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Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women

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Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women. / Griesbeck, Morgane; Ziegler, Susanne; Laffont, Sophie; Smith, Nikaïa; Chauveau, Lise; Tomezsko, Phillip; Sharei, Armon; Kourjian, Georgio; Porichis, Filippos; Hart, Meghan; Palmer, Christine D; Sirignano, Michael; Beisel, Claudia; Hildebrandt, Heike; Cénac, Claire; Villani, Alexandra-Chloé; Diefenbach, Thomas J; Le Gall, Sylvie; Schwartz, Olivier; Herbeuval, Jean-Philippe; Autran, Brigitte; Guéry, Jean-Charles; Chang, J Judy; Altfeld, Marcus.

in: J IMMUNOL, Jahrgang 195, Nr. 11, 01.12.2015, S. 5327-36.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Griesbeck, M, Ziegler, S, Laffont, S, Smith, N, Chauveau, L, Tomezsko, P, Sharei, A, Kourjian, G, Porichis, F, Hart, M, Palmer, CD, Sirignano, M, Beisel, C, Hildebrandt, H, Cénac, C, Villani, A-C, Diefenbach, TJ, Le Gall, S, Schwartz, O, Herbeuval, J-P, Autran, B, Guéry, J-C, Chang, JJ & Altfeld, M 2015, 'Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women', J IMMUNOL, Jg. 195, Nr. 11, S. 5327-36. https://doi.org/10.4049/jimmunol.1501684

APA

Griesbeck, M., Ziegler, S., Laffont, S., Smith, N., Chauveau, L., Tomezsko, P., Sharei, A., Kourjian, G., Porichis, F., Hart, M., Palmer, C. D., Sirignano, M., Beisel, C., Hildebrandt, H., Cénac, C., Villani, A-C., Diefenbach, T. J., Le Gall, S., Schwartz, O., ... Altfeld, M. (2015). Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women. J IMMUNOL, 195(11), 5327-36. https://doi.org/10.4049/jimmunol.1501684

Vancouver

Griesbeck M, Ziegler S, Laffont S, Smith N, Chauveau L, Tomezsko P et al. Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women. J IMMUNOL. 2015 Dez 1;195(11):5327-36. https://doi.org/10.4049/jimmunol.1501684

Bibtex

@article{a727c0ebecfb43f5a1df9064ef70f036,
title = "Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women",
abstract = "Increased IFN-α production contributes to the pathogenesis of infectious and autoimmune diseases. Plasmacytoid dendritic cells (pDCs) from females produce more IFN-α upon TLR7 stimulation than pDCs from males, yet the mechanisms underlying this difference remain unclear. In this article, we show that basal levels of IFN regulatory factor (IRF) 5 in pDCs were significantly higher in females compared with males and positively correlated with the percentage of IFN-α-secreting pDCs. Delivery of recombinant IRF5 protein into human primary pDCs increased TLR7-mediated IFN-α secretion. In mice, genetic ablation of the estrogen receptor 1 (Esr1) gene in the hematopoietic compartment or DC lineage reduced Irf5 mRNA expression in pDCs and IFN-α production. IRF5 mRNA levels furthermore correlated with ESR1 mRNA levels in human pDCs, consistent with IRF5 regulation at the transcriptional level by ESR1. Taken together, these data demonstrate a critical mechanism by which sex differences in basal pDC IRF5 expression lead to higher IFN-α production upon TLR7 stimulation in females and provide novel targets for the modulation of immune responses and inflammation.",
author = "Morgane Griesbeck and Susanne Ziegler and Sophie Laffont and Nika{\"i}a Smith and Lise Chauveau and Phillip Tomezsko and Armon Sharei and Georgio Kourjian and Filippos Porichis and Meghan Hart and Palmer, {Christine D} and Michael Sirignano and Claudia Beisel and Heike Hildebrandt and Claire C{\'e}nac and Alexandra-Chlo{\'e} Villani and Diefenbach, {Thomas J} and {Le Gall}, Sylvie and Olivier Schwartz and Jean-Philippe Herbeuval and Brigitte Autran and Jean-Charles Gu{\'e}ry and Chang, {J Judy} and Marcus Altfeld",
note = "Copyright {\textcopyright} 2015 by The American Association of Immunologists, Inc.",
year = "2015",
month = dec,
day = "1",
doi = "10.4049/jimmunol.1501684",
language = "English",
volume = "195",
pages = "5327--36",
journal = "J IMMUNOL",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "11",

