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Serial NT-proBNP measurements for risk stratification of patients with decompensated heart failure

Standard

Serial NT-proBNP measurements for risk stratification of patients with decompensated heart failure. / Lüers, C; Schmidt, A; Wachter, R; Fritzsche, F; Sutcliffe, A; Kleta, S; Zapf, A; Hagenah, G; Binder, L; Maisch, B; Pieske, B.

in: HERZ, Jahrgang 35, Nr. 7, 10.2010, S. 488-495.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lüers, C, Schmidt, A, Wachter, R, Fritzsche, F, Sutcliffe, A, Kleta, S, Zapf, A, Hagenah, G, Binder, L, Maisch, B & Pieske, B 2010, 'Serial NT-proBNP measurements for risk stratification of patients with decompensated heart failure', HERZ, Jg. 35, Nr. 7, S. 488-495. https://doi.org/10.1007/s00059-010-3377-4

APA

Lüers, C., Schmidt, A., Wachter, R., Fritzsche, F., Sutcliffe, A., Kleta, S., Zapf, A., Hagenah, G., Binder, L., Maisch, B., & Pieske, B. (2010). Serial NT-proBNP measurements for risk stratification of patients with decompensated heart failure. HERZ, 35(7), 488-495. https://doi.org/10.1007/s00059-010-3377-4

Vancouver

Lüers C, Schmidt A, Wachter R, Fritzsche F, Sutcliffe A, Kleta S et al. Serial NT-proBNP measurements for risk stratification of patients with decompensated heart failure. HERZ. 2010 Okt;35(7):488-495. https://doi.org/10.1007/s00059-010-3377-4

Bibtex

@article{2431fa94b9034a1fb24c2452b133c111,
title = "Serial NT-proBNP measurements for risk stratification of patients with decompensated heart failure",
abstract = "PURPOSE: NT-proBNP is an important prognostic predictor in patients with heart failure. However, it is unknown whether a change of NT-proBNP plasma levels in the early phase of decompensation might be of additional prognostic value in patients with acute decompensation of heart failure.METHODS AND RESULTS: NT-proBNP plasma levels of 116 patients with decompensated heart failure from ischemic/non-ischemic origin were measured at baseline and at 12, 24 and 48 h after hospital admission. Baseline levels and changes of plasma levels within the first 48 h were correlated with 30-day mortality. In all patients, NT-proBNP 12 h after admission was highest and superior with respect to the prediction of 30-day mortality compared to plasma levels on admission. In total, 38 patients died within the first 30 days. In these patients absolute NT-proBNP plasma levels were significantly higher and the increase within 12 h after admission was more pronounced compared to survivors (p<0.001). NT-proBNP at 12 h after admission also had the highest predictive value for the 30-day mortality rate in patients with acute myocardial infarction. The increase of NT-proBNP plasma levels within 12 h after admission had the highest predictive value in patients suffering from decompensated heart failure.CONCLUSIONS: NT-proBNP is a powerful marker of 30-day mortality in patients with decompensated heart failure of ischemic and non-ischemic origin. Compared with single baseline measurements, serial measurements of NT-proBNP plasma levels within 12 h after hospital admission may be used to increase the predictive value of NT-proBNP with regard to the early identification of patients who are at high risk of mortality.",
keywords = "Aged, Biomarkers, Female, Germany, Heart Failure, Humans, Male, Natriuretic Peptide, Brain, Peptide Fragments, Prevalence, Reproducibility of Results, Risk Assessment, Risk Factors, Sensitivity and Specificity, Survival Analysis, Survival Rate, Journal Article",
author = "C L{\"u}ers and A Schmidt and R Wachter and F Fritzsche and A Sutcliffe and S Kleta and A Zapf and G Hagenah and L Binder and B Maisch and B Pieske",
year = "2010",
month = oct,
doi = "10.1007/s00059-010-3377-4",
language = "English",
volume = "35",
pages = "488--495",
journal = "HERZ",
issn = "0340-9937",
publisher = "Urban und Vogel",
number = "7",

