Sex differences in early carotid atherosclerosis (from the community-based Gutenberg-Heart Study)
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Sex differences in early carotid atherosclerosis (from the community-based Gutenberg-Heart Study). / Sinning, Christoph; Wild, Philip S; Echevarria, Francisco M Ojeda; Wilde, Sandra; Schnabel, Renate; Lubos, Edith; Herkenhoff, Stephanie; Bickel, Christoph; Klimpe, Sven; Gori, Tommaso; Münzel, Thomas F; Blankenberg, Stefan; Espinola-Klein, Christine; Gutenberg-Heart Study.
in: AM J CARDIOL, Jahrgang 107, Nr. 12, 15.06.2011, S. 1841-1847.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Sex differences in early carotid atherosclerosis (from the community-based Gutenberg-Heart Study)
AU - Sinning, Christoph
AU - Wild, Philip S
AU - Echevarria, Francisco M Ojeda
AU - Wilde, Sandra
AU - Schnabel, Renate
AU - Lubos, Edith
AU - Herkenhoff, Stephanie
AU - Bickel, Christoph
AU - Klimpe, Sven
AU - Gori, Tommaso
AU - Münzel, Thomas F
AU - Blankenberg, Stefan
AU - Espinola-Klein, Christine
AU - Gutenberg-Heart Study
N1 - Copyright © 2011 Elsevier Inc. All rights reserved.
PY - 2011/6/15
Y1 - 2011/6/15
N2 - The objectives of this study were to describe gender differences in intima-media thickness (IMT) in a community-based population study and to define normal IMT values for healthy men and women. In total, 4,814 participants (aged 35 to 74 years; 2,433 men, 2,381 women) from the Gutenberg-Heart Study (GHS) were included. IMT was measured at both common carotid arteries using an edge detection system. Median IMT was 0.62 mm (25th percentile 0.55, 75th percentile 0.70) in women and 0.65 mm (25th percentile 0.57, 75th percentile 0.75) in men and was significantly associated with age (p <0.0001). On multivariate analysis, advanced age, smoking, and arterial hypertension were positively associated with higher IMT in men and women. A subgroup of 1,025 subjects without cardiovascular risk factors or previous cardiovascular disease was analyzed to define normal IMT values. Nomograms were calculated according to age and gender. For each age group, IMT >95th percentile was defined as abnormal. In this subgroup, gender differences in IMT became nonsignificant at older ages. At the age of 35 years, IMT was 0.71 mm in men and 0.61 mm in women at the 95th percentile. In comparison, at the age of 74 years, IMT at the 95th percentile was 0.90 mm in men and 0.89 mm in women. In conclusion, men had higher carotid IMT than women, but predictors of early carotid atherosclerosis were similar across genders. In young subjects without cardiovascular risk factors, normal values for IMT were lower in women compared with men. In contrast, in older subjects, gender differences in IMT became nonsignificant.
AB - The objectives of this study were to describe gender differences in intima-media thickness (IMT) in a community-based population study and to define normal IMT values for healthy men and women. In total, 4,814 participants (aged 35 to 74 years; 2,433 men, 2,381 women) from the Gutenberg-Heart Study (GHS) were included. IMT was measured at both common carotid arteries using an edge detection system. Median IMT was 0.62 mm (25th percentile 0.55, 75th percentile 0.70) in women and 0.65 mm (25th percentile 0.57, 75th percentile 0.75) in men and was significantly associated with age (p <0.0001). On multivariate analysis, advanced age, smoking, and arterial hypertension were positively associated with higher IMT in men and women. A subgroup of 1,025 subjects without cardiovascular risk factors or previous cardiovascular disease was analyzed to define normal IMT values. Nomograms were calculated according to age and gender. For each age group, IMT >95th percentile was defined as abnormal. In this subgroup, gender differences in IMT became nonsignificant at older ages. At the age of 35 years, IMT was 0.71 mm in men and 0.61 mm in women at the 95th percentile. In comparison, at the age of 74 years, IMT at the 95th percentile was 0.90 mm in men and 0.89 mm in women. In conclusion, men had higher carotid IMT than women, but predictors of early carotid atherosclerosis were similar across genders. In young subjects without cardiovascular risk factors, normal values for IMT were lower in women compared with men. In contrast, in older subjects, gender differences in IMT became nonsignificant.
KW - Adult
KW - Aged
KW - Carotid Artery Diseases/pathology
KW - Carotid Artery, Common/pathology
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Risk Factors
KW - Sex Characteristics
KW - Tunica Intima/pathology
KW - Tunica Media/pathology
U2 - 10.1016/j.amjcard.2011.02.318
DO - 10.1016/j.amjcard.2011.02.318
M3 - SCORING: Journal article
C2 - 21481827
VL - 107
SP - 1841
EP - 1847
JO - AM J CARDIOL
JF - AM J CARDIOL
SN - 0002-9149
IS - 12
ER -