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SGK1-dependent upregulation of connective tissue growth factor by angiotensin II.

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SGK1-dependent upregulation of connective tissue growth factor by angiotensin II. / Hussain, Azeemudeen; Wyatt, Amanda W; Wang, Kan; Bhandaru, Madhuri; Biswas, Raja; Avram, Diana; Föller, Michael; Rexhepaj, Rexhep; Friedrich, Björn; Ullrich, Susanne; Müller, Gerhard; Kuhl, Dietmar; Risler, Teut; Lang, Florian.

in: KIDNEY BLOOD PRESS R, Jahrgang 31, Nr. 2, 2, 2008, S. 80-86.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hussain, A, Wyatt, AW, Wang, K, Bhandaru, M, Biswas, R, Avram, D, Föller, M, Rexhepaj, R, Friedrich, B, Ullrich, S, Müller, G, Kuhl, D, Risler, T & Lang, F 2008, 'SGK1-dependent upregulation of connective tissue growth factor by angiotensin II.', KIDNEY BLOOD PRESS R, Jg. 31, Nr. 2, 2, S. 80-86. https://doi.org/10.1159/000119703

APA

Hussain, A., Wyatt, A. W., Wang, K., Bhandaru, M., Biswas, R., Avram, D., Föller, M., Rexhepaj, R., Friedrich, B., Ullrich, S., Müller, G., Kuhl, D., Risler, T., & Lang, F. (2008). SGK1-dependent upregulation of connective tissue growth factor by angiotensin II. KIDNEY BLOOD PRESS R, 31(2), 80-86. [2]. https://doi.org/10.1159/000119703

Vancouver

Hussain A, Wyatt AW, Wang K, Bhandaru M, Biswas R, Avram D et al. SGK1-dependent upregulation of connective tissue growth factor by angiotensin II. KIDNEY BLOOD PRESS R. 2008;31(2):80-86. 2. https://doi.org/10.1159/000119703

Bibtex

@article{6f761205164b4f03938099a4bb010275,
title = "SGK1-dependent upregulation of connective tissue growth factor by angiotensin II.",
abstract = "Angiotensin II has previously been shown to trigger fibrosis, an effect involving connective tissue growth factor (CTGF). The signaling pathways linking angiotensin II to CTGF formation are, however, incompletely understood. A gene highly expressed in fibrosing tissue is the serum- and glucocorticoid-inducible kinase SGK1. The present study explored whether SGK1 is transcriptionally regulated by angiotensin II and participates in the angiotensin II-dependent regulation of CTGF expression. To this end, experiments have been performed in human kidney fibroblasts and mouse lung fibroblasts from gene-targeted mice lacking SGK1 (sgk1-/-) and their wild-type littermates (sgk1+/+). In human renal fibroblasts, SGK1 and CTGF protein expression were enhanced by angiotensin II (10 nM) within 4 h. In sgk1+/+ mouse fibroblasts, SGK1 transcript levels were significantly increased after 4 h of angiotensin II treatment. Angiotensin II stimulated both transcript and protein abundance of CTGF in fibroblasts from sgk1+/+ mice, effects significantly blunted in fibroblasts of sgk1-/- mice. In conclusion, angiotensin II stimulates the expression of SGK1, which is in turn required for the stimulating effect of angiotensin II on the expression of CTGF. Thus, SGK1 presumably contributes to the profibrotic effect of angiotensin II.",
author = "Azeemudeen Hussain and Wyatt, {Amanda W} and Kan Wang and Madhuri Bhandaru and Raja Biswas and Diana Avram and Michael F{\"o}ller and Rexhep Rexhepaj and Bj{\"o}rn Friedrich and Susanne Ullrich and Gerhard M{\"u}ller and Dietmar Kuhl and Teut Risler and Florian Lang",
year = "2008",
doi = "10.1159/000119703",
language = "Deutsch",
volume = "31",
pages = "80--86",
journal = "KIDNEY BLOOD PRESS R",
issn = "1420-4096",
publisher = "S. Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - SGK1-dependent upregulation of connective tissue growth factor by angiotensin II.

AU - Hussain, Azeemudeen

AU - Wyatt, Amanda W

AU - Wang, Kan

AU - Bhandaru, Madhuri

AU - Biswas, Raja

AU - Avram, Diana

AU - Föller, Michael

AU - Rexhepaj, Rexhep

AU - Friedrich, Björn

AU - Ullrich, Susanne

AU - Müller, Gerhard

AU - Kuhl, Dietmar

AU - Risler, Teut

AU - Lang, Florian

PY - 2008

Y1 - 2008

N2 - Angiotensin II has previously been shown to trigger fibrosis, an effect involving connective tissue growth factor (CTGF). The signaling pathways linking angiotensin II to CTGF formation are, however, incompletely understood. A gene highly expressed in fibrosing tissue is the serum- and glucocorticoid-inducible kinase SGK1. The present study explored whether SGK1 is transcriptionally regulated by angiotensin II and participates in the angiotensin II-dependent regulation of CTGF expression. To this end, experiments have been performed in human kidney fibroblasts and mouse lung fibroblasts from gene-targeted mice lacking SGK1 (sgk1-/-) and their wild-type littermates (sgk1+/+). In human renal fibroblasts, SGK1 and CTGF protein expression were enhanced by angiotensin II (10 nM) within 4 h. In sgk1+/+ mouse fibroblasts, SGK1 transcript levels were significantly increased after 4 h of angiotensin II treatment. Angiotensin II stimulated both transcript and protein abundance of CTGF in fibroblasts from sgk1+/+ mice, effects significantly blunted in fibroblasts of sgk1-/- mice. In conclusion, angiotensin II stimulates the expression of SGK1, which is in turn required for the stimulating effect of angiotensin II on the expression of CTGF. Thus, SGK1 presumably contributes to the profibrotic effect of angiotensin II.

AB - Angiotensin II has previously been shown to trigger fibrosis, an effect involving connective tissue growth factor (CTGF). The signaling pathways linking angiotensin II to CTGF formation are, however, incompletely understood. A gene highly expressed in fibrosing tissue is the serum- and glucocorticoid-inducible kinase SGK1. The present study explored whether SGK1 is transcriptionally regulated by angiotensin II and participates in the angiotensin II-dependent regulation of CTGF expression. To this end, experiments have been performed in human kidney fibroblasts and mouse lung fibroblasts from gene-targeted mice lacking SGK1 (sgk1-/-) and their wild-type littermates (sgk1+/+). In human renal fibroblasts, SGK1 and CTGF protein expression were enhanced by angiotensin II (10 nM) within 4 h. In sgk1+/+ mouse fibroblasts, SGK1 transcript levels were significantly increased after 4 h of angiotensin II treatment. Angiotensin II stimulated both transcript and protein abundance of CTGF in fibroblasts from sgk1+/+ mice, effects significantly blunted in fibroblasts of sgk1-/- mice. In conclusion, angiotensin II stimulates the expression of SGK1, which is in turn required for the stimulating effect of angiotensin II on the expression of CTGF. Thus, SGK1 presumably contributes to the profibrotic effect of angiotensin II.

U2 - 10.1159/000119703

DO - 10.1159/000119703

M3 - SCORING: Zeitschriftenaufsatz

VL - 31

SP - 80

EP - 86

JO - KIDNEY BLOOD PRESS R

JF - KIDNEY BLOOD PRESS R

SN - 1420-4096

IS - 2

M1 - 2

ER -