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Sex differences in HIV-1-mediated immunopathology

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Sex differences in HIV-1-mediated immunopathology. / Ziegler, Susanne; Altfeld, Marcus.

in: CURR OPIN HIV AIDS, Jahrgang 11, Nr. 2, 03.2016, S. 209-15.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Ziegler, S & Altfeld, M 2016, 'Sex differences in HIV-1-mediated immunopathology', CURR OPIN HIV AIDS, Jg. 11, Nr. 2, S. 209-15. https://doi.org/10.1097/COH.0000000000000237

APA

Ziegler, S., & Altfeld, M. (2016). Sex differences in HIV-1-mediated immunopathology. CURR OPIN HIV AIDS, 11(2), 209-15. https://doi.org/10.1097/COH.0000000000000237

Vancouver

Ziegler S, Altfeld M. Sex differences in HIV-1-mediated immunopathology. CURR OPIN HIV AIDS. 2016 Mär;11(2):209-15. https://doi.org/10.1097/COH.0000000000000237

Bibtex

@article{93956e06ccf94f478588999539311581,
title = "Sex differences in HIV-1-mediated immunopathology",
abstract = "PURPOSE OF REVIEW: The article reviews our current knowledge regarding the role of sex and sex hormones in regulating innate immune responses to viral infections, which may account for the described sex differences in immunity to HIV-1.RECENT FINDINGS: Prominent sex differences exist in various infectious and autoimmune diseases. Biological mechanisms underlying these differences include the modulation of immunological pathways by sex hormones and gene dosage effects of immunomodulatory genes encoded by the X chromosome. During HIV-1 infections, women have been shown to present with lower viral load levels in primary infection, although their progression to AIDS is faster in comparison with men when accounting for viral load levels in chronic infection. HIV-1-infected women furthermore tend to have higher levels of immune activation and interferon-stimulated gene expression in comparison with men for the same viral load, which has been associated to innate sensing of HIV-1 by Toll-like receptor 7 and the consequent interferon-α production by plasmacytoid dendritic cells.SUMMARY: Improvement in understanding the mechanisms associated with sex differences in HIV-1-mediated immunopathology will be critical to take sex differences into consideration when designing experimental and clinical studies in HIV-1-infected populations.",
keywords = "Estrogens, Female, HIV Infections/immunology, Humans, Interferon-alpha, Male, Sex Factors, Toll-Like Receptors",
author = "Susanne Ziegler and Marcus Altfeld",
year = "2016",
month = mar,
doi = "10.1097/COH.0000000000000237",
language = "English",
volume = "11",
pages = "209--15",
journal = "CURR OPIN HIV AIDS",
issn = "1746-630X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Sex differences in HIV-1-mediated immunopathology

AU - Ziegler, Susanne

AU - Altfeld, Marcus

PY - 2016/3

Y1 - 2016/3

N2 - PURPOSE OF REVIEW: The article reviews our current knowledge regarding the role of sex and sex hormones in regulating innate immune responses to viral infections, which may account for the described sex differences in immunity to HIV-1.RECENT FINDINGS: Prominent sex differences exist in various infectious and autoimmune diseases. Biological mechanisms underlying these differences include the modulation of immunological pathways by sex hormones and gene dosage effects of immunomodulatory genes encoded by the X chromosome. During HIV-1 infections, women have been shown to present with lower viral load levels in primary infection, although their progression to AIDS is faster in comparison with men when accounting for viral load levels in chronic infection. HIV-1-infected women furthermore tend to have higher levels of immune activation and interferon-stimulated gene expression in comparison with men for the same viral load, which has been associated to innate sensing of HIV-1 by Toll-like receptor 7 and the consequent interferon-α production by plasmacytoid dendritic cells.SUMMARY: Improvement in understanding the mechanisms associated with sex differences in HIV-1-mediated immunopathology will be critical to take sex differences into consideration when designing experimental and clinical studies in HIV-1-infected populations.

AB - PURPOSE OF REVIEW: The article reviews our current knowledge regarding the role of sex and sex hormones in regulating innate immune responses to viral infections, which may account for the described sex differences in immunity to HIV-1.RECENT FINDINGS: Prominent sex differences exist in various infectious and autoimmune diseases. Biological mechanisms underlying these differences include the modulation of immunological pathways by sex hormones and gene dosage effects of immunomodulatory genes encoded by the X chromosome. During HIV-1 infections, women have been shown to present with lower viral load levels in primary infection, although their progression to AIDS is faster in comparison with men when accounting for viral load levels in chronic infection. HIV-1-infected women furthermore tend to have higher levels of immune activation and interferon-stimulated gene expression in comparison with men for the same viral load, which has been associated to innate sensing of HIV-1 by Toll-like receptor 7 and the consequent interferon-α production by plasmacytoid dendritic cells.SUMMARY: Improvement in understanding the mechanisms associated with sex differences in HIV-1-mediated immunopathology will be critical to take sex differences into consideration when designing experimental and clinical studies in HIV-1-infected populations.

KW - Estrogens

KW - Female

KW - HIV Infections/immunology

KW - Humans

KW - Interferon-alpha

KW - Male

KW - Sex Factors

KW - Toll-Like Receptors

U2 - 10.1097/COH.0000000000000237

DO - 10.1097/COH.0000000000000237

M3 - SCORING: Review article

C2 - 26845674

VL - 11

SP - 209

EP - 215

JO - CURR OPIN HIV AIDS

JF - CURR OPIN HIV AIDS

SN - 1746-630X

IS - 2

ER -