[Sepsis-like disease in an immunocompromised patient with a travel history to Mallorca]

G C Hagenah; T Wündisch; E Eckstein; S Zimmermann; Frederik Holst; W Grimm; A Neubauer; M Lohoff

[Sepsis-like disease in an immunocompromised patient with a travel history to Mallorca]

Standard

[Sepsis-like disease in an immunocompromised patient with a travel history to Mallorca]. / Hagenah, G C; Wündisch, T; Eckstein, E; Zimmermann, S; Holst, Frederik; Grimm, W; Neubauer, A; Lohoff, M.

in: INTERNIST, Jahrgang 48, Nr. 7, 7, 2007, S. 727-730.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hagenah, GC, Wündisch, T, Eckstein, E, Zimmermann, S, Holst, F, Grimm, W, Neubauer, A & Lohoff, M 2007, '[Sepsis-like disease in an immunocompromised patient with a travel history to Mallorca]', INTERNIST, Jg. 48, Nr. 7, 7, S. 727-730. <http://www.ncbi.nlm.nih.gov/pubmed/17541532?dopt=Citation>

APA

Hagenah, G. C., Wündisch, T., Eckstein, E., Zimmermann, S., Holst, F., Grimm, W., Neubauer, A., & Lohoff, M. (2007). [Sepsis-like disease in an immunocompromised patient with a travel history to Mallorca]. INTERNIST, 48(7), 727-730. [7]. http://www.ncbi.nlm.nih.gov/pubmed/17541532?dopt=Citation

Vancouver

Hagenah GC, Wündisch T, Eckstein E, Zimmermann S, Holst F, Grimm W et al. [Sepsis-like disease in an immunocompromised patient with a travel history to Mallorca]. INTERNIST. 2007;48(7):727-730. 7.

Bibtex

@article{06c4c460b4ec45dca5e582af3c76b8d6,

title = "[Sepsis-like disease in an immunocompromised patient with a travel history to Mallorca]",

abstract = "In immunosuppressed patients, a high rate of complications due to opportunistic infection is known. We report the case of a 36 year old patient with ulcerative colitis and a septic complication with ongoing pancytopenia. Due to colonic perforation, colectomy had to be performed. Despite this intervention, the septic constellation persisted. The pancytopenia in peripheral blood counts also persisted with the necessity of repetitive transfusions. A bone marrow biopsy showed an infiltration with Leishmania bodies in macrophages. Tissue culture allowed for typing of the parasites as belonging to the L. donovani/infantum complex, DNA sequencing confirmed infection with L. infantum. This infection must have been contracted during a vacation on Mallorca about 1.5 years earlier. Administration of liposomal amphotericin B cured the patient. Surprisingly, histological examination of the resected colon reveiled the presence of an immunoblastic B-cell lymphoma. In this case, immunosuppression was a prerequisite for the manifestation of leishmaniosis.",

keywords = "Adult, Animals, Azathioprine adverse effects, Biopsy, Bone Marrow pathology, Colectomy, Colitis, Ulcerative drug therapy, Colon pathology, Colonic Neoplasms diagnosis, Comorbidity, Desoxycorticosterone adverse effects, Diagnosis, Differential, Germany, Humans, Immunologic Deficiency Syndromes chemically induced, Immunosuppressive Agents adverse effects, Leishmania infantum, Leishmaniasis, Visceral diagnosis, Lymphoma, Large-Cell, Immunoblastic diagnosis, Male, Pancytopenia etiology, Sepsis etiology, Spain, Travel, Adult, Animals, Azathioprine adverse effects, Biopsy, Bone Marrow pathology, Colectomy, Colitis, Ulcerative drug therapy, Colon pathology, Colonic Neoplasms diagnosis, Comorbidity, Desoxycorticosterone adverse effects, Diagnosis, Differential, Germany, Humans, Immunologic Deficiency Syndromes chemically induced, Immunosuppressive Agents adverse effects, Leishmania infantum, Leishmaniasis, Visceral diagnosis, Lymphoma, Large-Cell, Immunoblastic diagnosis, Male, Pancytopenia etiology, Sepsis etiology, Spain, Travel",

author = "Hagenah, {G C} and T W{\"u}ndisch and E Eckstein and S Zimmermann and Frederik Holst and W Grimm and A Neubauer and M Lohoff",

year = "2007",

language = "Deutsch",

volume = "48",

pages = "727--730",

journal = "INTERNIST",

issn = "0020-9554",

publisher = "Springer",

number = "7",

}

RIS

TY - JOUR

T1 - [Sepsis-like disease in an immunocompromised patient with a travel history to Mallorca]

AU - Hagenah, G C

AU - Wündisch, T

AU - Eckstein, E

AU - Zimmermann, S

AU - Holst, Frederik

AU - Grimm, W

AU - Neubauer, A

AU - Lohoff, M

PY - 2007

Y1 - 2007

N2 - In immunosuppressed patients, a high rate of complications due to opportunistic infection is known. We report the case of a 36 year old patient with ulcerative colitis and a septic complication with ongoing pancytopenia. Due to colonic perforation, colectomy had to be performed. Despite this intervention, the septic constellation persisted. The pancytopenia in peripheral blood counts also persisted with the necessity of repetitive transfusions. A bone marrow biopsy showed an infiltration with Leishmania bodies in macrophages. Tissue culture allowed for typing of the parasites as belonging to the L. donovani/infantum complex, DNA sequencing confirmed infection with L. infantum. This infection must have been contracted during a vacation on Mallorca about 1.5 years earlier. Administration of liposomal amphotericin B cured the patient. Surprisingly, histological examination of the resected colon reveiled the presence of an immunoblastic B-cell lymphoma. In this case, immunosuppression was a prerequisite for the manifestation of leishmaniosis.

AB - In immunosuppressed patients, a high rate of complications due to opportunistic infection is known. We report the case of a 36 year old patient with ulcerative colitis and a septic complication with ongoing pancytopenia. Due to colonic perforation, colectomy had to be performed. Despite this intervention, the septic constellation persisted. The pancytopenia in peripheral blood counts also persisted with the necessity of repetitive transfusions. A bone marrow biopsy showed an infiltration with Leishmania bodies in macrophages. Tissue culture allowed for typing of the parasites as belonging to the L. donovani/infantum complex, DNA sequencing confirmed infection with L. infantum. This infection must have been contracted during a vacation on Mallorca about 1.5 years earlier. Administration of liposomal amphotericin B cured the patient. Surprisingly, histological examination of the resected colon reveiled the presence of an immunoblastic B-cell lymphoma. In this case, immunosuppression was a prerequisite for the manifestation of leishmaniosis.

KW - Adult

KW - Animals

KW - Azathioprine adverse effects

KW - Biopsy

KW - Bone Marrow pathology

KW - Colectomy

KW - Colitis, Ulcerative drug therapy

KW - Colon pathology

KW - Colonic Neoplasms diagnosis

KW - Comorbidity

KW - Desoxycorticosterone adverse effects

KW - Diagnosis, Differential

KW - Germany

KW - Humans

KW - Immunologic Deficiency Syndromes chemically induced

KW - Immunosuppressive Agents adverse effects

KW - Leishmania infantum

KW - Leishmaniasis, Visceral diagnosis

KW - Lymphoma, Large-Cell, Immunoblastic diagnosis

KW - Male

KW - Pancytopenia etiology

KW - Sepsis etiology

KW - Spain

KW - Travel