Semiconductor technology in protein kinase research and drug discovery: sensing a revolution

Nikhil Bhalla; Mirella Di Lorenzo; Pedro Estrela; Giordano Pula

doi:10.1016/j.drudis.2016.10.006

Semiconductor technology in protein kinase research and drug discovery

Standard

Semiconductor technology in protein kinase research and drug discovery : sensing a revolution. / Bhalla, Nikhil; Di Lorenzo, Mirella; Estrela, Pedro; Pula, Giordano.

in: DRUG DISCOV TODAY, Jahrgang 22, Nr. 2, 02.2017, S. 204-209.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bhalla, N, Di Lorenzo, M, Estrela, P & Pula, G 2017, 'Semiconductor technology in protein kinase research and drug discovery: sensing a revolution', DRUG DISCOV TODAY, Jg. 22, Nr. 2, S. 204-209. https://doi.org/10.1016/j.drudis.2016.10.006

APA

Bhalla, N., Di Lorenzo, M., Estrela, P., & Pula, G. (2017). Semiconductor technology in protein kinase research and drug discovery: sensing a revolution. DRUG DISCOV TODAY, 22(2), 204-209. https://doi.org/10.1016/j.drudis.2016.10.006

Vancouver

Bhalla N, Di Lorenzo M, Estrela P, Pula G. Semiconductor technology in protein kinase research and drug discovery: sensing a revolution. DRUG DISCOV TODAY. 2017 Feb;22(2):204-209. https://doi.org/10.1016/j.drudis.2016.10.006

Bibtex

@article{13e9f31d579a40a295147b6422be5e21,

title = "Semiconductor technology in protein kinase research and drug discovery: sensing a revolution",

abstract = "Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal cell and tissue physiology. Therefore, protein kinase inhibitors are investigated as potential treatments for several diseases, including dementia, diabetes, cancer and autoimmune and cardiovascular disease. Modern semiconductor technology has recently been applied to accelerate the discovery of novel protein kinase inhibitors that could become the standard-of-care drugs of tomorrow. Here, we describe current techniques and novel applications of semiconductor technologies in protein kinase inhibitor drug discovery.",

keywords = "Drug Discovery, Phosphorylation, Protein Kinase Inhibitors, Protein Kinases/metabolism, Semiconductors, Surface Plasmon Resonance",

author = "Nikhil Bhalla and {Di Lorenzo}, Mirella and Pedro Estrela and Giordano Pula",

year = "2017",

month = feb,

doi = "10.1016/j.drudis.2016.10.006",

language = "English",

volume = "22",

pages = "204--209",

journal = "DRUG DISCOV TODAY",

issn = "1359-6446",

publisher = "Elsevier Limited",

number = "2",

}

RIS

TY - JOUR

T1 - Semiconductor technology in protein kinase research and drug discovery

T2 - sensing a revolution

AU - Bhalla, Nikhil

AU - Di Lorenzo, Mirella

AU - Estrela, Pedro

AU - Pula, Giordano

PY - 2017/2

Y1 - 2017/2

N2 - Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal cell and tissue physiology. Therefore, protein kinase inhibitors are investigated as potential treatments for several diseases, including dementia, diabetes, cancer and autoimmune and cardiovascular disease. Modern semiconductor technology has recently been applied to accelerate the discovery of novel protein kinase inhibitors that could become the standard-of-care drugs of tomorrow. Here, we describe current techniques and novel applications of semiconductor technologies in protein kinase inhibitor drug discovery.

AB - Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal cell and tissue physiology. Therefore, protein kinase inhibitors are investigated as potential treatments for several diseases, including dementia, diabetes, cancer and autoimmune and cardiovascular disease. Modern semiconductor technology has recently been applied to accelerate the discovery of novel protein kinase inhibitors that could become the standard-of-care drugs of tomorrow. Here, we describe current techniques and novel applications of semiconductor technologies in protein kinase inhibitor drug discovery.

KW - Drug Discovery

KW - Phosphorylation

KW - Protein Kinase Inhibitors

KW - Protein Kinases/metabolism

KW - Semiconductors

KW - Surface Plasmon Resonance

U2 - 10.1016/j.drudis.2016.10.006

DO - 10.1016/j.drudis.2016.10.006

M3 - SCORING: Journal article

C2 - 27780788

VL - 22

SP - 204

EP - 209

JO - DRUG DISCOV TODAY

JF - DRUG DISCOV TODAY

SN - 1359-6446

IS - 2

ER -