Serum levels of interleukin-6 and interleukin-10 in relation to depression scores in patients with cardiovascular risk factors.
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Serum levels of interleukin-6 and interleukin-10 in relation to depression scores in patients with cardiovascular risk factors. / Meyer, Thomas; Stanske, Beate; Kochen, Michael M; Cordes, Andreas; Yüksel, Iraz; Wachter, Rolf; Lüers, Claus; Scherer, Martin; Binder, Lutz; Pieske, Burkert; Herrmann-Lingen, Christoph.
in: BEHAV MED, Jahrgang 37, Nr. 3, 3, 2011, S. 105-112.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Serum levels of interleukin-6 and interleukin-10 in relation to depression scores in patients with cardiovascular risk factors.
AU - Meyer, Thomas
AU - Stanske, Beate
AU - Kochen, Michael M
AU - Cordes, Andreas
AU - Yüksel, Iraz
AU - Wachter, Rolf
AU - Lüers, Claus
AU - Scherer, Martin
AU - Binder, Lutz
AU - Pieske, Burkert
AU - Herrmann-Lingen, Christoph
PY - 2011
Y1 - 2011
N2 - It is currently unknown whether elevated cytokine levels in depression are confined to any specific subgroup of depressive patients. In this study, medical out-patients presenting with cardiovascular risk factors (N = 356) were assessed for both cognitive-affective and physical symptoms of depression using the Hospital Anxiety and Depression Scale (HADS) and the Maastricht questionnaire (MQ), respectively. In study participants assigned to the highest (?21) and lowest (?5) quartile for the MQ score, serum levels of cytokines were measured. We found highly significant associations between cognitive-affective symptoms of depression and elevated serum levels of interleukin-6 (IL-6; ? = .231; p = .002) and interleukin-10 (IL-10; ? = .370; p <.001), respectively. In multiple regression models elevated IL-10 serum concentration was independently related to cognitive-affective symptoms of depression (? = .165; p = .002). When all cytokines were included in one model, elevated IL-10 serum concentrations remained a significant predictor for depressive mood (? = .157; p = .009). In patients with cardiovascular risk factors and extreme scores for vital exhaustion, elevated serum IL-6 and even more IL-10 concentrations are linked to the presence of depressive mood. Future studies will have to test whether the so far unreported association of IL-10 with depressive mood represents a causal pathway involved in the pathogenesis or in the prognostic effect of depressive mood in cardiac patients.
AB - It is currently unknown whether elevated cytokine levels in depression are confined to any specific subgroup of depressive patients. In this study, medical out-patients presenting with cardiovascular risk factors (N = 356) were assessed for both cognitive-affective and physical symptoms of depression using the Hospital Anxiety and Depression Scale (HADS) and the Maastricht questionnaire (MQ), respectively. In study participants assigned to the highest (?21) and lowest (?5) quartile for the MQ score, serum levels of cytokines were measured. We found highly significant associations between cognitive-affective symptoms of depression and elevated serum levels of interleukin-6 (IL-6; ? = .231; p = .002) and interleukin-10 (IL-10; ? = .370; p <.001), respectively. In multiple regression models elevated IL-10 serum concentration was independently related to cognitive-affective symptoms of depression (? = .165; p = .002). When all cytokines were included in one model, elevated IL-10 serum concentrations remained a significant predictor for depressive mood (? = .157; p = .009). In patients with cardiovascular risk factors and extreme scores for vital exhaustion, elevated serum IL-6 and even more IL-10 concentrations are linked to the presence of depressive mood. Future studies will have to test whether the so far unreported association of IL-10 with depressive mood represents a causal pathway involved in the pathogenesis or in the prognostic effect of depressive mood in cardiac patients.
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Risk Factors
KW - Cohort Studies
KW - Biological Markers/blood
KW - Psychiatric Status Rating Scales/statistics & numerical data
KW - Cardiovascular Diseases/blood/metabolism
KW - Depression/blood/diagnosis/metabolism
KW - Interleukin-10/blood
KW - Interleukin-6/blood
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Risk Factors
KW - Cohort Studies
KW - Biological Markers/blood
KW - Psychiatric Status Rating Scales/statistics & numerical data
KW - Cardiovascular Diseases/blood/metabolism
KW - Depression/blood/diagnosis/metabolism
KW - Interleukin-10/blood
KW - Interleukin-6/blood
M3 - SCORING: Journal article
VL - 37
SP - 105
EP - 112
JO - BEHAV MED
JF - BEHAV MED
SN - 0896-4289
IS - 3
M1 - 3
ER -
