Sex-based differences in HIV type 1 pathogenesis

Marylyn Martina Addo; Marcus Altfeld

doi:10.1093/infdis/jiu175

Sex-based differences in HIV type 1 pathogenesis

Standard

Sex-based differences in HIV type 1 pathogenesis. / Addo, Marylyn Martina; Altfeld, Marcus.

in: J INFECT DIS, Jahrgang 209 Suppl 3, Nr. Suppl 3, 15.07.2014, S. S86-92.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Addo, MM & Altfeld, M 2014, 'Sex-based differences in HIV type 1 pathogenesis', J INFECT DIS, Jg. 209 Suppl 3, Nr. Suppl 3, S. S86-92. https://doi.org/10.1093/infdis/jiu175

APA

Addo, M. M., & Altfeld, M. (2014). Sex-based differences in HIV type 1 pathogenesis. J INFECT DIS, 209 Suppl 3(Suppl 3), S86-92. https://doi.org/10.1093/infdis/jiu175

Vancouver

Addo MM, Altfeld M. Sex-based differences in HIV type 1 pathogenesis. J INFECT DIS. 2014 Jul 15;209 Suppl 3(Suppl 3):S86-92. https://doi.org/10.1093/infdis/jiu175

Bibtex

@article{6e55621e8d7b4b929d31441ac2e04efd,

title = "Sex-based differences in HIV type 1 pathogenesis",

abstract = "Human immunodeficiency virus (HIV) remains a global infectious diseases threat that disproportionally affects women. Beyond social and political factors, biological and genetic differences have been identified that lead to differential disease courses and outcomes in men and women. Following HIV type 1 (HIV-1) seroconversion, women have up to 40% lower HIV loads and higher CD4(+) T-cell counts than men. However, at the same level of viremia, progression to AIDS is faster in women. After adjustment for viral load, HIV-positive women also display increased levels of generalized immune activation and experience the consequences of elevated inflammatory activity more frequently than men. Part of these observations are linked to sex-based differences in innate immunity, in which the differential ability of plasmacytoid dendritic cells to produce interferon α following stimulation of Toll-like receptor 7 and upregulation of interferon-stimulated genes play a central role. Here, we review the current knowledge and remaining gaps therein regarding sex-based differences in HIV-1 pathogenesis.",

keywords = "Anti-HIV Agents, Disease Susceptibility, Female, HIV Infections, HIV-1, Humans, Male, Sex Factors",

author = "Addo, {Marylyn Martina} and Marcus Altfeld",

note = "{\textcopyright} The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.",

year = "2014",

month = jul,

day = "15",

doi = "10.1093/infdis/jiu175",

language = "English",

volume = "209 Suppl 3",

pages = "S86--92",

journal = "J INFECT DIS",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "Suppl 3",

}

RIS

TY - JOUR

T1 - Sex-based differences in HIV type 1 pathogenesis

AU - Addo, Marylyn Martina

AU - Altfeld, Marcus

PY - 2014/7/15

Y1 - 2014/7/15

N2 - Human immunodeficiency virus (HIV) remains a global infectious diseases threat that disproportionally affects women. Beyond social and political factors, biological and genetic differences have been identified that lead to differential disease courses and outcomes in men and women. Following HIV type 1 (HIV-1) seroconversion, women have up to 40% lower HIV loads and higher CD4(+) T-cell counts than men. However, at the same level of viremia, progression to AIDS is faster in women. After adjustment for viral load, HIV-positive women also display increased levels of generalized immune activation and experience the consequences of elevated inflammatory activity more frequently than men. Part of these observations are linked to sex-based differences in innate immunity, in which the differential ability of plasmacytoid dendritic cells to produce interferon α following stimulation of Toll-like receptor 7 and upregulation of interferon-stimulated genes play a central role. Here, we review the current knowledge and remaining gaps therein regarding sex-based differences in HIV-1 pathogenesis.

AB - Human immunodeficiency virus (HIV) remains a global infectious diseases threat that disproportionally affects women. Beyond social and political factors, biological and genetic differences have been identified that lead to differential disease courses and outcomes in men and women. Following HIV type 1 (HIV-1) seroconversion, women have up to 40% lower HIV loads and higher CD4(+) T-cell counts than men. However, at the same level of viremia, progression to AIDS is faster in women. After adjustment for viral load, HIV-positive women also display increased levels of generalized immune activation and experience the consequences of elevated inflammatory activity more frequently than men. Part of these observations are linked to sex-based differences in innate immunity, in which the differential ability of plasmacytoid dendritic cells to produce interferon α following stimulation of Toll-like receptor 7 and upregulation of interferon-stimulated genes play a central role. Here, we review the current knowledge and remaining gaps therein regarding sex-based differences in HIV-1 pathogenesis.

KW - Anti-HIV Agents

KW - Disease Susceptibility

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Sex Factors

U2 - 10.1093/infdis/jiu175

DO - 10.1093/infdis/jiu175

M3 - SCORING: Journal article

C2 - 24966195

VL - 209 Suppl 3

SP - S86-92

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - Suppl 3

ER -