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Sensitivity enhancement in Magnetic Particle Imaging by Background Subtraction

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Sensitivity enhancement in Magnetic Particle Imaging by Background Subtraction. / Them, Kolja; Kaul, Michael; Jung, Caroline; Hofmann, Martin; Mummert, Tobias; Werner, Franziska; Knopp, Tobias.

in: IEEE T MED IMAGING, Jahrgang 35, Nr. 3, 03.2016, S. 893-900.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Them, K, Kaul, M, Jung, C, Hofmann, M, Mummert, T, Werner, F & Knopp, T 2016, 'Sensitivity enhancement in Magnetic Particle Imaging by Background Subtraction', IEEE T MED IMAGING, Jg. 35, Nr. 3, S. 893-900. https://doi.org/10.1109/TMI.2015.2501462

APA

Them, K., Kaul, M., Jung, C., Hofmann, M., Mummert, T., Werner, F., & Knopp, T. (2016). Sensitivity enhancement in Magnetic Particle Imaging by Background Subtraction. IEEE T MED IMAGING, 35(3), 893-900. https://doi.org/10.1109/TMI.2015.2501462

Vancouver

Them K, Kaul M, Jung C, Hofmann M, Mummert T, Werner F et al. Sensitivity enhancement in Magnetic Particle Imaging by Background Subtraction. IEEE T MED IMAGING. 2016 Mär;35(3):893-900. https://doi.org/10.1109/TMI.2015.2501462

Bibtex

@article{d1648c6ef21146b682e9fc914971556b,
title = "Sensitivity enhancement in Magnetic Particle Imaging by Background Subtraction",
abstract = "Biomedical applications such as cell tracking and angiography require the detection of low concentrations of superparamagnetic iron oxide nanoparticles (SPIOs) for imaging purposes. Magnetic particle imaging (MPI) is a new technology which enables the quantitative and time-resolved localization of SPIO distributions. However, the minimum concentration at which the SPIOs can be reconstructed with a suitable quality still remains to be investigated. In this work we examine the background signals in raw data that were measured without any SPIOs in the scanner tube. We show that a background subtraction in combination with a frequency cutoff for the dynamic part of the background signal lowers the detection limit for SPIOs in MPI up to a factor of ten. In-vivo mouse experiments show that for early time points from when the tracer enters the vena cava a reconstructed image of sufficient quality can only be obtained when a background subtraction is performed.",
author = "Kolja Them and Michael Kaul and Caroline Jung and Martin Hofmann and Tobias Mummert and Franziska Werner and Tobias Knopp",
year = "2016",
month = mar,
doi = "10.1109/TMI.2015.2501462",
language = "English",
volume = "35",
pages = "893--900",
journal = "IEEE T MED IMAGING",
issn = "0278-0062",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Sensitivity enhancement in Magnetic Particle Imaging by Background Subtraction

AU - Them, Kolja

AU - Kaul, Michael

AU - Jung, Caroline

AU - Hofmann, Martin

AU - Mummert, Tobias

AU - Werner, Franziska

AU - Knopp, Tobias

PY - 2016/3

Y1 - 2016/3

N2 - Biomedical applications such as cell tracking and angiography require the detection of low concentrations of superparamagnetic iron oxide nanoparticles (SPIOs) for imaging purposes. Magnetic particle imaging (MPI) is a new technology which enables the quantitative and time-resolved localization of SPIO distributions. However, the minimum concentration at which the SPIOs can be reconstructed with a suitable quality still remains to be investigated. In this work we examine the background signals in raw data that were measured without any SPIOs in the scanner tube. We show that a background subtraction in combination with a frequency cutoff for the dynamic part of the background signal lowers the detection limit for SPIOs in MPI up to a factor of ten. In-vivo mouse experiments show that for early time points from when the tracer enters the vena cava a reconstructed image of sufficient quality can only be obtained when a background subtraction is performed.

AB - Biomedical applications such as cell tracking and angiography require the detection of low concentrations of superparamagnetic iron oxide nanoparticles (SPIOs) for imaging purposes. Magnetic particle imaging (MPI) is a new technology which enables the quantitative and time-resolved localization of SPIO distributions. However, the minimum concentration at which the SPIOs can be reconstructed with a suitable quality still remains to be investigated. In this work we examine the background signals in raw data that were measured without any SPIOs in the scanner tube. We show that a background subtraction in combination with a frequency cutoff for the dynamic part of the background signal lowers the detection limit for SPIOs in MPI up to a factor of ten. In-vivo mouse experiments show that for early time points from when the tracer enters the vena cava a reconstructed image of sufficient quality can only be obtained when a background subtraction is performed.

U2 - 10.1109/TMI.2015.2501462

DO - 10.1109/TMI.2015.2501462

M3 - SCORING: Journal article

C2 - 26599700

VL - 35

SP - 893

EP - 900

JO - IEEE T MED IMAGING

JF - IEEE T MED IMAGING

SN - 0278-0062

IS - 3

ER -