Seroconversion of HBsAG coincides with hepatitis A super-infection: A case report
Beteiligte Einrichtungen
Abstract
BACKGROUND: Hepatitis B virus (HBV) is a hepatotropic virus that can cause acute and chronic liver damage. According to the world health organization 257 million people are infected with chronic HBV infection worldwide. Super-infection with other hepadnaviruses, including hepatitis A virus (HAV), hepatitis C virus, hepatitis D virus, and hepatitis E virus is associated with increased risk of acute liver failure in patients with chronic HBV.
CASE SUMMARY: Here, we report a case of a 47-year old male patient with HBV-related compensated Child A cirrhosis, who presented with general fatigue, malaise and laboratory signs of acute hepatitis. Although the patient was regularly seen at a specialized university liver unit, the HAV vaccination status was unclear. Acute HAV super-infection was diagnosed by positive serological and polymerase chain reaction analysis. Following acute HAV super-infection, spontaneous HBsAg elimination and development of an anti-HBs titer were observed.
CONCLUSION: This case illustrates the importance of carefully checking the vaccination status. In our patient, unspecific immunological responses to HAV led to functional cure of HBV.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 2307-8960 |
DOIs | |
Status | Veröffentlicht - 06.05.2020 |
Anmerkungen des Dekanats
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
PubMed | 32432143 |
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