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Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation

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Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation. / Ayuketang, Francis Ayuk; Bussmann, Lara; Zabelina, Tatiana; Veit, Ronja; Alchalby, Haefaa; Wolschke, Christine; Lellek, Heinrich; Bacher, Ulrike; Zander, Axel R; Kröger, Nicolaus.

in: ANN HEMATOL, Jahrgang 93, Nr. 5, 01.05.2014, S. 855-61.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ayuketang, FA, Bussmann, L, Zabelina, T, Veit, R, Alchalby, H, Wolschke, C, Lellek, H, Bacher, U, Zander, AR & Kröger, N 2014, 'Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation', ANN HEMATOL, Jg. 93, Nr. 5, S. 855-61. https://doi.org/10.1007/s00277-013-1957-0

APA

Ayuketang, F. A., Bussmann, L., Zabelina, T., Veit, R., Alchalby, H., Wolschke, C., Lellek, H., Bacher, U., Zander, A. R., & Kröger, N. (2014). Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation. ANN HEMATOL, 93(5), 855-61. https://doi.org/10.1007/s00277-013-1957-0

Vancouver

Ayuketang FA, Bussmann L, Zabelina T, Veit R, Alchalby H, Wolschke C et al. Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation. ANN HEMATOL. 2014 Mai 1;93(5):855-61. https://doi.org/10.1007/s00277-013-1957-0

Bibtex

@article{cfe469db7579406bb0b511cb7c14467f,
title = "Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation",
abstract = "In a retrospective single-centre study, we analysed the prognostic impact of factors identifiable at initial diagnosis of acute GVHD (aGVHD). We retrospectively analysed 495 adult patients of whom 308 (62 %) developed acute GVHD (I-IV) and were included in further analysis. Gut aGVHD was diagnosed in 163/308 cases (53 %). Conditioning was myeloablative conditioning (MAC) in 123 (39.9 %) and reduced intensity (RIC) in 185 (60.1 %) patients. Median serum albumin level at diagnosis of aGVHD was 34 g/l, which was used as cut-off for low vs. normal albumin levels. In patients with gut aGVHD, low albumin level at the time of diagnosis of aGVHD was associated with poorer overall survival (OS) which was 52 vs. 67 % at 1 year and 40 vs. 61 % at 3 years, p = 0.015. In patients with only skin aGVHD, 1- and 3-year OS of patients with low vs. normal albumin levels were 72 vs. 72 % and 59 vs. 57 %, respectively, p = 0.69. In multivariate analysis of patients with gut aGVHD, low serum albumin level ≤34 g/l (relative risk (RR) 2.13, p = 0.003), gut aGVHD grades 3-4 (RR 2.70, p = 0.001), RIC (RR 1.84, p = 0.024), matched unrelated donor (RR 1.86, p = 0.18) and mismatched unrelated donor (RR 2.76, p = 0.03) retained negative impact on OS. Subgroup analysis revealed that impact of albumin was restricted to patients with gut aGVHD after RIC. Low serum albumin levels are associated with poorer OS in patients with gut but not skin aGVHD after RIC but not MAC allogeneic stem cell transplantation.",
keywords = "Acute Disease, Adolescent, Adult, Aged, Biological Markers, Female, Gastrointestinal Tract, Graft vs Host Disease, Hematologic Neoplasms, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Multivariate Analysis, Myeloablative Agonists, Prognosis, Retrospective Studies, Serum Albumin, Survival Analysis, Transplantation Conditioning, Transplantation, Homologous",
author = "Ayuketang, {Francis Ayuk} and Lara Bussmann and Tatiana Zabelina and Ronja Veit and Haefaa Alchalby and Christine Wolschke and Heinrich Lellek and Ulrike Bacher and Zander, {Axel R} and Nicolaus Kr{\"o}ger",
year = "2014",
month = may,
day = "1",
doi = "10.1007/s00277-013-1957-0",
language = "English",
volume = "93",
pages = "855--61",
journal = "ANN HEMATOL",
issn = "0939-5555",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation

