients remains uncertain. CONCLUSIONS: Due to the excellent results of (68)Ga-PSMA-11 PET imaging, even in patients with slightly elevated PSA levels, it will continue to play an important role in clinical diagnostics of prostate cancer and, thus, its clinical utilization will become more widely spread.
AB - BACKGROUND: Prostate cancer (PCa) is one of the most common malignancies of men in developed countries. To improve clinical diagnostics of PCa, (68)Ga-PSMA-11 was recently introduced as a new PET tracer. (68)Ga-PSMA-11 is able to specifically bind to the prostate-specific membrane antigen (PSMA), which is upregulated on the surface of prostate cancer cells in most patients. OBJECTIVES: To analyse the current significance of (68)Ga-PSMA-11 PET imaging in prostate cancer in relation to staging of men with initial diagnosis, biochemical recurrence and metastatic disease. MATERIALS AND METHODS: Retrospective analysis of current literature (PubMed search) regarding (68)Ga-PSMA-11 PET diagnostics in primary staging, in biochemical recurrence and in metastasized disease. RESULTS: Compared to conventional imaging, (68)Ga-PSMA-11 PET/CT reaches a higher sensitivity with an excellent specificity in the clinical diagnosis of primary staging as well as staging for recurrence and advanced, metastasized disease. In biochemical recurrence, (68)Ga-PSMA-11 PET/CT shows significantly higher detection rates in comparison to choline PET/CT, especially in patients with low PSA values. In the clinical diagnosis of recurrent disease, therapy concepts were changed in more than a quarter of the patients due to the use of (68)Ga-PSMA-11 PET/CT. The significance of staging with (68)Ga-PSMA-11 PET/CT in advanced metastasized patients remains uncertain. CONCLUSIONS: Due to the excellent results of (68)Ga-PSMA-11 PET imaging, even in patients with slightly elevated PSA levels, it will continue to play an important role in clinical diagnostics of prostate cancer and, thus, its clinical utilization will become more widely spread.
KW - Edetic Acid/analogs & derivatives Evidence-Based Medicine Humans Male Oligopeptides Organometallic Compounds Prostate/diagnostic imaging/pathology Prostatic Neoplasms/diagnostic imaging/pathology Radiopharmaceuticals Reproducibility of Results Sensitivity
U2 - 10.1007/s00120-016-0293-0
DO - 10.1007/s00120-016-0293-0
M3 - SCORING: Zeitschriftenaufsatz
VL - 56
SP - 3
EP - 12
JO - UROLOGE
JF - UROLOGE
SN - 0340-2592
IS - 1
ER -
