Sequential MR Assessment of the Susceptibility Vessel Sign and Arterial Occlusion in Acute Stroke
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Sequential MR Assessment of the Susceptibility Vessel Sign and Arterial Occlusion in Acute Stroke. / Ritzenthaler, Thomas; Lacalm, Audrey; Cho, Tae-Hee; Maucort-Boulch, Delphine; Klaerke Mikkelsen, Irene; Ribe, Lars; Østergaard, Leif; Hjort, Niels; Fiehler, Jens; Pedraza, Salvador; Louis Tisserand, Guy; Baron, Jean-Claude; Berthezene, Yves; Nighoghossian, Norbert.
in: J NEUROIMAGING, Jahrgang 26, Nr. 3, 01.05.2016, S. 355-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Sequential MR Assessment of the Susceptibility Vessel Sign and Arterial Occlusion in Acute Stroke
AU - Ritzenthaler, Thomas
AU - Lacalm, Audrey
AU - Cho, Tae-Hee
AU - Maucort-Boulch, Delphine
AU - Klaerke Mikkelsen, Irene
AU - Ribe, Lars
AU - Østergaard, Leif
AU - Hjort, Niels
AU - Fiehler, Jens
AU - Pedraza, Salvador
AU - Louis Tisserand, Guy
AU - Baron, Jean-Claude
AU - Berthezene, Yves
AU - Nighoghossian, Norbert
N1 - Copyright © 2015 by the American Society of Neuroimaging.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - PURPOSE: Susceptibility vessel sign (SVS) may likely influence recanalization after thrombolysis. We assessed, through the European sequential MRI database "I-KNOW," the relationship between the presence of SVS on T2-weighted gradient echo imaging, its angiographic counterpart on magnetic resonance angiography and its subsequent impact on recanalization after thrombolysis.MATERIALS AND METHODS: Initial clinical and MRI characteristics and early follow up were analyzed in acute ischemic stroke patients treated with rt-Pa within 4.5 hours. Patients underwent multimodal MRI at admission. Sequential imaging performed 3 hours, 2 days and 1 month later allowed the analysis of SVS changes and recanalization.RESULTS: Fifty patients were included in the study. SVS was observed in 54% of cases at admission. SVS was still present in 46% patients at 3 hours, 16% at 2 days, and 0% at 1 month. It was an independent predictor of no recanalization after thrombolysis (P = .04). After 3 hours, SVS disappeared in only 4 cases, and was not linked with recanalization on MRA. Conversely, when SVS persisted, a partial or complete recanalization was observed in 9 and 6 cases, respectively.CONCLUSIONS: SVS is a predictor of lower recanalization rate. Its disappearance is not necessarily correlated with recanalization.
AB - PURPOSE: Susceptibility vessel sign (SVS) may likely influence recanalization after thrombolysis. We assessed, through the European sequential MRI database "I-KNOW," the relationship between the presence of SVS on T2-weighted gradient echo imaging, its angiographic counterpart on magnetic resonance angiography and its subsequent impact on recanalization after thrombolysis.MATERIALS AND METHODS: Initial clinical and MRI characteristics and early follow up were analyzed in acute ischemic stroke patients treated with rt-Pa within 4.5 hours. Patients underwent multimodal MRI at admission. Sequential imaging performed 3 hours, 2 days and 1 month later allowed the analysis of SVS changes and recanalization.RESULTS: Fifty patients were included in the study. SVS was observed in 54% of cases at admission. SVS was still present in 46% patients at 3 hours, 16% at 2 days, and 0% at 1 month. It was an independent predictor of no recanalization after thrombolysis (P = .04). After 3 hours, SVS disappeared in only 4 cases, and was not linked with recanalization on MRA. Conversely, when SVS persisted, a partial or complete recanalization was observed in 9 and 6 cases, respectively.CONCLUSIONS: SVS is a predictor of lower recanalization rate. Its disappearance is not necessarily correlated with recanalization.
U2 - 10.1111/jon.12312
DO - 10.1111/jon.12312
M3 - SCORING: Journal article
C2 - 26552863
VL - 26
SP - 355
EP - 359
JO - J NEUROIMAGING
JF - J NEUROIMAGING
SN - 1051-2284
IS - 3
ER -
