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Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis

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Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis. / Ramien, Caren; Taenzer, Aline; Lupu, Andreea; Heckmann, Nina; Engler, Jan Broder; Patas, Konstantinos; Friese, Manuel A; Gold, Stefan M.

in: NEUROSCI BIOBEHAV R, Jahrgang 67, 08.2016, S. 137-46.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ramien, C, Taenzer, A, Lupu, A, Heckmann, N, Engler, JB, Patas, K, Friese, MA & Gold, SM 2016, 'Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis', NEUROSCI BIOBEHAV R, Jg. 67, S. 137-46. https://doi.org/10.1016/j.neubiorev.2015.12.015

APA

Ramien, C., Taenzer, A., Lupu, A., Heckmann, N., Engler, J. B., Patas, K., Friese, M. A., & Gold, S. M. (2016). Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis. NEUROSCI BIOBEHAV R, 67, 137-46. https://doi.org/10.1016/j.neubiorev.2015.12.015

Vancouver

Ramien C, Taenzer A, Lupu A, Heckmann N, Engler JB, Patas K et al. Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis. NEUROSCI BIOBEHAV R. 2016 Aug;67:137-46. https://doi.org/10.1016/j.neubiorev.2015.12.015

Bibtex

@article{962749cd3a404bc989cc570e91b977eb,
title = "Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis",
abstract = "Clinical observations in human autoimmune diseases such as multiple sclerosis (MS) suggest a pivotal role of sex-related factors in the etiopathogenesis. These include a female preponderance in MS incidence and an increasing sex bias over time, a parent-of-origin effect in MS inheritance, and the protective effect of pregnancy on disease activity. The complex interplay of factors contributing to these clinical phenomena, however, is incompletely understood and may include sex hormones as well as genetic or epigenetic sex differences. While genetic and hormonal effects are impossible to study independently in humans, novel mouse models have started to unravel the cause-effect relationship between individual sex-related factors and autoimmunity. Here, we present the evidence for mechanisms underlying sex differences in the immune system and the central nervous system (CNS) and how these might help to explain some of the clinically observed sex differences in MS. A better understanding of the molecular underpinnings may ultimately help to devise sex-specific treatment strategies as well as highlight novel avenues for therapy in both sexes.",
author = "Caren Ramien and Aline Taenzer and Andreea Lupu and Nina Heckmann and Engler, {Jan Broder} and Konstantinos Patas and Friese, {Manuel A} and Gold, {Stefan M}",
note = "Copyright {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
month = aug,
doi = "10.1016/j.neubiorev.2015.12.015",
language = "English",
volume = "67",
pages = "137--46",
journal = "NEUROSCI BIOBEHAV R",
issn = "0149-7634",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis

AU - Ramien, Caren

AU - Taenzer, Aline

AU - Lupu, Andreea

AU - Heckmann, Nina

AU - Engler, Jan Broder

AU - Patas, Konstantinos

AU - Friese, Manuel A

AU - Gold, Stefan M

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/8

Y1 - 2016/8

N2 - Clinical observations in human autoimmune diseases such as multiple sclerosis (MS) suggest a pivotal role of sex-related factors in the etiopathogenesis. These include a female preponderance in MS incidence and an increasing sex bias over time, a parent-of-origin effect in MS inheritance, and the protective effect of pregnancy on disease activity. The complex interplay of factors contributing to these clinical phenomena, however, is incompletely understood and may include sex hormones as well as genetic or epigenetic sex differences. While genetic and hormonal effects are impossible to study independently in humans, novel mouse models have started to unravel the cause-effect relationship between individual sex-related factors and autoimmunity. Here, we present the evidence for mechanisms underlying sex differences in the immune system and the central nervous system (CNS) and how these might help to explain some of the clinically observed sex differences in MS. A better understanding of the molecular underpinnings may ultimately help to devise sex-specific treatment strategies as well as highlight novel avenues for therapy in both sexes.

AB - Clinical observations in human autoimmune diseases such as multiple sclerosis (MS) suggest a pivotal role of sex-related factors in the etiopathogenesis. These include a female preponderance in MS incidence and an increasing sex bias over time, a parent-of-origin effect in MS inheritance, and the protective effect of pregnancy on disease activity. The complex interplay of factors contributing to these clinical phenomena, however, is incompletely understood and may include sex hormones as well as genetic or epigenetic sex differences. While genetic and hormonal effects are impossible to study independently in humans, novel mouse models have started to unravel the cause-effect relationship between individual sex-related factors and autoimmunity. Here, we present the evidence for mechanisms underlying sex differences in the immune system and the central nervous system (CNS) and how these might help to explain some of the clinically observed sex differences in MS. A better understanding of the molecular underpinnings may ultimately help to devise sex-specific treatment strategies as well as highlight novel avenues for therapy in both sexes.

U2 - 10.1016/j.neubiorev.2015.12.015

DO - 10.1016/j.neubiorev.2015.12.015

M3 - SCORING: Journal article

C2 - 26773723

VL - 67

SP - 137

EP - 146

JO - NEUROSCI BIOBEHAV R

JF - NEUROSCI BIOBEHAV R

SN - 0149-7634

ER -