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Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells

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Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells. / Lindenmeyer, Maja T; Hrenn, Andrea; Kern, Claudia; Castro, Victor; Murillo, Renato; Müller, Stefan; Laufer, Stefan; Schulte-Mönting, Jürgen; Siedle, Bettina; Merfort, Irmgard.

in: BIOORGAN MED CHEM, Jahrgang 14, Nr. 8, 15.04.2006, S. 2487-97.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lindenmeyer, MT, Hrenn, A, Kern, C, Castro, V, Murillo, R, Müller, S, Laufer, S, Schulte-Mönting, J, Siedle, B & Merfort, I 2006, 'Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells', BIOORGAN MED CHEM, Jg. 14, Nr. 8, S. 2487-97. https://doi.org/10.1016/j.bmc.2005.11.027

APA

Lindenmeyer, M. T., Hrenn, A., Kern, C., Castro, V., Murillo, R., Müller, S., Laufer, S., Schulte-Mönting, J., Siedle, B., & Merfort, I. (2006). Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells. BIOORGAN MED CHEM, 14(8), 2487-97. https://doi.org/10.1016/j.bmc.2005.11.027

Vancouver

Lindenmeyer MT, Hrenn A, Kern C, Castro V, Murillo R, Müller S et al. Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells. BIOORGAN MED CHEM. 2006 Apr 15;14(8):2487-97. https://doi.org/10.1016/j.bmc.2005.11.027

Bibtex

@article{478eb5af59504d96a3ff72309b61b3a1,
title = "Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells",
abstract = "Twenty-four structurally different SLs were studied for their inhibition on IL-8 production in HeLa229 cells and different IC50-values were obtained. QSAR analyses revealed that the alpha-methylene-gamma-lactone and the presence and reactivity of a second reaction center, expressed by LUMO2, are the most important descriptors for IL-8. Using two SLs as examples, we demonstrated that SLs prevent DNA binding of AP-1, which has binding sites in the IL-8 promoter together with NF-kappaB and C/EBP, and that this is probably due to directly targeting AP-1. p38 MAPK, which plays a role in AP-1 activation as well as in IL-8 regulation, was not influenced by SLs. These data show that NF-kappaB and AP-1, and consequently IL-8 may be interesting targets in antiinflammation research and that the small molecules of SLs may be powerful candidates with promising properties for therapeutic modulation of the inflammatory response.",
keywords = "Base Sequence, CCAAT-Enhancer-Binding Proteins, DNA Primers, Down-Regulation, Electrophoretic Mobility Shift Assay, Enzyme-Linked Immunosorbent Assay, HeLa Cells, Humans, Interleukin-8, Jurkat Cells, Lactones, NF-kappa B, Promoter Regions, Genetic, RNA, Messenger, Sesquiterpenes, Structure-Activity Relationship, Journal Article, Research Support, Non-U.S. Gov't",
author = "Lindenmeyer, {Maja T} and Andrea Hrenn and Claudia Kern and Victor Castro and Renato Murillo and Stefan M{\"u}ller and Stefan Laufer and J{\"u}rgen Schulte-M{\"o}nting and Bettina Siedle and Irmgard Merfort",
year = "2006",
month = apr,
day = "15",
doi = "10.1016/j.bmc.2005.11.027",
language = "English",
volume = "14",
pages = "2487--97",
journal = "BIOORGAN MED CHEM",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "8",

}

RIS

TY - JOUR

T1 - Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells

AU - Lindenmeyer, Maja T

AU - Hrenn, Andrea

AU - Kern, Claudia

AU - Castro, Victor

AU - Murillo, Renato

AU - Müller, Stefan

AU - Laufer, Stefan

AU - Schulte-Mönting, Jürgen

AU - Siedle, Bettina

AU - Merfort, Irmgard

PY - 2006/4/15

Y1 - 2006/4/15

N2 - Twenty-four structurally different SLs were studied for their inhibition on IL-8 production in HeLa229 cells and different IC50-values were obtained. QSAR analyses revealed that the alpha-methylene-gamma-lactone and the presence and reactivity of a second reaction center, expressed by LUMO2, are the most important descriptors for IL-8. Using two SLs as examples, we demonstrated that SLs prevent DNA binding of AP-1, which has binding sites in the IL-8 promoter together with NF-kappaB and C/EBP, and that this is probably due to directly targeting AP-1. p38 MAPK, which plays a role in AP-1 activation as well as in IL-8 regulation, was not influenced by SLs. These data show that NF-kappaB and AP-1, and consequently IL-8 may be interesting targets in antiinflammation research and that the small molecules of SLs may be powerful candidates with promising properties for therapeutic modulation of the inflammatory response.

AB - Twenty-four structurally different SLs were studied for their inhibition on IL-8 production in HeLa229 cells and different IC50-values were obtained. QSAR analyses revealed that the alpha-methylene-gamma-lactone and the presence and reactivity of a second reaction center, expressed by LUMO2, are the most important descriptors for IL-8. Using two SLs as examples, we demonstrated that SLs prevent DNA binding of AP-1, which has binding sites in the IL-8 promoter together with NF-kappaB and C/EBP, and that this is probably due to directly targeting AP-1. p38 MAPK, which plays a role in AP-1 activation as well as in IL-8 regulation, was not influenced by SLs. These data show that NF-kappaB and AP-1, and consequently IL-8 may be interesting targets in antiinflammation research and that the small molecules of SLs may be powerful candidates with promising properties for therapeutic modulation of the inflammatory response.

KW - Base Sequence

KW - CCAAT-Enhancer-Binding Proteins

KW - DNA Primers

KW - Down-Regulation

KW - Electrophoretic Mobility Shift Assay

KW - Enzyme-Linked Immunosorbent Assay

KW - HeLa Cells

KW - Humans

KW - Interleukin-8

KW - Jurkat Cells

KW - Lactones

KW - NF-kappa B

KW - Promoter Regions, Genetic

KW - RNA, Messenger

KW - Sesquiterpenes

KW - Structure-Activity Relationship

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.bmc.2005.11.027

DO - 10.1016/j.bmc.2005.11.027

M3 - SCORING: Journal article

C2 - 16326104

VL - 14

SP - 2487

EP - 2497

JO - BIOORGAN MED CHEM

JF - BIOORGAN MED CHEM

SN - 0968-0896

IS - 8

ER -