}

RIS

TY - JOUR

T1 - Serial NT-proBNP measurements for risk stratification of patients with decompensated heart failure

AU - Lüers, C

AU - Schmidt, A

AU - Wachter, R

AU - Fritzsche, F

AU - Sutcliffe, A

AU - Kleta, S

AU - Zapf, A

AU - Hagenah, G

AU - Binder, L

AU - Maisch, B

AU - Pieske, B

PY - 2010/10

Y1 - 2010/10

N2 - PURPOSE: NT-proBNP is an important prognostic predictor in patients with heart failure. However, it is unknown whether a change of NT-proBNP plasma levels in the early phase of decompensation might be of additional prognostic value in patients with acute decompensation of heart failure.METHODS AND RESULTS: NT-proBNP plasma levels of 116 patients with decompensated heart failure from ischemic/non-ischemic origin were measured at baseline and at 12, 24 and 48 h after hospital admission. Baseline levels and changes of plasma levels within the first 48 h were correlated with 30-day mortality. In all patients, NT-proBNP 12 h after admission was highest and superior with respect to the prediction of 30-day mortality compared to plasma levels on admission. In total, 38 patients died within the first 30 days. In these patients absolute NT-proBNP plasma levels were significantly higher and the increase within 12 h after admission was more pronounced compared to survivors (p<0.001). NT-proBNP at 12 h after admission also had the highest predictive value for the 30-day mortality rate in patients with acute myocardial infarction. The increase of NT-proBNP plasma levels within 12 h after admission had the highest predictive value in patients suffering from decompensated heart failure.CONCLUSIONS: NT-proBNP is a powerful marker of 30-day mortality in patients with decompensated heart failure of ischemic and non-ischemic origin. Compared with single baseline measurements, serial measurements of NT-proBNP plasma levels within 12 h after hospital admission may be used to increase the predictive value of NT-proBNP with regard to the early identification of patients who are at high risk of mortality.

AB - PURPOSE: NT-proBNP is an important prognostic predictor in patients with heart failure. However, it is unknown whether a change of NT-proBNP plasma levels in the early phase of decompensation might be of additional prognostic value in patients with acute decompensation of heart failure.METHODS AND RESULTS: NT-proBNP plasma levels of 116 patients with decompensated heart failure from ischemic/non-ischemic origin were measured at baseline and at 12, 24 and 48 h after hospital admission. Baseline levels and changes of plasma levels within the first 48 h were correlated with 30-day mortality. In all patients, NT-proBNP 12 h after admission was highest and superior with respect to the prediction of 30-day mortality compared to plasma levels on admission. In total, 38 patients died within the first 30 days. In these patients absolute NT-proBNP plasma levels were significantly higher and the increase within 12 h after admission was more pronounced compared to survivors (p<0.001). NT-proBNP at 12 h after admission also had the highest predictive value for the 30-day mortality rate in patients with acute myocardial infarction. The increase of NT-proBNP plasma levels within 12 h after admission had the highest predictive value in patients suffering from decompensated heart failure.CONCLUSIONS: NT-proBNP is a powerful marker of 30-day mortality in patients with decompensated heart failure of ischemic and non-ischemic origin. Compared with single baseline measurements, serial measurements of NT-proBNP plasma levels within 12 h after hospital admission may be used to increase the predictive value of NT-proBNP with regard to the early identification of patients who are at high risk of mortality.

KW - Aged

KW - Biomarkers

KW - Female

KW - Germany

KW - Heart Failure

KW - Humans

KW - Male

KW - Natriuretic Peptide, Brain

KW - Peptide Fragments

KW - Prevalence

KW - Reproducibility of Results

KW - Risk Assessment

KW - Risk Factors

KW - Sensitivity and Specificity

KW - Survival Analysis

KW - Survival Rate

KW - Journal Article

U2 - 10.1007/s00059-010-3377-4

DO - 10.1007/s00059-010-3377-4

M3 - SCORING: Journal article

C2 - 20927502

VL - 35

SP - 488

EP - 495

JO - HERZ

JF - HERZ

SN - 0340-9937

IS - 7

ER -