Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia.

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Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia. / Anderssohn, Maike; Maaß, Laura; Diemert, Anke; Lüneburg, Nicole; Atzler, Dorothee; Hecher, Kurt; Böger, Rainer.

in: EUR J OBSTET GYN R B, Jahrgang 161, Nr. 2, 2, 2012, S. 152-156.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{cda3203f4f994aa5b6629d9b4bfc63e3,
title = "Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia.",
abstract = "Asymmetric dimethylarginine (ADMA) is a key regulator of nitric oxide production. Elevations of ADMA have previously been associated with endothelial dysfunction in pre-eclamptic women. ADMA is degraded mainly by dimethylarginine dimethylaminohydrolase (DDAH), which is also expressed in placental tissue. Therefore, we measured placental DDAH expression and activity in pre-eclampsia and normal pregnancies in order to determine whether impairment of this enzyme in the pre-eclamptic placenta could contribute to elevations of ADMA levels in these women.",
author = "Maike Anderssohn and Laura Maa{\ss} and Anke Diemert and Nicole L{\"u}neburg and Dorothee Atzler and Kurt Hecher and Rainer B{\"o}ger",
year = "2012",
language = "English",
volume = "161",
pages = "152--156",
journal = "EUR J OBSTET GYN R B",
issn = "0301-2115",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia.

AU - Anderssohn, Maike

AU - Maaß, Laura

AU - Diemert, Anke

AU - Lüneburg, Nicole

AU - Atzler, Dorothee

AU - Hecher, Kurt

AU - Böger, Rainer

PY - 2012

Y1 - 2012

N2 - Asymmetric dimethylarginine (ADMA) is a key regulator of nitric oxide production. Elevations of ADMA have previously been associated with endothelial dysfunction in pre-eclamptic women. ADMA is degraded mainly by dimethylarginine dimethylaminohydrolase (DDAH), which is also expressed in placental tissue. Therefore, we measured placental DDAH expression and activity in pre-eclampsia and normal pregnancies in order to determine whether impairment of this enzyme in the pre-eclamptic placenta could contribute to elevations of ADMA levels in these women.

AB - Asymmetric dimethylarginine (ADMA) is a key regulator of nitric oxide production. Elevations of ADMA have previously been associated with endothelial dysfunction in pre-eclamptic women. ADMA is degraded mainly by dimethylarginine dimethylaminohydrolase (DDAH), which is also expressed in placental tissue. Therefore, we measured placental DDAH expression and activity in pre-eclampsia and normal pregnancies in order to determine whether impairment of this enzyme in the pre-eclamptic placenta could contribute to elevations of ADMA levels in these women.

M3 - SCORING: Journal article

VL - 161

SP - 152

EP - 156

JO - EUR J OBSTET GYN R B

JF - EUR J OBSTET GYN R B

SN - 0301-2115

IS - 2

M1 - 2

ER -