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Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation.

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Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation. / Heinz, Andreas; Smolka, Michael N; Braus, Dieter; Wrase, Jana; Beck, Anne; Flor, Herta; Mann, Karl; Schumann, Gunter; Büchel, Christian; Hariri, Ahmad R; Weinberger, Daniel R.

in: BIOL PSYCHIAT, Jahrgang 61, Nr. 8, 8, 2007, S. 1011-1014.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heinz, A, Smolka, MN, Braus, D, Wrase, J, Beck, A, Flor, H, Mann, K, Schumann, G, Büchel, C, Hariri, AR & Weinberger, DR 2007, 'Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation.', BIOL PSYCHIAT, Jg. 61, Nr. 8, 8, S. 1011-1014. <http://www.ncbi.nlm.nih.gov/pubmed/17157270?dopt=Citation>

APA

Heinz, A., Smolka, M. N., Braus, D., Wrase, J., Beck, A., Flor, H., Mann, K., Schumann, G., Büchel, C., Hariri, A. R., & Weinberger, D. R. (2007). Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation. BIOL PSYCHIAT, 61(8), 1011-1014. [8]. http://www.ncbi.nlm.nih.gov/pubmed/17157270?dopt=Citation

Vancouver

Heinz A, Smolka MN, Braus D, Wrase J, Beck A, Flor H et al. Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation. BIOL PSYCHIAT. 2007;61(8):1011-1014. 8.

Bibtex

@article{e44780c040304068820f21cbc49496ca,
title = "Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation.",
abstract = "BACKGROUND: A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) allele showed stronger amygdala activation than long (l) carriers. However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers. METHODS: Functional MRI was used to assess amygdala activation during the presentation of a fixation cross or affectively aversive or neutral visual stimuli in 29 healthy men. RESULTS: Amygdala activation was increased in s carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions. CONCLUSIONS: This finding suggests that s carriers show stronger amygdala reactivity to stimuli and contexts that are relatively uncertain, which we propose are stressful.",
author = "Andreas Heinz and Smolka, {Michael N} and Dieter Braus and Jana Wrase and Anne Beck and Herta Flor and Karl Mann and Gunter Schumann and Christian B{\"u}chel and Hariri, {Ahmad R} and Weinberger, {Daniel R}",
year = "2007",
language = "Deutsch",
volume = "61",
pages = "1011--1014",
journal = "BIOL PSYCHIAT",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "8",

}

RIS

TY - JOUR

T1 - Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation.

AU - Heinz, Andreas

AU - Smolka, Michael N

AU - Braus, Dieter

AU - Wrase, Jana

AU - Beck, Anne

AU - Flor, Herta

AU - Mann, Karl

AU - Schumann, Gunter

AU - Büchel, Christian

AU - Hariri, Ahmad R

AU - Weinberger, Daniel R

PY - 2007

Y1 - 2007

N2 - BACKGROUND: A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) allele showed stronger amygdala activation than long (l) carriers. However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers. METHODS: Functional MRI was used to assess amygdala activation during the presentation of a fixation cross or affectively aversive or neutral visual stimuli in 29 healthy men. RESULTS: Amygdala activation was increased in s carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions. CONCLUSIONS: This finding suggests that s carriers show stronger amygdala reactivity to stimuli and contexts that are relatively uncertain, which we propose are stressful.

AB - BACKGROUND: A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) allele showed stronger amygdala activation than long (l) carriers. However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers. METHODS: Functional MRI was used to assess amygdala activation during the presentation of a fixation cross or affectively aversive or neutral visual stimuli in 29 healthy men. RESULTS: Amygdala activation was increased in s carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions. CONCLUSIONS: This finding suggests that s carriers show stronger amygdala reactivity to stimuli and contexts that are relatively uncertain, which we propose are stressful.

M3 - SCORING: Zeitschriftenaufsatz

VL - 61

SP - 1011

EP - 1014

JO - BIOL PSYCHIAT

JF - BIOL PSYCHIAT

SN - 0006-3223

IS - 8

M1 - 8

ER -