}

RIS

TY - JOUR

T1 - Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women

AU - Griesbeck, Morgane

AU - Ziegler, Susanne

AU - Laffont, Sophie

AU - Smith, Nikaïa

AU - Chauveau, Lise

AU - Tomezsko, Phillip

AU - Sharei, Armon

AU - Kourjian, Georgio

AU - Porichis, Filippos

AU - Hart, Meghan

AU - Palmer, Christine D

AU - Sirignano, Michael

AU - Beisel, Claudia

AU - Hildebrandt, Heike

AU - Cénac, Claire

AU - Villani, Alexandra-Chloé

AU - Diefenbach, Thomas J

AU - Le Gall, Sylvie

AU - Schwartz, Olivier

AU - Herbeuval, Jean-Philippe

AU - Autran, Brigitte

AU - Guéry, Jean-Charles

AU - Chang, J Judy

AU - Altfeld, Marcus

N1 - Copyright © 2015 by The American Association of Immunologists, Inc.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Increased IFN-α production contributes to the pathogenesis of infectious and autoimmune diseases. Plasmacytoid dendritic cells (pDCs) from females produce more IFN-α upon TLR7 stimulation than pDCs from males, yet the mechanisms underlying this difference remain unclear. In this article, we show that basal levels of IFN regulatory factor (IRF) 5 in pDCs were significantly higher in females compared with males and positively correlated with the percentage of IFN-α-secreting pDCs. Delivery of recombinant IRF5 protein into human primary pDCs increased TLR7-mediated IFN-α secretion. In mice, genetic ablation of the estrogen receptor 1 (Esr1) gene in the hematopoietic compartment or DC lineage reduced Irf5 mRNA expression in pDCs and IFN-α production. IRF5 mRNA levels furthermore correlated with ESR1 mRNA levels in human pDCs, consistent with IRF5 regulation at the transcriptional level by ESR1. Taken together, these data demonstrate a critical mechanism by which sex differences in basal pDC IRF5 expression lead to higher IFN-α production upon TLR7 stimulation in females and provide novel targets for the modulation of immune responses and inflammation.

AB - Increased IFN-α production contributes to the pathogenesis of infectious and autoimmune diseases. Plasmacytoid dendritic cells (pDCs) from females produce more IFN-α upon TLR7 stimulation than pDCs from males, yet the mechanisms underlying this difference remain unclear. In this article, we show that basal levels of IFN regulatory factor (IRF) 5 in pDCs were significantly higher in females compared with males and positively correlated with the percentage of IFN-α-secreting pDCs. Delivery of recombinant IRF5 protein into human primary pDCs increased TLR7-mediated IFN-α secretion. In mice, genetic ablation of the estrogen receptor 1 (Esr1) gene in the hematopoietic compartment or DC lineage reduced Irf5 mRNA expression in pDCs and IFN-α production. IRF5 mRNA levels furthermore correlated with ESR1 mRNA levels in human pDCs, consistent with IRF5 regulation at the transcriptional level by ESR1. Taken together, these data demonstrate a critical mechanism by which sex differences in basal pDC IRF5 expression lead to higher IFN-α production upon TLR7 stimulation in females and provide novel targets for the modulation of immune responses and inflammation.

U2 - 10.4049/jimmunol.1501684

DO - 10.4049/jimmunol.1501684

M3 - SCORING: Journal article

C2 - 26519527

VL - 195

SP - 5327

EP - 5336

JO - J IMMUNOL

JF - J IMMUNOL

SN - 0022-1767

IS - 11

ER -