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Should tumors be clamped in radiobiological fractionation experiments?

Standard

Should tumors be clamped in radiobiological fractionation experiments? / Beck-Bornholdt, Hans-Peter.

in: INT J RADIAT ONCOL, Jahrgang 21, Nr. 3, 3, 1991, S. 675-682.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Beck-Bornholdt, H-P 1991, 'Should tumors be clamped in radiobiological fractionation experiments?', INT J RADIAT ONCOL, Jg. 21, Nr. 3, 3, S. 675-682. <http://www.ncbi.nlm.nih.gov/pubmed/1869462?dopt=Citation>

APA

Beck-Bornholdt, H-P. (1991). Should tumors be clamped in radiobiological fractionation experiments? INT J RADIAT ONCOL, 21(3), 675-682. [3]. http://www.ncbi.nlm.nih.gov/pubmed/1869462?dopt=Citation

Vancouver

Beck-Bornholdt H-P. Should tumors be clamped in radiobiological fractionation experiments? INT J RADIAT ONCOL. 1991;21(3):675-682. 3.

Bibtex

@article{68e11e5ea9fa48b18a85b0b15c8d6446,
title = "Should tumors be clamped in radiobiological fractionation experiments?",
abstract = "In radiobiological fractionation experiments tumors are often clamped during irradiation. This is done not only to facilitate the interpretation of the data by eliminating the influence of reoxygenation but also to avoid uncontrolled changes in the hypoxic fraction that are caused by anesthesia or stress from physical restraint. In this study it is shown that clamping of tumors during irradiation also affects repair, repopulation, and redistribution. From these results it is concluded that clamping of tumors during fractionated irradiation treatment does not appear to be an adequate measure to elucidate the mechanisms that determine tumor response to radiotherapy. Even some of the fundamental concepts of tumor radiobiology might contain some uncertainties, since they are often based on data resulting from clamped tumors.",
author = "Hans-Peter Beck-Bornholdt",
year = "1991",
language = "Deutsch",
volume = "21",
pages = "675--682",
journal = "INT J RADIAT ONCOL",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Should tumors be clamped in radiobiological fractionation experiments?

AU - Beck-Bornholdt, Hans-Peter

PY - 1991

Y1 - 1991

N2 - In radiobiological fractionation experiments tumors are often clamped during irradiation. This is done not only to facilitate the interpretation of the data by eliminating the influence of reoxygenation but also to avoid uncontrolled changes in the hypoxic fraction that are caused by anesthesia or stress from physical restraint. In this study it is shown that clamping of tumors during irradiation also affects repair, repopulation, and redistribution. From these results it is concluded that clamping of tumors during fractionated irradiation treatment does not appear to be an adequate measure to elucidate the mechanisms that determine tumor response to radiotherapy. Even some of the fundamental concepts of tumor radiobiology might contain some uncertainties, since they are often based on data resulting from clamped tumors.

AB - In radiobiological fractionation experiments tumors are often clamped during irradiation. This is done not only to facilitate the interpretation of the data by eliminating the influence of reoxygenation but also to avoid uncontrolled changes in the hypoxic fraction that are caused by anesthesia or stress from physical restraint. In this study it is shown that clamping of tumors during irradiation also affects repair, repopulation, and redistribution. From these results it is concluded that clamping of tumors during fractionated irradiation treatment does not appear to be an adequate measure to elucidate the mechanisms that determine tumor response to radiotherapy. Even some of the fundamental concepts of tumor radiobiology might contain some uncertainties, since they are often based on data resulting from clamped tumors.

M3 - SCORING: Zeitschriftenaufsatz

VL - 21

SP - 675

EP - 682

JO - INT J RADIAT ONCOL

JF - INT J RADIAT ONCOL

SN - 0360-3016

IS - 3

M1 - 3

ER -