AU - Ayuketang, Francis Ayuk

AU - Bussmann, Lara

AU - Zabelina, Tatiana

AU - Veit, Ronja

AU - Alchalby, Haefaa

AU - Wolschke, Christine

AU - Lellek, Heinrich

AU - Bacher, Ulrike

AU - Zander, Axel R

AU - Kröger, Nicolaus

PY - 2014/5/1

Y1 - 2014/5/1

N2 - In a retrospective single-centre study, we analysed the prognostic impact of factors identifiable at initial diagnosis of acute GVHD (aGVHD). We retrospectively analysed 495 adult patients of whom 308 (62 %) developed acute GVHD (I-IV) and were included in further analysis. Gut aGVHD was diagnosed in 163/308 cases (53 %). Conditioning was myeloablative conditioning (MAC) in 123 (39.9 %) and reduced intensity (RIC) in 185 (60.1 %) patients. Median serum albumin level at diagnosis of aGVHD was 34 g/l, which was used as cut-off for low vs. normal albumin levels. In patients with gut aGVHD, low albumin level at the time of diagnosis of aGVHD was associated with poorer overall survival (OS) which was 52 vs. 67 % at 1 year and 40 vs. 61 % at 3 years, p = 0.015. In patients with only skin aGVHD, 1- and 3-year OS of patients with low vs. normal albumin levels were 72 vs. 72 % and 59 vs. 57 %, respectively, p = 0.69. In multivariate analysis of patients with gut aGVHD, low serum albumin level ≤34 g/l (relative risk (RR) 2.13, p = 0.003), gut aGVHD grades 3-4 (RR 2.70, p = 0.001), RIC (RR 1.84, p = 0.024), matched unrelated donor (RR 1.86, p = 0.18) and mismatched unrelated donor (RR 2.76, p = 0.03) retained negative impact on OS. Subgroup analysis revealed that impact of albumin was restricted to patients with gut aGVHD after RIC. Low serum albumin levels are associated with poorer OS in patients with gut but not skin aGVHD after RIC but not MAC allogeneic stem cell transplantation.

AB - In a retrospective single-centre study, we analysed the prognostic impact of factors identifiable at initial diagnosis of acute GVHD (aGVHD). We retrospectively analysed 495 adult patients of whom 308 (62 %) developed acute GVHD (I-IV) and were included in further analysis. Gut aGVHD was diagnosed in 163/308 cases (53 %). Conditioning was myeloablative conditioning (MAC) in 123 (39.9 %) and reduced intensity (RIC) in 185 (60.1 %) patients. Median serum albumin level at diagnosis of aGVHD was 34 g/l, which was used as cut-off for low vs. normal albumin levels. In patients with gut aGVHD, low albumin level at the time of diagnosis of aGVHD was associated with poorer overall survival (OS) which was 52 vs. 67 % at 1 year and 40 vs. 61 % at 3 years, p = 0.015. In patients with only skin aGVHD, 1- and 3-year OS of patients with low vs. normal albumin levels were 72 vs. 72 % and 59 vs. 57 %, respectively, p = 0.69. In multivariate analysis of patients with gut aGVHD, low serum albumin level ≤34 g/l (relative risk (RR) 2.13, p = 0.003), gut aGVHD grades 3-4 (RR 2.70, p = 0.001), RIC (RR 1.84, p = 0.024), matched unrelated donor (RR 1.86, p = 0.18) and mismatched unrelated donor (RR 2.76, p = 0.03) retained negative impact on OS. Subgroup analysis revealed that impact of albumin was restricted to patients with gut aGVHD after RIC. Low serum albumin levels are associated with poorer OS in patients with gut but not skin aGVHD after RIC but not MAC allogeneic stem cell transplantation.

KW - Acute Disease

KW - Adolescent

KW - Adult

KW - Aged

KW - Biological Markers

KW - Female

KW - Gastrointestinal Tract

KW - Graft vs Host Disease

KW - Hematologic Neoplasms

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Myeloablative Agonists

KW - Prognosis

KW - Retrospective Studies

KW - Serum Albumin

KW - Survival Analysis

KW - Transplantation Conditioning

KW - Transplantation, Homologous

U2 - 10.1007/s00277-013-1957-0

DO - 10.1007/s00277-013-1957-0

M3 - SCORING: Journal article

C2 - 24248672

VL - 93

SP - 855

EP - 861

JO - ANN HEMATOL

JF - ANN HEMATOL

SN - 0939-5555

IS - 5

ER -