Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia.
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Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia. / Anderssohn, Maike; Maaß, Laura; Diemert, Anke; Lüneburg, Nicole; Atzler, Dorothee; Hecher, Kurt; Böger, Rainer.
in: EUR J OBSTET GYN R B, Jahrgang 161, Nr. 2, 2, 2012, S. 152-156.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia.
AU - Anderssohn, Maike
AU - Maaß, Laura
AU - Diemert, Anke
AU - Lüneburg, Nicole
AU - Atzler, Dorothee
AU - Hecher, Kurt
AU - Böger, Rainer
PY - 2012
Y1 - 2012
N2 - Asymmetric dimethylarginine (ADMA) is a key regulator of nitric oxide production. Elevations of ADMA have previously been associated with endothelial dysfunction in pre-eclamptic women. ADMA is degraded mainly by dimethylarginine dimethylaminohydrolase (DDAH), which is also expressed in placental tissue. Therefore, we measured placental DDAH expression and activity in pre-eclampsia and normal pregnancies in order to determine whether impairment of this enzyme in the pre-eclamptic placenta could contribute to elevations of ADMA levels in these women.
AB - Asymmetric dimethylarginine (ADMA) is a key regulator of nitric oxide production. Elevations of ADMA have previously been associated with endothelial dysfunction in pre-eclamptic women. ADMA is degraded mainly by dimethylarginine dimethylaminohydrolase (DDAH), which is also expressed in placental tissue. Therefore, we measured placental DDAH expression and activity in pre-eclampsia and normal pregnancies in order to determine whether impairment of this enzyme in the pre-eclamptic placenta could contribute to elevations of ADMA levels in these women.
M3 - SCORING: Journal article
VL - 161
SP - 152
EP - 156
JO - EUR J OBSTET GYN R B
JF - EUR J OBSTET GYN R B
SN - 0301-2115
IS - 2
M1 - 2
ER -